Death has occurred within 17 minutes of ingestion.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order tetraodontiformes, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction. Tetrodotoxin is being investigated by Wex Pharmaceuticals for the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Hydrocodone | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Magnesium sulfate | The therapeutic efficacy of Tetrodotoxin can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Tetrodotoxin may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Mirtazapine | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Orphenadrine | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Pramipexole | Tetrodotoxin may increase the sedative activities of Pramipexole. |
| Ropinirole | Tetrodotoxin may increase the sedative activities of Ropinirole. |
| Rotigotine | Tetrodotoxin may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Tetrodotoxin. |
| Sodium oxybate | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Thalidomide | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Hyaluronidase (ovine) | Hyaluronidase (ovine) can cause an increase in the absorption of Tetrodotoxin resulting in an increased serum concentration and potentially a worsening of adverse effects. |
| Hyaluronidase (human recombinant) | Hyaluronidase (human recombinant) can cause an increase in the absorption of Tetrodotoxin resulting in an increased serum concentration and potentially a worsening of adverse effects. |
| Hyaluronidase | Hyaluronidase can cause an increase in the absorption of Tetrodotoxin resulting in an increased serum concentration and potentially a worsening of adverse effects. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Tetrodotoxin. |
| Ethanol | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Fluvoxamine. |
| Citalopram | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Citalopram. |
| Duloxetine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Duloxetine. |
| Trazodone | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Paroxetine. |
| Sertraline | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Sibutramine. |
| Nefazodone | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Nefazodone. |
| Escitalopram | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Alaproclate. |
| Technetium Tc-99m tilmanocept | Tetrodotoxin may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent. |
| Amitriptyline | The risk or severity of CNS depression can be increased when Amitriptyline is combined with Tetrodotoxin. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Tetrodotoxin. |
| Imipramine | The risk or severity of CNS depression can be increased when Imipramine is combined with Tetrodotoxin. |
| Nortriptyline | The risk or severity of CNS depression can be increased when Nortriptyline is combined with Tetrodotoxin. |
| Amoxapine | The risk or severity of CNS depression can be increased when Amoxapine is combined with Tetrodotoxin. |
| Propiomazine | The risk or severity of CNS depression can be increased when Propiomazine is combined with Tetrodotoxin. |
| Cocaine | The risk or severity of methemoglobinemia can be increased when Cocaine is combined with Tetrodotoxin. |
| Quinidine | The risk or severity of methemoglobinemia can be increased when Quinidine is combined with Tetrodotoxin. |
| Maprotiline | The risk or severity of CNS depression can be increased when Maprotiline is combined with Tetrodotoxin. |
| Doxepin | The risk or severity of CNS depression can be increased when Doxepin is combined with Tetrodotoxin. |
| Desipramine | The risk or severity of CNS depression can be increased when Desipramine is combined with Tetrodotoxin. |
| Pizotifen | The risk or severity of CNS depression can be increased when Tetrodotoxin is combined with Pizotifen. |
| Dosulepin | The risk or severity of CNS depression can be increased when Tetrodotoxin is combined with Dosulepin. |
| Zopiclone | The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Zopiclone. |
| Botulinum toxin type B | The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Tetrodotoxin. |
| Botulinum toxin type A | The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Tetrodotoxin. |
| Tryptophan | The risk or severity of CNS depression can be increased when Tryptophan is combined with Tetrodotoxin. |
| Baclofen | Baclofen may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin. |
| Lorazepam | The risk or severity of methemoglobinemia can be increased when Lorazepam is combined with Tetrodotoxin. |
| Ethchlorvynol | The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Tetrodotoxin. |
| Succinylcholine | The risk or severity of CNS depression can be increased when Succinylcholine is combined with Tetrodotoxin. |
| Reserpine | The risk or severity of CNS depression can be increased when Reserpine is combined with Tetrodotoxin. |
| Eletriptan | The risk or severity of CNS depression can be increased when Eletriptan is combined with Tetrodotoxin. |
| Enflurane | The risk or severity of CNS depression can be increased when Enflurane is combined with Tetrodotoxin. |
| Temazepam | The risk or severity of CNS depression can be increased when Temazepam is combined with Tetrodotoxin. |
| Reboxetine | The risk or severity of CNS depression can be increased when Reboxetine is combined with Tetrodotoxin. |
| Butabarbital | The risk or severity of CNS depression can be increased when Butabarbital is combined with Tetrodotoxin. |
| Butalbital | The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Tetrodotoxin. |
| Methysergide | The risk or severity of CNS depression can be increased when Methysergide is combined with Tetrodotoxin. |
| Cabergoline | The risk or severity of methemoglobinemia can be increased when Cabergoline is combined with Tetrodotoxin. |
| Phenytoin | The risk or severity of methemoglobinemia can be increased when Phenytoin is combined with Tetrodotoxin. |
| Topiramate | The risk or severity of methemoglobinemia can be increased when Topiramate is combined with Tetrodotoxin. |
| Clemastine | The risk or severity of CNS depression can be increased when Clemastine is combined with Tetrodotoxin. |
| Venlafaxine | The risk or severity of CNS depression can be increased when Venlafaxine is combined with Tetrodotoxin. |
| Etomidate | The risk or severity of CNS depression can be increased when Etomidate is combined with Tetrodotoxin. |
| Morphine | The risk or severity of CNS depression can be increased when Morphine is combined with Tetrodotoxin. |
| Talbutal | The risk or severity of CNS depression can be increased when Talbutal is combined with Tetrodotoxin. |
| Pentobarbital | The risk or severity of methemoglobinemia can be increased when Pentobarbital is combined with Tetrodotoxin. |
| Valproic acid | The risk or severity of methemoglobinemia can be increased when Valproic acid is combined with Tetrodotoxin. |
| Zolmitriptan | The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Tetrodotoxin. |
| Codeine | The risk or severity of CNS depression can be increased when Codeine is combined with Tetrodotoxin. |
| Dihydroergotamine | The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Tetrodotoxin. |
| Tolcapone | The risk or severity of CNS depression can be increased when Tolcapone is combined with Tetrodotoxin. |
| Hydromorphone | The risk or severity of CNS depression can be increased when Hydromorphone is combined with Tetrodotoxin. |
| Olanzapine | The risk or severity of CNS depression can be increased when Olanzapine is combined with Tetrodotoxin. |
| Cetirizine | The risk or severity of CNS depression can be increased when Cetirizine is combined with Tetrodotoxin. |
| Protriptyline | The risk or severity of CNS depression can be increased when Protriptyline is combined with Tetrodotoxin. |
| Trimethadione | The risk or severity of methemoglobinemia can be increased when Trimethadione is combined with Tetrodotoxin. |
| Clobazam | The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Tetrodotoxin. |
| Chlorzoxazone | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Tetrodotoxin. |
| Clozapine | The risk or severity of CNS depression can be increased when Clozapine is combined with Tetrodotoxin. |