Beraprost

DB05229

small molecule investigational

Deskripsi

Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.

Struktur Molekul 2D

Berat 398.499
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 35–40 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Oral bioavailability is 50–70%.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Interaksi Obat

821 Data
Apixaban Apixaban may increase the anticoagulant activities of Beraprost.
Dabigatran etexilate Dabigatran etexilate may increase the anticoagulant activities of Beraprost.
Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Beraprost.
Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Beraprost is combined with Deferasirox.
Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Beraprost.
Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Beraprost.
Rivaroxaban Beraprost may increase the anticoagulant activities of Rivaroxaban.
Sugammadex The risk or severity of bleeding and hemorrhage can be increased when Beraprost is combined with Sugammadex.
Tibolone Tibolone may increase the anticoagulant activities of Beraprost.
Urokinase Urokinase may increase the anticoagulant activities of Beraprost.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Beraprost.
Ursodeoxycholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of adverse effects can be increased when Beraprost is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of adverse effects can be increased when Beraprost is combined with Cholic Acid.
Glycocholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Taurocholic acid.
Obeticholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of adverse effects can be increased when Beraprost is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of adverse effects can be increased when Beraprost is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of adverse effects can be increased when Beraprost is combined with Hyodeoxycholic Acid.
Glucosamine Glucosamine may increase the antiplatelet activities of Beraprost.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Beraprost is combined with Ibritumomab tiuxetan.
Obinutuzumab The risk or severity of adverse effects can be increased when Beraprost is combined with Obinutuzumab.
Tipranavir Tipranavir may increase the antiplatelet activities of Beraprost.
Vitamin E Vitamin E may increase the antiplatelet activities of Beraprost.
Mifepristone The serum concentration of Beraprost can be increased when it is combined with Mifepristone.
Ginkgo biloba Ginkgo biloba may increase the anticoagulant activities of Beraprost.
Ifosfamide The risk or severity of bleeding can be increased when Ifosfamide is combined with Beraprost.
Quinine The therapeutic efficacy of Beraprost can be increased when used in combination with Quinine.
Quinidine The therapeutic efficacy of Beraprost can be increased when used in combination with Quinidine.
Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Beraprost.
Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Beraprost.
Pentoxifylline The therapeutic efficacy of Beraprost can be increased when used in combination with Pentoxifylline.
Pentosan polysulfate The risk or severity of adverse effects can be increased when Pentosan polysulfate is combined with Beraprost.
Levocarnitine The therapeutic efficacy of Beraprost can be increased when used in combination with Levocarnitine.
Diethylstilbestrol Diethylstilbestrol may decrease the anticoagulant activities of Beraprost.
Chlorotrianisene Chlorotrianisene may decrease the anticoagulant activities of Beraprost.
Conjugated estrogens Conjugated estrogens may decrease the anticoagulant activities of Beraprost.
Mestranol The risk or severity of adverse effects can be increased when Mestranol is combined with Beraprost.
Estrone sulfate Estrone sulfate may decrease the anticoagulant activities of Beraprost.
Quinestrol Quinestrol may decrease the anticoagulant activities of Beraprost.
Hexestrol Hexestrol may decrease the anticoagulant activities of Beraprost.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Beraprost.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Beraprost.
Polyestradiol phosphate Polyestradiol phosphate may decrease the anticoagulant activities of Beraprost.
Esterified estrogens Esterified estrogens may decrease the anticoagulant activities of Beraprost.
Zeranol Zeranol may decrease the anticoagulant activities of Beraprost.
Equol Equol may decrease the anticoagulant activities of Beraprost.
Methallenestril Methallenestril may decrease the anticoagulant activities of Beraprost.
Epimestrol Epimestrol may decrease the anticoagulant activities of Beraprost.
Moxestrol Moxestrol may decrease the anticoagulant activities of Beraprost.
Estradiol acetate Estradiol acetate may decrease the anticoagulant activities of Beraprost.
Estradiol benzoate Estradiol benzoate may decrease the anticoagulant activities of Beraprost.
Estradiol cypionate Estradiol cypionate may decrease the anticoagulant activities of Beraprost.
Estradiol valerate Estradiol valerate may decrease the anticoagulant activities of Beraprost.
Biochanin A Biochanin A may decrease the anticoagulant activities of Beraprost.
Formononetin Formononetin may decrease the anticoagulant activities of Beraprost.
Estriol Estriol may decrease the anticoagulant activities of Beraprost.
Limaprost The risk or severity of adverse effects can be increased when Limaprost is combined with Beraprost.
Icosapent The risk or severity of bleeding and hemorrhage can be increased when Icosapent is combined with Beraprost.
Mesalazine The risk or severity of bleeding can be increased when Mesalazine is combined with Beraprost.
Indomethacin The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Beraprost.
Nabumetone The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Beraprost.
Ketorolac The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Beraprost.
Tenoxicam The risk or severity of bleeding and hemorrhage can be increased when Tenoxicam is combined with Beraprost.
Celecoxib The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Beraprost.
Tolmetin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Beraprost.
Rofecoxib The risk or severity of bleeding and hemorrhage can be increased when Rofecoxib is combined with Beraprost.
Piroxicam The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Beraprost.
Fenoprofen The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Beraprost.
Valdecoxib The risk or severity of bleeding and hemorrhage can be increased when Valdecoxib is combined with Beraprost.
Diclofenac The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Beraprost.
Sulindac The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Beraprost.
Flurbiprofen The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Beraprost.
Etodolac The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Beraprost.
Mefenamic acid The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Beraprost.
Naproxen The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Beraprost.
Sulfasalazine The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Beraprost.
Phenylbutazone The risk or severity of bleeding and hemorrhage can be increased when Phenylbutazone is combined with Beraprost.
Meloxicam The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Beraprost.
Carprofen The risk or severity of bleeding and hemorrhage can be increased when Carprofen is combined with Beraprost.
Diflunisal The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Beraprost.
Salicylic acid The risk or severity of bleeding and hemorrhage can be increased when Salicylic acid is combined with Beraprost.
Meclofenamic acid The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Beraprost.
Oxaprozin The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Beraprost.
Ketoprofen The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Beraprost.
Balsalazide The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Beraprost.
Olsalazine The risk or severity of bleeding can be increased when Olsalazine is combined with Beraprost.
Lumiracoxib The risk or severity of bleeding and hemorrhage can be increased when Lumiracoxib is combined with Beraprost.
Magnesium salicylate The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with Beraprost.
Salsalate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Beraprost.
Choline magnesium trisalicylate The risk or severity of bleeding and hemorrhage can be increased when Choline magnesium trisalicylate is combined with Beraprost.
Antrafenine The risk or severity of bleeding and hemorrhage can be increased when Antrafenine is combined with Beraprost.
Aminophenazone The risk or severity of bleeding and hemorrhage can be increased when Aminophenazone is combined with Beraprost.
Antipyrine The risk or severity of bleeding and hemorrhage can be increased when Antipyrine is combined with Beraprost.
Tiaprofenic acid The risk or severity of bleeding and hemorrhage can be increased when Tiaprofenic acid is combined with Beraprost.

Target Protein

Prostacyclin receptor PTGIR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17620284
    Lin H, Lee JL, Hou HH, Chung CP, Hsu SP, Juan SH: Molecular mechanisms of the antiproliferative effect of beraprost, a prostacyclin agonist, in murine vascular smooth muscle cells. J Cell Physiol. 2008 Feb;214(2):434-41.
  • PMID: 11790158
    Melian EB, Goa KL: Beraprost: a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension. Drugs. 2002;62(1):107-33.

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