Vintafolide

DB05168

small molecule investigational

Deskripsi

Vintafolide is a folate-targeted chemotherapeutic conjugate (folate vitamin + vinca alkaloid) in clinical stage development as a treatment for folate-receptor positive cancers.

Struktur Molekul 2D

Berat 1917.06
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

102 Data
Posaconazole The metabolism of Vintafolide can be decreased when combined with Posaconazole.
Voriconazole The metabolism of Vintafolide can be decreased when combined with Voriconazole.
Lopinavir The serum concentration of Vintafolide can be increased when it is combined with Lopinavir.
Erythromycin The serum concentration of Vintafolide can be increased when it is combined with Erythromycin.
Sirolimus The serum concentration of Vintafolide can be increased when it is combined with Sirolimus.
Dirithromycin The serum concentration of Vintafolide can be increased when it is combined with Dirithromycin.
Telithromycin The serum concentration of Vintafolide can be increased when it is combined with Telithromycin.
Candicidin The serum concentration of Vintafolide can be increased when it is combined with Candicidin.
Clarithromycin The serum concentration of Vintafolide can be increased when it is combined with Clarithromycin.
Josamycin The serum concentration of Vintafolide can be increased when it is combined with Josamycin.
Everolimus The serum concentration of Vintafolide can be increased when it is combined with Everolimus.
Epothilone D The serum concentration of Vintafolide can be increased when it is combined with Epothilone D.
Patupilone The serum concentration of Vintafolide can be increased when it is combined with Patupilone.
6-Deoxyerythronolide B The serum concentration of Vintafolide can be increased when it is combined with 6-Deoxyerythronolide B.
Ixabepilone The serum concentration of Vintafolide can be increased when it is combined with Ixabepilone.
KOS-1584 The serum concentration of Vintafolide can be increased when it is combined with KOS-1584.
Ridaforolimus The serum concentration of Vintafolide can be increased when it is combined with Ridaforolimus.
Temsirolimus The serum concentration of Vintafolide can be increased when it is combined with Temsirolimus.
AVE9633 The serum concentration of Vintafolide can be increased when it is combined with AVE9633.
Coltuximab ravtansine The serum concentration of Vintafolide can be increased when it is combined with Coltuximab ravtansine.
Cethromycin The serum concentration of Vintafolide can be increased when it is combined with Cethromycin.
Mitemcinal The serum concentration of Vintafolide can be increased when it is combined with Mitemcinal.
Brefeldin A The serum concentration of Vintafolide can be increased when it is combined with Brefeldin A.
Solithromycin The serum concentration of Vintafolide can be increased when it is combined with Solithromycin.
Kitasamycin The serum concentration of Vintafolide can be increased when it is combined with Kitasamycin.
Carbomycin The serum concentration of Vintafolide can be increased when it is combined with Carbomycin.
Doramectin The serum concentration of Vintafolide can be increased when it is combined with Doramectin.
Eprinomectin The serum concentration of Vintafolide can be increased when it is combined with Eprinomectin.
Oleandomycin The serum concentration of Vintafolide can be increased when it is combined with Oleandomycin.
Selamectin The serum concentration of Vintafolide can be increased when it is combined with Selamectin.
Tildipirosin The serum concentration of Vintafolide can be increased when it is combined with Tildipirosin.
Tilmicosin The serum concentration of Vintafolide can be increased when it is combined with Tilmicosin.
Tylosin The serum concentration of Vintafolide can be increased when it is combined with Tylosin.
Tylvalosin The serum concentration of Vintafolide can be increased when it is combined with Tylvalosin.
Bryostatin 1 The serum concentration of Vintafolide can be increased when it is combined with Bryostatin 1.
Lorvotuzumab mertansine The serum concentration of Vintafolide can be increased when it is combined with Lorvotuzumab mertansine.
Epofolate The serum concentration of Vintafolide can be increased when it is combined with Epofolate.
Sagopilone The serum concentration of Vintafolide can be increased when it is combined with Sagopilone.
Troleandomycin The serum concentration of Vintafolide can be increased when it is combined with Troleandomycin.
Miocamycin The serum concentration of Vintafolide can be increased when it is combined with Miocamycin.
Flurithromycin The serum concentration of Vintafolide can be increased when it is combined with Flurithromycin.
Rokitamycin The serum concentration of Vintafolide can be increased when it is combined with Rokitamycin.
Midecamycin The serum concentration of Vintafolide can be increased when it is combined with Midecamycin.
Clindamycin The serum concentration of Vintafolide can be increased when it is combined with Clindamycin.
Mepartricin The serum concentration of Vintafolide can be increased when it is combined with Mepartricin.
Mitomycin The risk or severity of bronchospasm, shortness of breath, and dyspnea can be increased when Vintafolide is combined with Mitomycin.
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vintafolide.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Vintafolide.
Pegfilgrastim The risk or severity of peripheral neuropathy can be increased when Pegfilgrastim is combined with Vintafolide.
Sargramostim The risk or severity of peripheral neuropathy can be increased when Sargramostim is combined with Vintafolide.
Filgrastim The risk or severity of peripheral neuropathy can be increased when Filgrastim is combined with Vintafolide.
Romiplostim The risk or severity of peripheral neuropathy can be increased when Romiplostim is combined with Vintafolide.
Regramostim The risk or severity of peripheral neuropathy can be increased when Regramostim is combined with Vintafolide.
Maxy-G34 The risk or severity of peripheral neuropathy can be increased when Maxy-G34 is combined with Vintafolide.
Thrombopoietin The risk or severity of peripheral neuropathy can be increased when Thrombopoietin is combined with Vintafolide.
Ancestim The risk or severity of peripheral neuropathy can be increased when Ancestim is combined with Vintafolide.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vintafolide.
Epoetin delta The risk or severity of peripheral neuropathy can be increased when Epoetin delta is combined with Vintafolide.
Muplestim The risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vintafolide.
Balugrastim The risk or severity of peripheral neuropathy can be increased when Balugrastim is combined with Vintafolide.
Lenograstim The risk or severity of peripheral neuropathy can be increased when Lenograstim is combined with Vintafolide.
Lipegfilgrastim The risk or severity of peripheral neuropathy can be increased when Lipegfilgrastim is combined with Vintafolide.
Leridistim The risk or severity of peripheral neuropathy can be increased when Leridistim is combined with Vintafolide.
Pegteograstim The risk or severity of peripheral neuropathy can be increased when Pegteograstim is combined with Vintafolide.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Vintafolide.
Eflapegrastim The risk or severity of peripheral neuropathy can be increased when Eflapegrastim is combined with Vintafolide.
Lidocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Vintafolide.
Ambroxol The risk or severity of methemoglobinemia can be increased when Vintafolide is combined with Ambroxol.

Target Protein

Folate receptor alpha FOLR1
Folate receptor beta FOLR2
Folate receptor gamma FOLR3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17551919
    Leamon CP, Reddy JA, Vlahov IR, Westrick E, Parker N, Nicoson JS, Vetzel M: Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145. Int J Cancer. 2007 Oct 1;121(7):1585-92.
  • PMID: 17483358
    Reddy JA, Dorton R, Westrick E, Dawson A, Smith T, Xu LC, Vetzel M, Kleindl P, Vlahov IR, Leamon CP: Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate. Cancer Res. 2007 May 1;67(9):4434-42.

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Sekuens Gen/Protein (FASTA)

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