Peringatan Keamanan

Direct clearance of free virus and antibody-dependent cellular cytotoxicity of virus-infected cells appear to be the major mechanisms that contribute to the anti-viral effect of bavituximab

Bavituximab

DB05136

biotech investigational

Deskripsi

Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 30 Hrs
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

411 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Bavituximab.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Bavituximab.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Bavituximab.
Estrone Estrone may increase the thrombogenic activities of Bavituximab.
Estradiol Estradiol may increase the thrombogenic activities of Bavituximab.
Dienestrol Dienestrol may increase the thrombogenic activities of Bavituximab.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Bavituximab.
Mestranol Mestranol may increase the thrombogenic activities of Bavituximab.
Estriol Estriol may increase the thrombogenic activities of Bavituximab.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Bavituximab.
Quinestrol Quinestrol may increase the thrombogenic activities of Bavituximab.
Hexestrol Hexestrol may increase the thrombogenic activities of Bavituximab.
Tibolone Tibolone may increase the thrombogenic activities of Bavituximab.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Bavituximab.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Bavituximab.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Bavituximab.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Bavituximab.
Zeranol Zeranol may increase the thrombogenic activities of Bavituximab.
Equol Equol may increase the thrombogenic activities of Bavituximab.
Promestriene Promestriene may increase the thrombogenic activities of Bavituximab.
Methallenestril Methallenestril may increase the thrombogenic activities of Bavituximab.
Epimestrol Epimestrol may increase the thrombogenic activities of Bavituximab.
Moxestrol Moxestrol may increase the thrombogenic activities of Bavituximab.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Bavituximab.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Bavituximab.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Bavituximab.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Bavituximab.
Biochanin A Biochanin A may increase the thrombogenic activities of Bavituximab.
Formononetin Formononetin may increase the thrombogenic activities of Bavituximab.
Estetrol Estetrol may increase the thrombogenic activities of Bavituximab.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Bavituximab.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Bavituximab.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Bavituximab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Bavituximab.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Bavituximab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Bavituximab.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Bavituximab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Bavituximab.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Bavituximab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Bavituximab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Bavituximab.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Bavituximab.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Bavituximab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Bavituximab.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Bavituximab.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Bavituximab.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Bavituximab.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Bavituximab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Bavituximab.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with Bavituximab.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with Bavituximab.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Bavituximab.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with Bavituximab.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with Bavituximab.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Bavituximab.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with Bavituximab.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with Bavituximab.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with Bavituximab.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with Bavituximab.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Bavituximab.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with Bavituximab.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with Bavituximab.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with Bavituximab.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with Bavituximab.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with Bavituximab.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Bavituximab.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with Bavituximab.
Fontolizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Bavituximab.
CR002 The risk or severity of adverse effects can be increased when Bavituximab is combined with CR002.
Rozrolimupab The risk or severity of adverse effects can be increased when Bavituximab is combined with Rozrolimupab.
Girentuximab The risk or severity of adverse effects can be increased when Bavituximab is combined with Girentuximab.
Obiltoxaximab The risk or severity of adverse effects can be increased when Bavituximab is combined with Obiltoxaximab.
XTL-001 The risk or severity of adverse effects can be increased when Bavituximab is combined with XTL-001.
NAV 1800 The risk or severity of adverse effects can be increased when Bavituximab is combined with NAV 1800.
Briakinumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Briakinumab.
Otelixizumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Otelixizumab.
AMG 108 The risk or severity of adverse effects can be increased when Bavituximab is combined with AMG 108.
Iratumumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Iratumumab.
Enokizumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Enokizumab.
Ramucirumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Ramucirumab.
Farletuzumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Farletuzumab.
Veltuzumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Veltuzumab.
Ustekinumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Ustekinumab.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Bavituximab is combined with Trastuzumab emtansine.
PRO-542 The risk or severity of adverse effects can be increased when Bavituximab is combined with PRO-542.
TNX-901 The risk or severity of adverse effects can be increased when Bavituximab is combined with TNX-901.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Bavituximab is combined with Inotuzumab ozogamicin.
RI 624 The risk or severity of adverse effects can be increased when Bavituximab is combined with RI 624.
Stamulumab The risk or severity of adverse effects can be increased when Bavituximab is combined with MYO-029.
CT-011 The risk or severity of adverse effects can be increased when Bavituximab is combined with CT-011.
Leronlimab The risk or severity of adverse effects can be increased when Bavituximab is combined with Leronlimab.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when Bavituximab is combined with Glembatumumab vedotin.
Olaratumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Olaratumab.
IPH 2101 The risk or severity of adverse effects can be increased when Bavituximab is combined with IPH 2101.
TB-402 The risk or severity of adverse effects can be increased when Bavituximab is combined with TB-402.
Caplacizumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Caplacizumab.
IMC-1C11 The risk or severity of adverse effects can be increased when Bavituximab is combined with IMC-1C11.
Eldelumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Eldelumab.
Lumiliximab The risk or severity of adverse effects can be increased when Bavituximab is combined with Lumiliximab.
Canakinumab The risk or severity of adverse effects can be increased when Bavituximab is combined with Canakinumab.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17785577
    He J, Luster TA, Thorpe PE: Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids. Clin Cancer Res. 2007 Sep 1;13(17):5211-8.

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