Fontolizumab

DB05111

biotech investigational

Deskripsi

Fontolizumab (marketed under the trade name HuZAF™) is a humanized monoclonal antibody which is used as an immunosuppressive drug to treat Crohn's disease.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

373 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Fontolizumab.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Fontolizumab.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Fontolizumab.
Estrone Estrone may increase the thrombogenic activities of Fontolizumab.
Estradiol Estradiol may increase the thrombogenic activities of Fontolizumab.
Dienestrol Dienestrol may increase the thrombogenic activities of Fontolizumab.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Fontolizumab.
Mestranol Mestranol may increase the thrombogenic activities of Fontolizumab.
Estriol Estriol may increase the thrombogenic activities of Fontolizumab.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Fontolizumab.
Quinestrol Quinestrol may increase the thrombogenic activities of Fontolizumab.
Hexestrol Hexestrol may increase the thrombogenic activities of Fontolizumab.
Tibolone Tibolone may increase the thrombogenic activities of Fontolizumab.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Fontolizumab.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Fontolizumab.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Fontolizumab.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Fontolizumab.
Zeranol Zeranol may increase the thrombogenic activities of Fontolizumab.
Equol Equol may increase the thrombogenic activities of Fontolizumab.
Promestriene Promestriene may increase the thrombogenic activities of Fontolizumab.
Methallenestril Methallenestril may increase the thrombogenic activities of Fontolizumab.
Epimestrol Epimestrol may increase the thrombogenic activities of Fontolizumab.
Moxestrol Moxestrol may increase the thrombogenic activities of Fontolizumab.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Fontolizumab.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Fontolizumab.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Fontolizumab.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Fontolizumab.
Biochanin A Biochanin A may increase the thrombogenic activities of Fontolizumab.
Formononetin Formononetin may increase the thrombogenic activities of Fontolizumab.
Estetrol Estetrol may increase the thrombogenic activities of Fontolizumab.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Fontolizumab.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Fontolizumab.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Fontolizumab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Fontolizumab.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Fontolizumab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Fontolizumab.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Fontolizumab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Fontolizumab.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Fontolizumab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Fontolizumab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Fontolizumab.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Fontolizumab.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Fontolizumab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Fontolizumab.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Fontolizumab.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Fontolizumab.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Fontolizumab.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Fontolizumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Fontolizumab.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with Fontolizumab.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with Fontolizumab.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Fontolizumab.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with Fontolizumab.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with Fontolizumab.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Fontolizumab.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with Fontolizumab.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with Fontolizumab.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with Fontolizumab.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with Fontolizumab.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Fontolizumab.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with Fontolizumab.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with Fontolizumab.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with Fontolizumab.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with Fontolizumab.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with Fontolizumab.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Fontolizumab.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with Fontolizumab.
Bavituximab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Bavituximab.
CR002 The risk or severity of adverse effects can be increased when Fontolizumab is combined with CR002.
Rozrolimupab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Rozrolimupab.
Girentuximab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Girentuximab.
Obiltoxaximab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Obiltoxaximab.
XTL-001 The risk or severity of adverse effects can be increased when Fontolizumab is combined with XTL-001.
NAV 1800 The risk or severity of adverse effects can be increased when Fontolizumab is combined with NAV 1800.
Briakinumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Briakinumab.
Otelixizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Otelixizumab.
AMG 108 The risk or severity of adverse effects can be increased when Fontolizumab is combined with AMG 108.
Iratumumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Iratumumab.
Enokizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Enokizumab.
Ramucirumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Ramucirumab.
Farletuzumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Farletuzumab.
Veltuzumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Veltuzumab.
Ustekinumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Ustekinumab.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Fontolizumab is combined with Trastuzumab emtansine.
PRO-542 The risk or severity of adverse effects can be increased when Fontolizumab is combined with PRO-542.
TNX-901 The risk or severity of adverse effects can be increased when Fontolizumab is combined with TNX-901.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Fontolizumab is combined with Inotuzumab ozogamicin.
RI 624 The risk or severity of adverse effects can be increased when Fontolizumab is combined with RI 624.
Stamulumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with MYO-029.
CT-011 The risk or severity of adverse effects can be increased when Fontolizumab is combined with CT-011.
Leronlimab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Leronlimab.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when Fontolizumab is combined with Glembatumumab vedotin.
Olaratumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Olaratumab.
IPH 2101 The risk or severity of adverse effects can be increased when Fontolizumab is combined with IPH 2101.
TB-402 The risk or severity of adverse effects can be increased when Fontolizumab is combined with TB-402.
Caplacizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Caplacizumab.
IMC-1C11 The risk or severity of adverse effects can be increased when Fontolizumab is combined with IMC-1C11.
Eldelumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Eldelumab.
Lumiliximab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Lumiliximab.
Canakinumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Canakinumab.

Target Protein

Interferon gamma IFNG

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16507585
    Hommes DW, Mikhajlova TL, Stoinov S, Stimac D, Vucelic B, Lonovics J, Zakuciova M, D'Haens G, Van Assche G, Ba S, Lee S, Pearce T: Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Gut. 2006 Aug;55(8):1131-7. Epub 2006 Feb 28.
  • PMID: 16492717
    Reinisch W, Hommes DW, Van Assche G, Colombel JF, Gendre JP, Oldenburg B, Teml A, Geboes K, Ding H, Zhang L, Tang M, Cheng M, van Deventer SJ, Rutgeerts P, Pearce T: A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease. Gut. 2006 Aug;55(8):1138-44. Epub 2006 Feb 21.
  • PMID: 15912969
    Dumont FJ: Fontolizumab Protein Design Labs. Curr Opin Investig Drugs. 2005 May;6(5):537-44.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • HuZAF

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