16-Bromoepiandrosterone

DB05107

small molecule investigational

Deskripsi

16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide. It is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity in laboratory tests.

Struktur Molekul 2D

Berat 369.336
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

63 Data
Flunisolide The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Flunisolide.
Beclomethasone dipropionate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Beclomethasone dipropionate.
Betamethasone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Betamethasone.
Fluticasone propionate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluocinolone acetonide.
Triamcinolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Triamcinolone.
Prednisone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Prednisone.
Fludrocortisone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fludrocortisone.
Hydrocortisone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Hydrocortisone.
Prednisolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Prednisolone.
Methylprednisolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Methylprednisolone.
Trilostane The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Trilostane.
Budesonide The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Budesonide.
Dexamethasone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Dexamethasone.
Corticotropin The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Corticotropin.
Cortisone acetate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Cortisone acetate.
Paramethasone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Paramethasone.
Ciclesonide The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Ciclesonide.
Aldosterone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Aldosterone.
Fluticasone furoate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluticasone furoate.
Fluprednidene The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluprednidene.
Tixocortol The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Tixocortol.
Fluprednisolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluprednisolone.
Meprednisone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Meprednisone.
Dexamethasone isonicotinate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Dexamethasone isonicotinate.
Melengestrol The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Melengestrol.
Deflazacort The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Deflazacort.
Cortivazol The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Cortivazol.
Prednylidene The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Prednylidene.
Fluocortin The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluocortin.
Fluperolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluperolone.
Cloprednol The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Cloprednol.
Fluclorolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluclorolone.
Fluticasone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluticasone.
Mometasone furoate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Mometasone furoate.
Hydrocortisone acetate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Hydrocortisone acetate.
Hydrocortisone cypionate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Hydrocortisone cypionate.
Hydrocortisone succinate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Hydrocortisone succinate.
Prednisolone phosphate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Prednisolone phosphate.
Prednisolone hemisuccinate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Prednisolone hemisuccinate.
Methylprednisolone hemisuccinate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Methylprednisolone hemisuccinate.
Prednisone acetate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Prednisone acetate.
Clocortolone acetate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Clocortolone acetate.
Melengestrol acetate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Melengestrol acetate.
Betamethasone phosphate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Betamethasone phosphate.
Cortisone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Cortisone.
Clobetasol propionate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Clobetasol propionate.
Fluocinonide The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluocinonide.
Hydrocortisone butyrate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Hydrocortisone butyrate.
Desoximetasone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Desoximetasone.
Mometasone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Mometasone.
Fluocortolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluocortolone.
Prednisolone acetate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Prednisolone acetate.
Fluorometholone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluorometholone.
Difluocortolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Difluocortolone.
Flumethasone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Flumethasone.
Methylprednisolone aceponate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Methylprednisolone aceponate.
Dexamethasone acetate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Dexamethasone acetate.
Corticotropin zinc hydroxide The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Corticotropin zinc hydroxide.
Fluocortolone pivalate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluocortolone pivalate.
Fluocortolone caproate The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Fluocortolone caproate.
Desoxycortone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Desoxycortone.
Vamorolone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Vamorolone.

Target Protein

Androgen receptor AR
Glucose-6-phosphate 1-dehydrogenase G6PD

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17297029
    Frincke JM, Stickney DR, Onizuka-Handa N, Garsd A, Reading C, Krudsood S, Wilairatana P, Looareesuwan S: Reduction of parasite levels in patients with uncomplicated malaria by treatment with HE2000. Am J Trop Med Hyg. 2007 Feb;76(2):232-6.
  • PMID: 17002607
    Reading C, Dowding C, Schramm B, Garsd A, Onizuka-Handa N, Stickney D, Frincke J: Improvement in immune parameters and human immunodeficiency virus-1 viral response in individuals treated with 16alpha-bromoepiandrosterone (HE2000). Clin Microbiol Infect. 2006 Nov;12(11):1082-8.
  • PMID: 11366467
    Frincke J: HE2000 begins clinical trials: interview with James Frincke, Ph.D. Interview by John S. James. AIDS Treat News. 1999 Jun 4;(No 320):4-7.
  • PMID: 10851716
    Authors unspecified: HE2000 corrects immune system dysregulation in HIV-positive patients. AIDS Read. 2000 May;10(5):282.
  • PMID: 10842861
    Authors unspecified: HE2000 shows efficacy. AIDS Patient Care STDS. 1999 Jun;13(6):375.

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