Labetuzumab

DB05097

biotech investigational

Deskripsi

Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth. It is used in radioimmunotherapy.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

412 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Labetuzumab.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Labetuzumab.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Labetuzumab.
Estrone Estrone may increase the thrombogenic activities of Labetuzumab.
Estradiol Estradiol may increase the thrombogenic activities of Labetuzumab.
Dienestrol Dienestrol may increase the thrombogenic activities of Labetuzumab.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Labetuzumab.
Mestranol Mestranol may increase the thrombogenic activities of Labetuzumab.
Estriol Estriol may increase the thrombogenic activities of Labetuzumab.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Labetuzumab.
Quinestrol Quinestrol may increase the thrombogenic activities of Labetuzumab.
Hexestrol Hexestrol may increase the thrombogenic activities of Labetuzumab.
Tibolone Tibolone may increase the thrombogenic activities of Labetuzumab.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Labetuzumab.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Labetuzumab.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Labetuzumab.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Labetuzumab.
Zeranol Zeranol may increase the thrombogenic activities of Labetuzumab.
Equol Equol may increase the thrombogenic activities of Labetuzumab.
Promestriene Promestriene may increase the thrombogenic activities of Labetuzumab.
Methallenestril Methallenestril may increase the thrombogenic activities of Labetuzumab.
Epimestrol Epimestrol may increase the thrombogenic activities of Labetuzumab.
Moxestrol Moxestrol may increase the thrombogenic activities of Labetuzumab.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Labetuzumab.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Labetuzumab.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Labetuzumab.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Labetuzumab.
Biochanin A Biochanin A may increase the thrombogenic activities of Labetuzumab.
Formononetin Formononetin may increase the thrombogenic activities of Labetuzumab.
Estetrol Estetrol may increase the thrombogenic activities of Labetuzumab.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Labetuzumab.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Labetuzumab.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Labetuzumab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Labetuzumab.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Labetuzumab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Labetuzumab.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Labetuzumab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Labetuzumab.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Labetuzumab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Labetuzumab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Labetuzumab.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Labetuzumab.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Labetuzumab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Labetuzumab.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Labetuzumab.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Labetuzumab.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Labetuzumab.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Labetuzumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Labetuzumab.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with Labetuzumab.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with Labetuzumab.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Labetuzumab.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with Labetuzumab.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with Labetuzumab.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Labetuzumab.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with Labetuzumab.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with Labetuzumab.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with Labetuzumab.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with Labetuzumab.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Labetuzumab.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with Labetuzumab.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with Labetuzumab.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with Labetuzumab.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with Labetuzumab.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with Labetuzumab.
Matuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Matuzumab.
Fontolizumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Fontolizumab.
Bavituximab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Bavituximab.
CR002 The risk or severity of adverse effects can be increased when Labetuzumab is combined with CR002.
Rozrolimupab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Rozrolimupab.
Girentuximab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Girentuximab.
Obiltoxaximab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Obiltoxaximab.
XTL-001 The risk or severity of adverse effects can be increased when Labetuzumab is combined with XTL-001.
NAV 1800 The risk or severity of adverse effects can be increased when Labetuzumab is combined with NAV 1800.
Briakinumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Briakinumab.
Otelixizumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Otelixizumab.
AMG 108 The risk or severity of adverse effects can be increased when Labetuzumab is combined with AMG 108.
Iratumumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Iratumumab.
Enokizumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Enokizumab.
Ramucirumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Ramucirumab.
Farletuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Farletuzumab.
Veltuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Veltuzumab.
Ustekinumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Ustekinumab.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Labetuzumab is combined with Trastuzumab emtansine.
PRO-542 The risk or severity of adverse effects can be increased when Labetuzumab is combined with PRO-542.
TNX-901 The risk or severity of adverse effects can be increased when Labetuzumab is combined with TNX-901.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Labetuzumab is combined with Inotuzumab ozogamicin.
RI 624 The risk or severity of adverse effects can be increased when Labetuzumab is combined with RI 624.
Stamulumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with MYO-029.
CT-011 The risk or severity of adverse effects can be increased when Labetuzumab is combined with CT-011.
Leronlimab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Leronlimab.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when Labetuzumab is combined with Glembatumumab vedotin.
Olaratumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Olaratumab.
IPH 2101 The risk or severity of adverse effects can be increased when Labetuzumab is combined with IPH 2101.
TB-402 The risk or severity of adverse effects can be increased when Labetuzumab is combined with TB-402.
Caplacizumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Caplacizumab.
IMC-1C11 The risk or severity of adverse effects can be increased when Labetuzumab is combined with IMC-1C11.
Eldelumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Eldelumab.
Lumiliximab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Lumiliximab.
Canakinumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Canakinumab.

Target Protein

Cell adhesion molecule CEACAM5 CEACAM5

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16170184
    Liersch T, Meller J, Kulle B, Behr TM, Markus P, Langer C, Ghadimi BM, Wegener WA, Kovacs J, Horak ID, Becker H, Goldenberg DM: Phase II trial of carcinoembryonic antigen radioimmunotherapy with 131I-labetuzumab after salvage resection of colorectal metastases in the liver: five-year safety and efficacy results. J Clin Oncol. 2005 Sep 20;23(27):6763-70.
  • PMID: 17570017
    Liersch T, Meller J, Bittrich M, Kulle B, Becker H, Goldenberg DM: Update of carcinoembryonic antigen radioimmunotherapy with (131)I-labetuzumab after salvage resection of colorectal liver metastases: comparison of outcome to a contemporaneous control group. Ann Surg Oncol. 2007 Sep;14(9):2577-90. Epub 2007 Jun 15.

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