Cimicoxib

DB05095

small molecule investigational

Deskripsi

Cimicoxib is a selective COX-2 inhibitor being developed by Affectis as a treatment for depression and schizophrenia. If approved, Cimicoxib would be the first drug in decades to treat depression by a new mechanism of action.

Struktur Molekul 2D

Berat 381.809
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1404 Data
Amlodipine Cimicoxib may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Cimicoxib.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Cimicoxib.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Cimicoxib.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Cimicoxib.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Cimicoxib.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Cimicoxib.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Cimicoxib.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Cimicoxib.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Cimicoxib.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Cimicoxib.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Cimicoxib.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Cimicoxib.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Cimicoxib.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Cimicoxib.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Cimicoxib.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Cimicoxib.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Cimicoxib.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Cimicoxib.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Cimicoxib.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Cimicoxib.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Cimicoxib.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Cimicoxib.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Cimicoxib.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Cimicoxib.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Cimicoxib.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Cimicoxib.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Cimicoxib.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Cimicoxib.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Cimicoxib.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Cimicoxib.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Cimicoxib.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Cimicoxib.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Cimicoxib.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Cimicoxib.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Cimicoxib.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Cimicoxib.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Cimicoxib.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Cimicoxib.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Cimicoxib.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Cimicoxib.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Cimicoxib.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Cimicoxib.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Cimicoxib.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Cimicoxib.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Cimicoxib.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Cimicoxib.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Cimicoxib.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Cimicoxib.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Cimicoxib.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Cimicoxib.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Cimicoxib.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Cimicoxib.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Cimicoxib.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Cimicoxib.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Cimicoxib.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Cimicoxib.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Cimicoxib.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Cimicoxib.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Cimicoxib.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Cimicoxib.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Cimicoxib.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Cimicoxib.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Cimicoxib.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Cimicoxib.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Cimicoxib.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Cimicoxib.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Cimicoxib.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Cimicoxib.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Cimicoxib.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Cimicoxib.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Cimicoxib.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Cimicoxib.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Cimicoxib.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Cimicoxib.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Cimicoxib.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Cimicoxib.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Cimicoxib.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Cimicoxib.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Cimicoxib.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Cimicoxib.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Cimicoxib.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Cimicoxib.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Cimicoxib.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Cimicoxib.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Cimicoxib.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Cimicoxib.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Cimicoxib.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Cimicoxib.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Cimicoxib.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Cimicoxib.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Cimicoxib.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Cimicoxib.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Cimicoxib.
Iproniazid The risk or severity of hypertension can be increased when Iproniazid is combined with Cimicoxib.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Cimicoxib.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Lysergic acid diethylamide is combined with Cimicoxib.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Cimicoxib.
Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Cimicoxib.
Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Cimicoxib.

Target Protein

Prostaglandin G/H synthase 2 PTGS2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17335184
    Chegaev K, Lazzarato L, Tosco P, Cena C, Marini E, Rolando B, Carrupt PA, Fruttero R, Gasco A: NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties. J Med Chem. 2007 Apr 5;50(7):1449-57. Epub 2007 Mar 3.
  • PMID: 15481993
    Almansa C, Bartroli J, Belloc J, Cavalcanti FL, Ferrando R, Gomez LA, Ramis I, Carceller E, Merlos M, Garcia-Rafanell J: New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs. J Med Chem. 2004 Oct 21;47(22):5579-82.

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Sekuens Gen/Protein (FASTA)

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