Peringatan Keamanan

"Mechanism of fenretinide (4-HPR)-induced cell death"

Fenretinide

DB05076

small molecule investigational

Deskripsi

A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.

Struktur Molekul 2D

Berat 391.5457
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

85 Data
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Fenretinide.
Estradiol The therapeutic efficacy of Estradiol can be decreased when used in combination with Fenretinide.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Fenretinide.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Fenretinide.
Estradiol cypionate The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Fenretinide.
Estradiol valerate The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Fenretinide.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Fenretinide.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Fenretinide.
Megestrol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Fenretinide.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Fenretinide.
Medroxyprogesterone acetate The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Fenretinide.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Fenretinide.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Fenretinide.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Fenretinide.
Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Fenretinide.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Fenretinide.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Fenretinide.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Fenretinide.
Dienogest The therapeutic efficacy of Dienogest can be decreased when used in combination with Fenretinide.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Fenretinide.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Fenretinide.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Fenretinide.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Fenretinide.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Fenretinide.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Fenretinide.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Fenretinide.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Fenretinide.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Fenretinide.
Vitamin A The risk or severity of adverse effects can be increased when Vitamin A is combined with Fenretinide.
Valproic acid Valproic acid may increase the Pseudotumor Cerebri activities of Fenretinide.
Doxycycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Doxycycline.
Clomocycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Clomocycline.
Tigecycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Tigecycline.
Oxytetracycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Oxytetracycline.
Demeclocycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Demeclocycline.
Tetracycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Tetracycline.
Metacycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Metacycline.
Minocycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Minocycline.
Rolitetracycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Rolitetracycline.
Sarecycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Sarecycline.
Eravacycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Eravacycline.
Omadacycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Omadacycline.
Penimepicycline The risk or severity of pseudotumor cerebri can be increased when Fenretinide is combined with Penimepicycline.
Methotrexate The risk or severity of adverse effects can be increased when Methotrexate is combined with Fenretinide.
Lymecycline The risk or severity of pseudotumor cerebri can be increased when Lymecycline is combined with Fenretinide.
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Fenretinide.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Fenretinide.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Fenretinide.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Fenretinide.
Palovarotene The risk or severity of adverse effects can be increased when Fenretinide is combined with Palovarotene.
Lidocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Fenretinide.
Ambroxol The risk or severity of methemoglobinemia can be increased when Fenretinide is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Fenretinide is combined with Etrasimod.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18066548
    Formelli F, Cavadini E, Luksch R, Garaventa A, Villani MG, Appierto V, Persiani S: Pharmacokinetics of oral fenretinide in neuroblastoma patients: indications for optimal dose and dosing schedule also with respect to the active metabolite 4-oxo-fenretinide. Cancer Chemother Pharmacol. 2008 Sep;62(4):655-65. Epub 2007 Dec 8.
  • PMID: 17955489
    Takahashi N, Watanabe Y, Maitani Y, Yamauchi T, Higashiyama K, Ohba T: p-Dodecylaminophenol derived from the synthetic retinoid, fenretinide: antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action. Int J Cancer. 2008 Feb 1;122(3):689-98.
  • PMID: 15197471
    Simeone AM, Tari AM: How retinoids regulate breast cancer cell proliferation and apoptosis. Cell Mol Life Sci. 2004 Jun;61(12):1475-84.

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