Ingenol mebutate

DB05013

small molecule approved

Deskripsi

Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato®. Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions including warts and cancer. PEP005 also has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.

Struktur Molekul 2D

Berat 430.541

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) There is no half-life quantity since ingenol mebutate is a topical treatment.

Volume Distribusi There is no volume of distribution quantity since ingenol mebutate is a topical treatment.

Klirens (Clearance) There is no clearance quantity since ingenol mebutate is a topical treatment.

Absorpsi

Since ingenol mebutate is a topical treatment, the systemic absorption is less than 0.1 ng/mL.

Metabolisme

There is no metabolism of Picato since ingenol mebutate is a topical treatment, and ingenol mebutate does not inhibit or induce a majority of the cytochrome P450 (CYP) enzymes.

Rute Eliminasi

There is no route of elimination since ingenol mebutate is a topical treatment.

Interaksi Makanan

1 Data

1. Take with or without food.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Protein kinase C delta type PRKCD

Protein kinase C alpha type PRKCA

Referensi & Sumber

Synthesis reference: Ogbourne SM, Suhrbier A, Jones B, Cozzi SJ, Boyle GM, Morris M, McAlpine D, Johns J, Scott TM, Sutherland KP, Gardner JM, Le TT, Lenarczyk A, Aylward JH, Parsons PG: Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death. Cancer Res. 2004 Apr 15;64(8):2833-9.

Contoh Produk & Brand

Produk: 6 • International brands: 1

Produk

Picato

Gel • 150 micrograms/g • Cutaneous • EU
Picato

Gel • 0.015 % • Topical • Canada • Approved
Picato

Gel • 500 micrograms/g • Cutaneous • EU
Picato

Gel • 0.05 % • Topical • Canada • Approved
Picato

Gel • 150 ug/1g • Topical • US • Approved
Picato

Gel • 500 ug/1g • Topical • US • Approved

International Brands

Picato gel — LEO Pharma

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan