Banoxantrone

DB04975

small molecule investigational

Deskripsi

Banoxantrone is a highly selective bioreductive drug that is activated in, and is preferentially toxic to, hypoxic cells in tumours. It has been shown to work synergistically with fractionated radiation to significantly delay growth of tumours compared to administration of either banoxantrone or radiation alone. Banoxantrone was also efficacious in tumour models when administered in combination with either cisplatin or chemoradiation. A3115

Struktur Molekul 2D

Berat 444.488
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 0.64 to 0.83 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

AQ4N is selectively and irreversibly converted to AQ4, its cytotoxic form, in hypoxic tumor cells, which are its targeted site of action.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

269 Data
Pitolisant The serum concentration of Banoxantrone can be decreased when it is combined with Pitolisant.
Metreleptin The metabolism of Banoxantrone can be increased when combined with Metreleptin.
Ticlopidine The metabolism of Banoxantrone can be decreased when combined with Ticlopidine.
Raloxifene The metabolism of Banoxantrone can be decreased when combined with Raloxifene.
Memantine The metabolism of Banoxantrone can be decreased when combined with Memantine.
Orphenadrine The metabolism of Banoxantrone can be decreased when combined with Orphenadrine.
Rilpivirine The metabolism of Banoxantrone can be decreased when combined with Rilpivirine.
Clopidogrel The metabolism of Banoxantrone can be decreased when combined with Clopidogrel.
Thiotepa The metabolism of Banoxantrone can be decreased when combined with Thiotepa.
Manidipine The metabolism of Banoxantrone can be decreased when combined with Manidipine.
Piperaquine The metabolism of Banoxantrone can be decreased when combined with Piperaquine.
Nevirapine The metabolism of Banoxantrone can be increased when combined with Nevirapine.
Phenytoin The metabolism of Banoxantrone can be increased when combined with Phenytoin.
Phenobarbital The metabolism of Banoxantrone can be increased when combined with Phenobarbital.
Fosphenytoin The metabolism of Banoxantrone can be increased when combined with Fosphenytoin.
Rifabutin The metabolism of Banoxantrone can be increased when combined with Rifabutin.
Nicotine The metabolism of Banoxantrone can be decreased when combined with Nicotine.
Tramadol The metabolism of Banoxantrone can be decreased when combined with Tramadol.
Valproic acid The metabolism of Banoxantrone can be decreased when combined with Valproic acid.
Methadone The metabolism of Banoxantrone can be decreased when combined with Methadone.
Clobazam The metabolism of Banoxantrone can be decreased when combined with Clobazam.
Mexiletine The metabolism of Banoxantrone can be decreased when combined with Mexiletine.
Fluoxetine The metabolism of Banoxantrone can be decreased when combined with Fluoxetine.
Mephenytoin The metabolism of Banoxantrone can be decreased when combined with Mephenytoin.
Cinnarizine The metabolism of Banoxantrone can be decreased when combined with Cinnarizine.
Diclofenac The metabolism of Banoxantrone can be decreased when combined with Diclofenac.
Verapamil The metabolism of Banoxantrone can be decreased when combined with Verapamil.
Isoflurane The metabolism of Banoxantrone can be decreased when combined with Isoflurane.
Irinotecan The metabolism of Banoxantrone can be decreased when combined with Irinotecan.
Propofol The metabolism of Banoxantrone can be decreased when combined with Propofol.
Brompheniramine The metabolism of Banoxantrone can be decreased when combined with Brompheniramine.
Methylphenobarbital The metabolism of Banoxantrone can be decreased when combined with Methylphenobarbital.
Benzphetamine The metabolism of Banoxantrone can be decreased when combined with Benzphetamine.
Methoxyflurane The metabolism of Banoxantrone can be decreased when combined with Methoxyflurane.
Selegiline The metabolism of Banoxantrone can be decreased when combined with Selegiline.
Promethazine The metabolism of Banoxantrone can be decreased when combined with Promethazine.
Perhexiline The metabolism of Banoxantrone can be decreased when combined with Perhexiline.
Bupropion The metabolism of Banoxantrone can be decreased when combined with Bupropion.
Halothane The metabolism of Banoxantrone can be decreased when combined with Halothane.
Domperidone The metabolism of Banoxantrone can be decreased when combined with Domperidone.
Ketamine The metabolism of Banoxantrone can be decreased when combined with Ketamine.
Sevoflurane The metabolism of Banoxantrone can be decreased when combined with Sevoflurane.
Antipyrine The metabolism of Banoxantrone can be decreased when combined with Antipyrine.
Ethylmorphine The metabolism of Banoxantrone can be decreased when combined with Ethylmorphine.
Flunitrazepam The metabolism of Banoxantrone can be decreased when combined with Flunitrazepam.
Clotiazepam The metabolism of Banoxantrone can be decreased when combined with Clotiazepam.
Lorcaserin The metabolism of Banoxantrone can be decreased when combined with Lorcaserin.
Ospemifene The metabolism of Banoxantrone can be decreased when combined with Ospemifene.
Brivaracetam The metabolism of Brivaracetam can be decreased when combined with Banoxantrone.
Mianserin The metabolism of Mianserin can be decreased when combined with Banoxantrone.
Romidepsin The metabolism of Romidepsin can be decreased when combined with Banoxantrone.
Prasugrel The metabolism of Prasugrel can be decreased when combined with Banoxantrone.
Clomethiazole The metabolism of Clomethiazole can be decreased when combined with Banoxantrone.
Artemether The metabolism of Artemether can be decreased when combined with Banoxantrone.
Methyltestosterone The metabolism of Methyltestosterone can be decreased when combined with Banoxantrone.
Ketobemidone The metabolism of Ketobemidone can be decreased when combined with Banoxantrone.
Seratrodast The metabolism of Seratrodast can be decreased when combined with Banoxantrone.
Perampanel The metabolism of Perampanel can be decreased when combined with Banoxantrone.
Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Banoxantrone.
Asunaprevir The metabolism of Asunaprevir can be decreased when combined with Banoxantrone.
Velpatasvir The metabolism of Velpatasvir can be decreased when combined with Banoxantrone.
Artemisinin The metabolism of Artemisinin can be decreased when combined with Banoxantrone.
Testosterone cypionate The metabolism of Testosterone cypionate can be decreased when combined with Banoxantrone.
Testosterone enanthate The metabolism of Testosterone enanthate can be decreased when combined with Banoxantrone.
Hydrocodone The metabolism of Banoxantrone can be decreased when combined with Hydrocodone.
Istradefylline The metabolism of Istradefylline can be decreased when combined with Banoxantrone.
Cisapride The metabolism of Banoxantrone can be decreased when combined with Cisapride.
Voxelotor The metabolism of Voxelotor can be decreased when combined with Banoxantrone.
Amitriptyline The metabolism of Banoxantrone can be decreased when combined with Amitriptyline.
Imipramine The metabolism of Banoxantrone can be decreased when combined with Imipramine.
Osilodrostat The metabolism of Osilodrostat can be decreased when combined with Banoxantrone.
Esketamine The metabolism of Esketamine can be decreased when combined with Banoxantrone.
Meperidine The metabolism of Banoxantrone can be decreased when combined with Meperidine.
Apomorphine The metabolism of Banoxantrone can be decreased when combined with Apomorphine.
Epinastine The metabolism of Banoxantrone can be decreased when combined with Epinastine.
Norgestimate The metabolism of Banoxantrone can be decreased when combined with Norgestimate.
Fenfluramine The metabolism of Banoxantrone can be decreased when combined with Fenfluramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Banoxantrone is combined with Benzocaine.
Cyclophosphamide The metabolism of Cyclophosphamide can be decreased when combined with Banoxantrone.
Ifosfamide The metabolism of Ifosfamide can be decreased when combined with Banoxantrone.
Enasidenib The metabolism of Enasidenib can be decreased when combined with Banoxantrone.
Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Banoxantrone.
Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Banoxantrone.
Cisplatin The metabolism of Banoxantrone can be decreased when combined with Cisplatin.
Ethanol The metabolism of Banoxantrone can be decreased when combined with Ethanol.
Miconazole The metabolism of Banoxantrone can be decreased when combined with Miconazole.
Phencyclidine The metabolism of Banoxantrone can be decreased when combined with Phencyclidine.
Sulfaphenazole The metabolism of Banoxantrone can be decreased when combined with Sulfaphenazole.
Triclabendazole The metabolism of Banoxantrone can be decreased when combined with Triclabendazole.
Fluvoxamine The metabolism of Banoxantrone can be decreased when combined with Fluvoxamine.
Paroxetine The metabolism of Banoxantrone can be decreased when combined with Paroxetine.
Curcumin sulfate The metabolism of Banoxantrone can be decreased when combined with Curcumin sulfate.
Sertraline The metabolism of Banoxantrone can be decreased when combined with Sertraline.
Methylene blue The metabolism of Banoxantrone can be decreased when combined with Methylene blue.
Desipramine The metabolism of Banoxantrone can be decreased when combined with Desipramine.
Armodafinil The metabolism of Banoxantrone can be increased when combined with Armodafinil.
Troglitazone The metabolism of Banoxantrone can be increased when combined with Troglitazone.
Cerivastatin The metabolism of Banoxantrone can be increased when combined with Cerivastatin.
Simvastatin The metabolism of Banoxantrone can be increased when combined with Simvastatin.
Fluvastatin The metabolism of Banoxantrone can be increased when combined with Fluvastatin.

Target Protein

DNA topoisomerase 2-beta TOP2B
DNA topoisomerase 2-alpha TOP2A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17482438
    McKeown SR, Cowen RL, Williams KJ: Bioreductive drugs: from concept to clinic. Clin Oncol (R Coll Radiol). 2007 Aug;19(6):427-42. Epub 2007 May 4.
  • PMID: 15712360
    McErlane V, Yakkundi A, McCarthy HO, Hughes CM, Patterson LH, Hirst DG, Robson T, McKeown SR: A cytochrome P450 2B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N. J Gene Med. 2005 Jul;7(7):851-9.
  • PMID: 17340571
    Atkinson SJ, Loadman PM, Sutton C, Patterson LH, Clench MR: Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(7):1271-6.
  • PMID: 17404106
    Lalani AS, Alters SE, Wong A, Albertella MR, Cleland JL, Henner WD: Selective tumor targeting by the hypoxia-activated prodrug AQ4N blocks tumor growth and metastasis in preclinical models of pancreatic cancer. Clin Cancer Res. 2007 Apr 1;13(7):2216-25.
  • PMID: 10864207
    Patterson LH, McKeown SR, Ruparelia K, Double JA, Bibby MC, Cole S, Stratford IJ: Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent. Br J Cancer. 2000 Jun;82(12):1984-90.
  • PMID: 11259326
    Loadman PM, Swaine DJ, Bibby MC, Welham KJ, Patterson LH: A preclinical pharmacokinetic study of the bioreductive drug AQ4N. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):422-6.

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Sekuens Gen/Protein (FASTA)

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