Troxacitabine

DB04961

small molecule investigational

Deskripsi

Troxacitabine is a nucleoside analog with antineoplastic activity. There has been growing interest in its development for the treatment of patients with refractory lymphoproliferative conditions.

Struktur Molekul 2D

Berat 213.1906
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

39 Data
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Troxacitabine.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Troxacitabine.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Troxacitabine.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Troxacitabine.
Lidocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Troxacitabine.
Ambroxol The risk or severity of methemoglobinemia can be increased when Troxacitabine is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Troxacitabine is combined with Etrasimod.

Target Protein

DNA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16609029
    Lee CK, Rowinsky EK, Li J, Giles F, Moore MJ, Hidalgo M, Capparelli E, Jolivet J, Baker SD: Population pharmacokinetics of troxacitabine, a novel dioxolane nucleoside analogue. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2158-65.
  • PMID: 17371201
    Quintas-Cardama A, Cortes J: Evaluation of the L-stereoisomeric nucleoside analog troxacitabine for the treatment of acute myeloid leukemia. Expert Opin Investig Drugs. 2007 Apr;16(4):547-57.
  • PMID: 17558697
    Swords R, Giles F: Troxacitabine in acute leukemia. Hematology. 2007 Jun;12(3):219-27.
  • PMID: 15009060
    Orsolic N, Giles FJ, Gourdeau H, Golemovic M, Beran M, Cortes J, Freireich EJ, Kantarjian H, Verstovsek S: Troxacitabine and imatinib mesylate combination therapy of chronic myeloid leukaemia: preclinical evaluation. Br J Haematol. 2004 Mar;124(6):727-38.
  • PMID: 15069761
    Boivin AJ, Gourdeau H, Momparler RL: Action of troxacitabine on cells transduced with human cytidine deaminase cDNA. Cancer Invest. 2004;22(1):25-9.
  • PMID: 15266019
    Kim TE, Park SY, Hsu CH, Dutschman GE, Cheng YC: Synergistic antitumor activity of troxacitabine and camptothecin in selected human cancer cell lines. Mol Pharmacol. 2004 Aug;66(2):285-92.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
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Sekuens Gen/Protein (FASTA)

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