Tipifarnib

DB04960

small molecule investigational

Deskripsi

Tipifarnib (R-115777) is a substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors. It is also called Zarnestra. In June 2005, the FDA issued a Not Approvable Letter for Zarnestra.

Struktur Molekul 2D

Berat 489.396
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

39 Data
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tipifarnib.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Tipifarnib.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Tipifarnib.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Tipifarnib.
Lidocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Tipifarnib.
Ambroxol The risk or severity of methemoglobinemia can be increased when Tipifarnib is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Tipifarnib is combined with Etrasimod.

Target Protein

Farnesyl pyrophosphate synthase FDPS
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA
Protein farnesyltransferase subunit beta FNTB

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17876043
    Martin LA, Head JE, Pancholi S, Salter J, Quinn E, Detre S, Kaye S, Howes A, Dowsett M, Johnston SR: The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo. Mol Cancer Ther. 2007 Sep;6(9):2458-67.
  • PMID: 16818651
    Wang CC, Liao YP, Mischel PS, Iwamoto KS, Cacalano NA, McBride WH: HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway. Cancer Res. 2006 Jul 1;66(13):6756-62.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Zarnestra

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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