Rifalazil

DB04934

small molecule investigational

Deskripsi

Rifalazil is a derivative of the antibiotic rifamycin. It is being investigated by ActivBiotics for the treatment of various bacterial infections.

Struktur Molekul 2D

Berat 941.088
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

The major metabolites of rifalazil in human are 25-deacetyl-benzoxazinorifamycin and 32-hydroxy-benzoxazinorifamycin. The enzyme responsible for the benzoxazinorifamycin-25-deacetylation is a B-esterase while the enzyme responsible for the benzoxazinorifamycin-32-hydroxylation is CYP3A4.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

161 Data
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifalazil.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Rifalazil.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Rifalazil.
Pitolisant The serum concentration of Rifalazil can be decreased when it is combined with Pitolisant.
Metreleptin The metabolism of Rifalazil can be increased when combined with Metreleptin.
Dicoumarol The risk or severity of bleeding can be increased when Rifalazil is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Rifalazil is combined with Phenindione.
Coumarin The risk or severity of bleeding can be increased when Rifalazil is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Rifalazil is combined with (R)-warfarin.
Tioclomarol The risk or severity of bleeding can be increased when Rifalazil is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Rifalazil is combined with (S)-Warfarin.
Warfarin The risk or severity of bleeding can be increased when Rifalazil is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Rifalazil is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Rifalazil is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Rifalazil is combined with 4-hydroxycoumarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Rifalazil is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Rifalazil is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Rifalazil is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Rifalazil is combined with Diphenadione.
Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Rifalazil.
Cenobamate The serum concentration of Rifalazil can be decreased when it is combined with Cenobamate.
Ritonavir The serum concentration of Rifalazil can be increased when it is combined with Ritonavir.
Haloperidol The serum concentration of Haloperidol can be increased when it is combined with Rifalazil.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Rifalazil.
Tucatinib The metabolism of Tucatinib can be decreased when combined with Rifalazil.
Abametapir The serum concentration of Rifalazil can be increased when it is combined with Abametapir.
Satralizumab The serum concentration of Rifalazil can be decreased when it is combined with Satralizumab.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Rifalazil.
Sotorasib The serum concentration of Rifalazil can be decreased when it is combined with Sotorasib.
Cyclosporine The metabolism of Rifalazil can be decreased when combined with Cyclosporine.
Fluvoxamine The metabolism of Rifalazil can be decreased when combined with Fluvoxamine.
Fluconazole The metabolism of Rifalazil can be decreased when combined with Fluconazole.
Erythromycin The serum concentration of Rifalazil can be increased when it is combined with Erythromycin.
Ziprasidone The metabolism of Rifalazil can be decreased when combined with Ziprasidone.
Isradipine The metabolism of Rifalazil can be decreased when combined with Isradipine.
Diltiazem The metabolism of Rifalazil can be decreased when combined with Diltiazem.
Clozapine The metabolism of Rifalazil can be decreased when combined with Clozapine.
Ciprofloxacin The metabolism of Rifalazil can be decreased when combined with Ciprofloxacin.
Nicardipine The metabolism of Rifalazil can be decreased when combined with Nicardipine.
Verapamil The metabolism of Rifalazil can be decreased when combined with Verapamil.
Aprepitant The metabolism of Rifalazil can be decreased when combined with Aprepitant.
Isoniazid The metabolism of Rifalazil can be decreased when combined with Isoniazid.
Primaquine The metabolism of Rifalazil can be decreased when combined with Primaquine.
Miconazole The metabolism of Rifalazil can be decreased when combined with Miconazole.
Fusidic acid The metabolism of Rifalazil can be decreased when combined with Fusidic acid.
Zimelidine The metabolism of Rifalazil can be decreased when combined with Zimelidine.
Dronedarone The metabolism of Rifalazil can be decreased when combined with Dronedarone.
Milnacipran The metabolism of Rifalazil can be decreased when combined with Milnacipran.
Simeprevir The metabolism of Rifalazil can be decreased when combined with Simeprevir.
Isavuconazonium The metabolism of Rifalazil can be decreased when combined with Isavuconazonium.
Desvenlafaxine The metabolism of Rifalazil can be decreased when combined with Desvenlafaxine.
Nilvadipine The metabolism of Rifalazil can be decreased when combined with Nilvadipine.
Seproxetine The metabolism of Rifalazil can be decreased when combined with Seproxetine.
Linagliptin The metabolism of Rifalazil can be decreased when combined with Linagliptin.
Indalpine The metabolism of Rifalazil can be decreased when combined with Indalpine.
Netupitant The metabolism of Rifalazil can be decreased when combined with Netupitant.
Barnidipine The metabolism of Rifalazil can be decreased when combined with Barnidipine.
Benidipine The metabolism of Rifalazil can be decreased when combined with Benidipine.
Venetoclax The metabolism of Rifalazil can be decreased when combined with Venetoclax.
Isavuconazole The metabolism of Rifalazil can be decreased when combined with Isavuconazole.
Fosnetupitant The metabolism of Rifalazil can be decreased when combined with Fosnetupitant.
Berotralstat The metabolism of Rifalazil can be decreased when combined with Berotralstat.
Midostaurin The metabolism of Rifalazil can be decreased when combined with Midostaurin.
Voriconazole The metabolism of Rifalazil can be decreased when combined with Voriconazole.
Danazol The metabolism of Rifalazil can be decreased when combined with Danazol.
Nelfinavir The metabolism of Rifalazil can be decreased when combined with Nelfinavir.
Indinavir The metabolism of Rifalazil can be decreased when combined with Indinavir.
Terfenadine The metabolism of Rifalazil can be decreased when combined with Terfenadine.
Efavirenz The metabolism of Rifalazil can be decreased when combined with Efavirenz.
Ergotamine The metabolism of Rifalazil can be decreased when combined with Ergotamine.
Amprenavir The metabolism of Rifalazil can be decreased when combined with Amprenavir.
Delavirdine The metabolism of Rifalazil can be decreased when combined with Delavirdine.
Methimazole The metabolism of Rifalazil can be decreased when combined with Methimazole.
Conivaptan The metabolism of Rifalazil can be decreased when combined with Conivaptan.
Tipranavir The metabolism of Rifalazil can be decreased when combined with Tipranavir.
Telithromycin The metabolism of Rifalazil can be decreased when combined with Telithromycin.
Ketoconazole The metabolism of Rifalazil can be decreased when combined with Ketoconazole.
Atazanavir The metabolism of Rifalazil can be decreased when combined with Atazanavir.
Amiodarone The metabolism of Rifalazil can be decreased when combined with Amiodarone.
Nefazodone The metabolism of Rifalazil can be decreased when combined with Nefazodone.
Itraconazole The metabolism of Rifalazil can be decreased when combined with Itraconazole.
Clarithromycin The metabolism of Rifalazil can be decreased when combined with Clarithromycin.
Saquinavir The metabolism of Rifalazil can be decreased when combined with Saquinavir.
Posaconazole The metabolism of Rifalazil can be decreased when combined with Posaconazole.
Darunavir The metabolism of Rifalazil can be decreased when combined with Darunavir.
Lopinavir The metabolism of Rifalazil can be decreased when combined with Lopinavir.
Ditiocarb The metabolism of Rifalazil can be decreased when combined with Ditiocarb.
Nilotinib The metabolism of Rifalazil can be decreased when combined with Nilotinib.
Telaprevir The metabolism of Rifalazil can be decreased when combined with Telaprevir.
Lonafarnib The metabolism of Rifalazil can be decreased when combined with Lonafarnib.
Boceprevir The metabolism of Rifalazil can be decreased when combined with Boceprevir.
Elvitegravir The metabolism of Rifalazil can be decreased when combined with Elvitegravir.
Stiripentol The metabolism of Rifalazil can be decreased when combined with Stiripentol.
Ribociclib The metabolism of Rifalazil can be decreased when combined with Ribociclib.
Danoprevir The metabolism of Rifalazil can be decreased when combined with Danoprevir.
Troleandomycin The metabolism of Rifalazil can be decreased when combined with Troleandomycin.
Phenytoin The metabolism of Rifalazil can be increased when combined with Phenytoin.
Pentobarbital The metabolism of Rifalazil can be increased when combined with Pentobarbital.
Carbamazepine The metabolism of Rifalazil can be increased when combined with Carbamazepine.
Mitotane The metabolism of Rifalazil can be increased when combined with Mitotane.

Target Protein

DNA-directed RNA polymerase subunit beta rpoB

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10923859
    Mae T, Inaba T, Konishi E, Hosoe K, Hidaka T: Identification of enzymes responsible for rifalazil metabolism in human liver microsomes. Xenobiotica. 2000 Jun;30(6):565-74.
  • PMID: 12556219
    Rothstein DM, Hartman AD, Cynamon MH, Eisenstein BI: Development potential of rifalazil. Expert Opin Investig Drugs. 2003 Feb;12(2):255-71.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Rifalazil

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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