Peringatan Keamanan

No data are available with respect to overdosage in humans. The expected reaction would be excessive hypotension, which should be treated with drug discontinuation or reduction and appropriate measures.

Nesiritide

DB04899

biotech approved investigational

Deskripsi

Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 18 minutes
Volume Distribusi * 0.19 L/kg
Klirens (Clearance) * 9.2 mL/min/k [patients with congestive heart failure receiving IV infusion]

Absorpsi

Administration of nesiritide exhibits biphasic disposition from the plasma.

Metabolisme

Nesiritide undergoes proteolytic cleavage of the peptide by endopeptidases, such as neutral endopeptidase, which are present on the vascular lumenal surface.

Rute Eliminasi

Human BNP is cleared from the circulation via the following three independent mechanisms, in order of decreasing importance: 1) binding to cell surface clearance receptors with subsequent cellular internalization and lysosomal proteolysis; 2) proteolytic cleavage of the peptide by endopeptidases, such as neutral endopeptidase, which are present on the vascular lumenal surface; and 3) renal filtration.

Interaksi Obat

304 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Nesiritide is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Nesiritide is combined with Levodopa.
Risperidone Nesiritide may increase the hypotensive activities of Risperidone.
Aripiprazole Aripiprazole may increase the hypotensive activities of Nesiritide.
Aripiprazole lauroxil Aripiprazole lauroxil may increase the hypotensive activities of Nesiritide.
Nicorandil Nicorandil may increase the hypotensive activities of Nesiritide.
Linezolid Linezolid may increase the orthostatic hypotensive activities of Nesiritide.
Furazolidone Furazolidone may increase the orthostatic hypotensive activities of Nesiritide.
Procaine Procaine may increase the orthostatic hypotensive activities of Nesiritide.
Tranylcypromine Tranylcypromine may increase the orthostatic hypotensive activities of Nesiritide.
Phenelzine Phenelzine may increase the orthostatic hypotensive activities of Nesiritide.
Minaprine Minaprine may increase the orthostatic hypotensive activities of Nesiritide.
Selegiline Selegiline may increase the orthostatic hypotensive activities of Nesiritide.
Procarbazine Procarbazine may increase the orthostatic hypotensive activities of Nesiritide.
Moclobemide Moclobemide may increase the orthostatic hypotensive activities of Nesiritide.
Isocarboxazid Isocarboxazid may increase the orthostatic hypotensive activities of Nesiritide.
Rasagiline Rasagiline may increase the orthostatic hypotensive activities of Nesiritide.
Pargyline Pargyline may increase the orthostatic hypotensive activities of Nesiritide.
Clorgiline Clorgiline may increase the orthostatic hypotensive activities of Nesiritide.
Iproniazid Iproniazid may increase the orthostatic hypotensive activities of Nesiritide.
Nialamide Nialamide may increase the orthostatic hypotensive activities of Nesiritide.
Safinamide Safinamide may increase the orthostatic hypotensive activities of Nesiritide.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the orthostatic hypotensive activities of Nesiritide.
Methylene blue Methylene blue may increase the orthostatic hypotensive activities of Nesiritide.
Hydracarbazine Hydracarbazine may increase the orthostatic hypotensive activities of Nesiritide.
Pirlindole Pirlindole may increase the orthostatic hypotensive activities of Nesiritide.
Toloxatone Toloxatone may increase the orthostatic hypotensive activities of Nesiritide.
Benmoxin Benmoxin may increase the orthostatic hypotensive activities of Nesiritide.
Mebanazine Mebanazine may increase the orthostatic hypotensive activities of Nesiritide.
Octamoxin Octamoxin may increase the orthostatic hypotensive activities of Nesiritide.
Pheniprazine Pheniprazine may increase the orthostatic hypotensive activities of Nesiritide.
Phenoxypropazine Phenoxypropazine may increase the orthostatic hypotensive activities of Nesiritide.
Pivhydrazine Pivhydrazine may increase the orthostatic hypotensive activities of Nesiritide.
Safrazine Safrazine may increase the orthostatic hypotensive activities of Nesiritide.
Caroxazone Caroxazone may increase the orthostatic hypotensive activities of Nesiritide.
Harmaline Harmaline may increase the orthostatic hypotensive activities of Nesiritide.
Brofaromine Brofaromine may increase the orthostatic hypotensive activities of Nesiritide.
Butalbital Butalbital may increase the hypotensive activities of Nesiritide.
Pentobarbital Pentobarbital may increase the hypotensive activities of Nesiritide.
Secobarbital Secobarbital may increase the hypotensive activities of Nesiritide.
Methohexital Methohexital may increase the hypotensive activities of Nesiritide.
Thiopental Thiopental may increase the hypotensive activities of Nesiritide.
Primidone Primidone may increase the hypotensive activities of Nesiritide.
Methylphenobarbital Methylphenobarbital may increase the hypotensive activities of Nesiritide.
Thiamylal Thiamylal may increase the hypotensive activities of Nesiritide.
Phenobarbital Phenobarbital may increase the hypotensive activities of Nesiritide.
Amobarbital Amobarbital may increase the hypotensive activities of Nesiritide.
Hexobarbital Hexobarbital may increase the hypotensive activities of Nesiritide.
Barbital Barbital may increase the hypotensive activities of Nesiritide.
Barbexaclone Barbexaclone may increase the hypotensive activities of Nesiritide.
Butabarbital Butabarbital may increase the hypotensive activities of Nesiritide.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Nesiritide.
Streptokinase The risk or severity of adverse effects can be increased when Streptokinase is combined with Nesiritide.
Methyclothiazide The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Nesiritide.
Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Nesiritide.
Morphine The risk or severity of adverse effects can be increased when Morphine is combined with Nesiritide.
Ropivacaine The risk or severity of adverse effects can be increased when Ropivacaine is combined with Nesiritide.
Bupivacaine The risk or severity of adverse effects can be increased when Bupivacaine is combined with Nesiritide.
Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Nesiritide.
Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Nesiritide.
Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Nesiritide.
Triamterene The risk or severity of adverse effects can be increased when Triamterene is combined with Nesiritide.
Pramipexole The risk or severity of adverse effects can be increased when Pramipexole is combined with Nesiritide.
Spironolactone The risk or severity of adverse effects can be increased when Spironolactone is combined with Nesiritide.
Nitric Oxide The risk or severity of adverse effects can be increased when Nitric Oxide is combined with Nesiritide.
Imipramine The risk or severity of adverse effects can be increased when Imipramine is combined with Nesiritide.
Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Nesiritide.
Nabilone The risk or severity of adverse effects can be increased when Nabilone is combined with Nesiritide.
Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Nesiritide.
Amiloride The risk or severity of adverse effects can be increased when Amiloride is combined with Nesiritide.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Nesiritide.
Dexmedetomidine The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Nesiritide.
Verapamil The risk or severity of adverse effects can be increased when Verapamil is combined with Nesiritide.
Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Nesiritide.
Amphotericin B The risk or severity of adverse effects can be increased when Amphotericin B is combined with Nesiritide.
Furosemide The risk or severity of adverse effects can be increased when Furosemide is combined with Nesiritide.
Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Nesiritide.
Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Nesiritide.
Tamsulosin The risk or severity of adverse effects can be increased when Tamsulosin is combined with Nesiritide.
Sufentanil The risk or severity of adverse effects can be increased when Sufentanil is combined with Nesiritide.
Apomorphine The risk or severity of adverse effects can be increased when Apomorphine is combined with Nesiritide.
Mannitol The risk or severity of adverse effects can be increased when Mannitol is combined with Nesiritide.
Isoflurane The risk or severity of adverse effects can be increased when Isoflurane is combined with Nesiritide.
Propofol The risk or severity of adverse effects can be increased when Propofol is combined with Nesiritide.
Conivaptan The risk or severity of adverse effects can be increased when Conivaptan is combined with Nesiritide.
Isosorbide dinitrate The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Nesiritide.
Bumetanide The risk or severity of adverse effects can be increased when Bumetanide is combined with Nesiritide.
Remifentanil The risk or severity of adverse effects can be increased when Remifentanil is combined with Nesiritide.
Etacrynic acid The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Nesiritide.
Levosimendan The risk or severity of adverse effects can be increased when Levosimendan is combined with Nesiritide.
Dipyridamole The risk or severity of adverse effects can be increased when Dipyridamole is combined with Nesiritide.
Levobupivacaine The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Nesiritide.
Isosorbide mononitrate The risk or severity of adverse effects can be increased when Isosorbide mononitrate is combined with Nesiritide.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Nesiritide.
Iloprost The risk or severity of adverse effects can be increased when Iloprost is combined with Nesiritide.
Papaverine The risk or severity of adverse effects can be increased when Papaverine is combined with Nesiritide.
Nifedipine The risk or severity of adverse effects can be increased when Nifedipine is combined with Nesiritide.
Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Nesiritide.
Amifostine The risk or severity of adverse effects can be increased when Amifostine is combined with Nesiritide.
Diclofenamide The risk or severity of adverse effects can be increased when Diclofenamide is combined with Nesiritide.

Target Protein

Atrial natriuretic peptide receptor 1 NPR1
Atrial natriuretic peptide receptor 2 NPR2
Atrial natriuretic peptide receptor 3 NPR3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17826644
    Jefferies JL, Price JF, Denfield SW, Chang AC, Dreyer WJ, McMahon CJ, Grenier MA, Clunie SK, Thomas A, Moffett BS, Wann TS, Smith EO, Towbin JA: Safety and efficacy of nesiritide in pediatric heart failure. J Card Fail. 2007 Sep;13(7):541-8.
  • PMID: 12668889
    Maisel AS: Nesiritide: a new therapy for the treatment of heart failure. Cardiovasc Toxicol. 2003;3(1):37-42.
  • PMID: 12549957
    Vichiendilokkul A, Tran A, Racine E: Nesiritide: a novel approach for acute heart failure. Ann Pharmacother. 2003 Feb;37(2):247-58.
  • PMID: 12028606
    Cheng JW: Nesiritide: review of clinical pharmacology and role in heart failure management. Heart Dis. 2002 May-Jun;4(3):199-203.
  • PMID: 12070532
    Bettencourt P: Brain natriuretic peptide (nesiritide) in the treatment of heart failure. Cardiovasc Drug Rev. 2002 Winter;20(1):27-36.

Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
  • Natrecor
    Injection, powder, lyophilized, for solution • 1.5 mg/5mL • Intravenous • US • Approved
  • Natrecor
    Powder, for solution • 1.5 mg / vial • Intravenous • Canada • Approved

Sekuens Gen/Protein (FASTA)

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