Most common adverse reactions associated with the use of lucinactant are endotracheal tube reflux, pallor, endotracheal tube obstruction, and need for
dose interruption.
Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). More specifically, it mimics the C-terminal amphipathic helical domain of this protein. It also consists of phospholipids (dipalmitoylphosphatidylcholine, DPPC and palmitoyloleoyl phosphatidylglycerol, POPG) and a fatty acid (palmitic acid). It is completely devoid of animal-derived components. FDA approved on March 6, 2012.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ceritinib | Lucinactant may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Lucinactant may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Lucinactant. |
| Esmolol | Esmolol may increase the bradycardic activities of Lucinactant. |
| Betaxolol | Betaxolol may increase the bradycardic activities of Lucinactant. |
| Midodrine | Midodrine may increase the bradycardic activities of Lucinactant. |
| Pregabalin | Pregabalin may increase the bradycardic activities of Lucinactant. |
| Metoprolol | Metoprolol may increase the bradycardic activities of Lucinactant. |
| Isradipine | Isradipine may increase the bradycardic activities of Lucinactant. |
| Atenolol | Atenolol may increase the bradycardic activities of Lucinactant. |
| Diltiazem | Diltiazem may increase the bradycardic activities of Lucinactant. |
| Trimethadione | Trimethadione may increase the bradycardic activities of Lucinactant. |
| Timolol | Timolol may increase the bradycardic activities of Lucinactant. |
| Amlodipine | Amlodipine may increase the bradycardic activities of Lucinactant. |
| Digoxin | Digoxin may increase the bradycardic activities of Lucinactant. |
| Nimodipine | Nimodipine may increase the bradycardic activities of Lucinactant. |
| Nisoldipine | Nisoldipine may increase the bradycardic activities of Lucinactant. |
| Bendroflumethiazide | Bendroflumethiazide may increase the bradycardic activities of Lucinactant. |
| Sotalol | Sotalol may increase the bradycardic activities of Lucinactant. |
| Lercanidipine | Lercanidipine may increase the bradycardic activities of Lucinactant. |
| Lamotrigine | Lamotrigine may increase the bradycardic activities of Lucinactant. |
| Cinnarizine | Cinnarizine may increase the bradycardic activities of Lucinactant. |
| Propranolol | Propranolol may increase the bradycardic activities of Lucinactant. |
| Clonidine | Clonidine may increase the bradycardic activities of Lucinactant. |
| Ethosuximide | Ethosuximide may increase the bradycardic activities of Lucinactant. |
| Labetalol | Labetalol may increase the bradycardic activities of Lucinactant. |
| Bisoprolol | Bisoprolol may increase the bradycardic activities of Lucinactant. |
| Nicardipine | Nicardipine may increase the bradycardic activities of Lucinactant. |
| Dexmedetomidine | Dexmedetomidine may increase the bradycardic activities of Lucinactant. |
| Magnesium sulfate | Magnesium sulfate may increase the bradycardic activities of Lucinactant. |
| Verapamil | Verapamil may increase the bradycardic activities of Lucinactant. |
| Galantamine | Galantamine may increase the bradycardic activities of Lucinactant. |
| Tizanidine | Tizanidine may increase the bradycardic activities of Lucinactant. |
| Sufentanil | Sufentanil may increase the bradycardic activities of Lucinactant. |
| Alfentanil | Alfentanil may increase the bradycardic activities of Lucinactant. |
| Fentanyl | Fentanyl may increase the bradycardic activities of Lucinactant. |
| Levomenthol | Levomenthol may increase the bradycardic activities of Lucinactant. |
| Loperamide | Loperamide may increase the bradycardic activities of Lucinactant. |
| Donepezil | Donepezil may increase the bradycardic activities of Lucinactant. |
| Alprenolol | Alprenolol may increase the bradycardic activities of Lucinactant. |
| Remifentanil | Remifentanil may increase the bradycardic activities of Lucinactant. |
| Zonisamide | Zonisamide may increase the bradycardic activities of Lucinactant. |
| Pindolol | Pindolol may increase the bradycardic activities of Lucinactant. |
| Methyldopa | Methyldopa may increase the bradycardic activities of Lucinactant. |
| Rivastigmine | Rivastigmine may increase the bradycardic activities of Lucinactant. |
| Guanfacine | Guanfacine may increase the bradycardic activities of Lucinactant. |
| Felodipine | Felodipine may increase the bradycardic activities of Lucinactant. |
| Nitrendipine | Nitrendipine may increase the bradycardic activities of Lucinactant. |
| Perhexiline | Perhexiline may increase the bradycardic activities of Lucinactant. |
| Nifedipine | Nifedipine may increase the bradycardic activities of Lucinactant. |
| Amiodarone | Amiodarone may increase the bradycardic activities of Lucinactant. |
| Carvedilol | Carvedilol may increase the bradycardic activities of Lucinactant. |
| Bretylium | Bretylium may increase the bradycardic activities of Lucinactant. |
| Propafenone | Propafenone may increase the bradycardic activities of Lucinactant. |
| Acebutolol | Acebutolol may increase the bradycardic activities of Lucinactant. |
| Nadolol | Nadolol may increase the bradycardic activities of Lucinactant. |
| Bepridil | Bepridil may increase the bradycardic activities of Lucinactant. |
| Bevantolol | Bevantolol may increase the bradycardic activities of Lucinactant. |
| Practolol | Practolol may increase the bradycardic activities of Lucinactant. |
| Penbutolol | Penbutolol may increase the bradycardic activities of Lucinactant. |
| Mibefradil | Mibefradil may increase the bradycardic activities of Lucinactant. |
| Oxprenolol | Oxprenolol may increase the bradycardic activities of Lucinactant. |
| Nimesulide | Nimesulide may increase the bradycardic activities of Lucinactant. |
| Prenylamine | Prenylamine may increase the bradycardic activities of Lucinactant. |
| Cyclandelate | Cyclandelate may increase the bradycardic activities of Lucinactant. |
| Flunarizine | Flunarizine may increase the bradycardic activities of Lucinactant. |
| Fluspirilene | Fluspirilene may increase the bradycardic activities of Lucinactant. |
| Celiprolol | Celiprolol may increase the bradycardic activities of Lucinactant. |
| Dronedarone | Dronedarone may increase the bradycardic activities of Lucinactant. |
| Nebivolol | Nebivolol may increase the bradycardic activities of Lucinactant. |
| Clevidipine | Lucinactant may increase the bradycardic activities of Clevidipine. |
| Methsuximide | Lucinactant may increase the bradycardic activities of Methsuximide. |
| Seletracetam | Lucinactant may increase the bradycardic activities of Seletracetam. |
| Nylidrin | Lucinactant may increase the bradycardic activities of Nylidrin. |
| Lacosamide | The risk or severity of ventricular arrhythmias, bradycardia, and heart block can be increased when Lucinactant is combined with Lacosamide. |
| Calfactant | Lucinactant may increase the bradycardic activities of Calfactant. |
| Dotarizine | Lucinactant may increase the bradycardic activities of Dotarizine. |
| Pasireotide | Lucinactant may increase the bradycardic activities of Pasireotide. |
| Nilvadipine | Lucinactant may increase the bradycardic activities of Nilvadipine. |
| Bufuralol | Lucinactant may increase the bradycardic activities of Bufuralol. |
| Beractant | Lucinactant may increase the bradycardic activities of Beractant. |
| Lanreotide | Lucinactant may increase the bradycardic activities of Lanreotide. |
| Tranilast | Lucinactant may increase the bradycardic activities of Tranilast. |
| Bopindolol | Lucinactant may increase the bradycardic activities of Bopindolol. |
| Bupranolol | Lucinactant may increase the bradycardic activities of Bupranolol. |
| Agmatine | Lucinactant may increase the bradycardic activities of Agmatine. |
| Crizotinib | Crizotinib may increase the bradycardic activities of Lucinactant. |
| Fingolimod | Lucinactant may increase the bradycardic activities of Fingolimod. |
| Tofacitinib | Lucinactant may increase the bradycardic activities of Tofacitinib. |
| Regorafenib | Lucinactant may increase the bradycardic activities of Regorafenib. |
| Indenolol | Lucinactant may increase the bradycardic activities of Indenolol. |
| Fendiline | Lucinactant may increase the bradycardic activities of Fendiline. |
| Eperisone | Lucinactant may increase the bradycardic activities of Eperisone. |
| Trimebutine | Lucinactant may increase the bradycardic activities of Trimebutine. |
| Pinaverium | Lucinactant may increase the bradycardic activities of Pinaverium. |
| Poractant alfa | Lucinactant may increase the bradycardic activities of Poractant alfa. |
| Arotinolol | Lucinactant may increase the bradycardic activities of Arotinolol. |
| Tolfenamic acid | Lucinactant may increase the bradycardic activities of Tolfenamic acid. |
| Barnidipine | Lucinactant may increase the bradycardic activities of Barnidipine. |
| Aranidipine | Lucinactant may increase the bradycardic activities of Aranidipine. |