Peringatan Keamanan

It is not known if pegaptanib is safe in pregnant women or if it is excreted in breast milk. Likewise, no studies have been done in the pediatric population. Most adverse events elated to the drug are ocular however non-ocular adverse events related to the drug or the injection procedure also occurred, among which headaches and rhinorrhoea appeared in more than 1% of patients. Pegaptanib is contraindicated when the patient has an ocular or periocular infection.

Pegaptanib

DB04895

biotech approved investigational

Deskripsi

Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability.

Pegaptanib was granted FDA approval on 17 September 2004.L17903

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) In humans, after a 3 mg monocular dose (10 times the recommended dose), the average (± standard deviation) apparent plasma half-life of pegaptanib is 10 (± 4) days.
Volume Distribusi It is distributed into vitreous fluid, retina, aqueous fluid, and kidneys. As well, it has been shown to cross the placenta in mice but whether or not it crosses the placenta in humans is unknown.
Klirens (Clearance) -

Absorpsi

In animals, pegaptanib is slowly absorbed into the systemic circulation from the eye after intravitreous administration.

Metabolisme

Based on preclinical data, pegaptanib is metabolized by endo- and exonucleases.

Rute Eliminasi

It is excreted primarily in urine as unchanged drug and also as metabolites. There is no dosage adjustment required for patients with renal impairment although it must be noted that not many studies have looked at patients with a creatinine clearance of 30mL/min.

Interaksi Obat

760 Data
Peginterferon alfa-2a The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Peginterferon alfa-2a.
Pegfilgrastim The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Pegfilgrastim.
Peginterferon alfa-2b The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Peginterferon alfa-2b.
Pegaspargase The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Pegaspargase.
Pegademase The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Pegademase.
Pegvisomant The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Pegvisomant.
Propylene glycol The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Propylene glycol.
Heptaethylene glycol The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Heptaethylene glycol.
Egaptivon pegol The therapeutic efficacy of Egaptivon pegol can be decreased when used in combination with Pegaptanib.
PEG-uricase The therapeutic efficacy of PEG-uricase can be decreased when used in combination with Pegaptanib.
Peginterferon alfacon-1 The therapeutic efficacy of Peginterferon alfacon-1 can be decreased when used in combination with Pegaptanib.
GlycoPEG-GCSF The therapeutic efficacy of GlycoPEG-GCSF can be decreased when used in combination with Pegaptanib.
Pegnivacogin The therapeutic efficacy of Pegnivacogin can be decreased when used in combination with Pegaptanib.
Pegpleranib The therapeutic efficacy of Pegpleranib can be decreased when used in combination with Pegaptanib.
Pegsunercept The therapeutic efficacy of Pegsunercept can be decreased when used in combination with Pegaptanib.
Polidocanol The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegaptanib.
Methoxy polyethylene glycol-epoetin beta The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Pegaptanib.
Peginterferon beta-1a The therapeutic efficacy of Peginterferon beta-1a can be decreased when used in combination with Pegaptanib.
Pegloticase The therapeutic efficacy of Pegloticase can be decreased when used in combination with Pegaptanib.
Polyethylene glycol The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Pegaptanib.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be decreased when used in combination with Pegaptanib.
Eptacog alfa pegol (activated) The therapeutic efficacy of Eptacog alfa pegol (activated) can be decreased when used in combination with Pegaptanib.
Olaptesed Pegol The therapeutic efficacy of Olaptesed Pegol can be decreased when used in combination with Pegaptanib.
Abicipar Pegol The therapeutic efficacy of Abicipar Pegol can be decreased when used in combination with Pegaptanib.
Lexaptepid pegol The therapeutic efficacy of Lexaptepid pegol can be decreased when used in combination with Pegaptanib.
Cepeginterferon alfa-2B The therapeutic efficacy of Cepeginterferon alfa-2B can be decreased when used in combination with Pegaptanib.
Pegvaliase The therapeutic efficacy of Pegvaliase can be decreased when used in combination with Pegaptanib.
Pegamotecan The therapeutic efficacy of Pegamotecan can be decreased when used in combination with Pegaptanib.
Lipegfilgrastim The therapeutic efficacy of Lipegfilgrastim can be decreased when used in combination with Pegaptanib.
Nonacog beta pegol The therapeutic efficacy of Nonacog beta pegol can be decreased when used in combination with Pegaptanib.
Damoctocog alfa pegol The therapeutic efficacy of Damoctocog alfa pegol can be decreased when used in combination with Pegaptanib.
Elapegademase The therapeutic efficacy of Elapegademase can be decreased when used in combination with Pegaptanib.
Cyclosporine Cyclosporine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.

Target Protein

Vascular endothelial growth factor A, long form VEGFA

Referensi & Sumber

Artikel (PubMed)

Contoh Produk & Brand

Produk: 3 • International brands: 0
Produk
  • Macugen
    Injection, solution • 3.47 mg/1mL • Intravitreal • US • Approved
  • Macugen
    Solution • 0.3 mg / 90 mcL • Intravitreal • Canada • Approved
  • Macugen
    Injection, solution • 0.3 mg • Intravitreal • EU

Sekuens Gen/Protein (FASTA)

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