Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Deferasirox | The serum concentration of Bicifadine can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Bicifadine can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Bicifadine can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Bicifadine can be decreased when it is combined with Teriflunomide. |
| Mirabegron | The serum concentration of Bicifadine can be increased when it is combined with Mirabegron. |
| Abiraterone | The serum concentration of Bicifadine can be increased when it is combined with Abiraterone. |
| Cyproterone acetate | The metabolism of Bicifadine can be increased when combined with Cyproterone acetate. |
| Carbamazepine | The metabolism of Bicifadine can be increased when combined with Carbamazepine. |
| Primidone | The metabolism of Bicifadine can be increased when combined with Primidone. |
| Rifampin | The metabolism of Bicifadine can be increased when combined with Rifampicin. |
| Albendazole | The metabolism of Bicifadine can be increased when combined with Albendazole. |
| Caffeine | The metabolism of Bicifadine can be decreased when combined with Caffeine. |
| Moxifloxacin | The metabolism of Bicifadine can be decreased when combined with Moxifloxacin. |
| Lidocaine | The metabolism of Bicifadine can be decreased when combined with Lidocaine. |
| Mexiletine | The metabolism of Bicifadine can be decreased when combined with Mexiletine. |
| Alosetron | The metabolism of Bicifadine can be decreased when combined with Alosetron. |
| Gatifloxacin | The metabolism of Bicifadine can be decreased when combined with Gatifloxacin. |
| Simeprevir | The metabolism of Bicifadine can be decreased when combined with Simeprevir. |
| Lobeglitazone | The metabolism of Bicifadine can be decreased when combined with Lobeglitazone. |
| Pazufloxacin | The metabolism of Bicifadine can be decreased when combined with Pazufloxacin. |
| Osilodrostat | The metabolism of Bicifadine can be decreased when combined with Osilodrostat. |
| Imipramine | The metabolism of Bicifadine can be decreased when combined with Imipramine. |
| Ketoconazole | The metabolism of Bicifadine can be decreased when combined with Ketoconazole. |
| Dosulepin | The metabolism of Bicifadine can be decreased when combined with Dosulepin. |
| Cyclosporine | The metabolism of Bicifadine can be decreased when combined with Cyclosporine. |
| Cholecalciferol | The metabolism of Bicifadine can be decreased when combined with Cholecalciferol. |
| Fluvoxamine | The metabolism of Bicifadine can be decreased when combined with Fluvoxamine. |
| Metoprolol | The metabolism of Bicifadine can be decreased when combined with Metoprolol. |
| Venlafaxine | The metabolism of Bicifadine can be decreased when combined with Venlafaxine. |
| Terfenadine | The metabolism of Bicifadine can be decreased when combined with Terfenadine. |
| Clobazam | The serum concentration of Bicifadine can be increased when it is combined with Clobazam. |
| Clozapine | The serum concentration of Bicifadine can be increased when it is combined with Clozapine. |
| Quinine | The metabolism of Bicifadine can be decreased when combined with Quinine. |
| Duloxetine | The metabolism of Bicifadine can be decreased when combined with Duloxetine. |
| Chlorpromazine | The metabolism of Bicifadine can be decreased when combined with Chlorpromazine. |
| Celecoxib | The metabolism of Bicifadine can be decreased when combined with Celecoxib. |
| Darifenacin | The metabolism of Bicifadine can be decreased when combined with Darifenacin. |
| Cimetidine | The metabolism of Bicifadine can be decreased when combined with Cimetidine. |
| Ritonavir | The metabolism of Bicifadine can be decreased when combined with Ritonavir. |
| Chloroquine | The metabolism of Bicifadine can be decreased when combined with Chloroquine. |
| Delavirdine | The metabolism of Bicifadine can be decreased when combined with Delavirdine. |
| Tranylcypromine | The metabolism of Bicifadine can be decreased when combined with Tranylcypromine. |
| Terbinafine | The metabolism of Bicifadine can be decreased when combined with Terbinafine. |
| Tipranavir | The metabolism of Bicifadine can be decreased when combined with Tipranavir. |
| Perhexiline | The metabolism of Bicifadine can be decreased when combined with Perhexiline. |
| Tegaserod | The metabolism of Bicifadine can be decreased when combined with Tegaserod. |
| Primaquine | The metabolism of Bicifadine can be decreased when combined with Primaquine. |
| Desipramine | The metabolism of Bicifadine can be decreased when combined with Desipramine. |
| Fusidic acid | The metabolism of Bicifadine can be decreased when combined with Fusidic acid. |
| Panobinostat | The metabolism of Bicifadine can be decreased when combined with Panobinostat. |
| Vilazodone | The metabolism of Bicifadine can be decreased when combined with Vilazodone. |
| Lumefantrine | The metabolism of Bicifadine can be decreased when combined with Lumefantrine. |
| Sulfaphenazole | The metabolism of Bicifadine can be decreased when combined with Sulfaphenazole. |
| Phenylbutyric acid | The metabolism of Bicifadine can be decreased when combined with Phenylbutyric acid. |
| Manidipine | The metabolism of Bicifadine can be decreased when combined with Manidipine. |
| Rolapitant | The metabolism of Bicifadine can be decreased when combined with Rolapitant. |
| Asunaprevir | The metabolism of Bicifadine can be decreased when combined with Asunaprevir. |
| Pitolisant | The metabolism of Bicifadine can be decreased when combined with Pitolisant. |
| Rucaparib | The metabolism of Bicifadine can be decreased when combined with Rucaparib. |
| Ritanserin | The metabolism of Bicifadine can be decreased when combined with Ritanserin. |
| Rhein | The metabolism of Bicifadine can be decreased when combined with Rhein. |
| Lorcaserin | The metabolism of Bicifadine can be decreased when combined with Lorcaserin. |
| Nicardipine | The metabolism of Bicifadine can be decreased when combined with Nicardipine. |
| Berotralstat | The metabolism of Bicifadine can be decreased when combined with Berotralstat. |
| Cisapride | The metabolism of Bicifadine can be decreased when combined with Cisapride. |
| Thioridazine | The metabolism of Bicifadine can be decreased when combined with Thioridazine. |
| Paroxetine | The metabolism of Bicifadine can be decreased when combined with Paroxetine. |
| Quinidine | The metabolism of Bicifadine can be decreased when combined with Quinidine. |
| Cinacalcet | The metabolism of Bicifadine can be decreased when combined with Cinacalcet. |
| Bupropion | The metabolism of Bicifadine can be decreased when combined with Bupropion. |
| Orphenadrine | The metabolism of Bicifadine can be decreased when combined with Orphenadrine. |
| Propafenone | The metabolism of Bicifadine can be decreased when combined with Propafenone. |
| Halofantrine | The metabolism of Bicifadine can be decreased when combined with Halofantrine. |
| Methotrimeprazine | The metabolism of Bicifadine can be decreased when combined with Methotrimeprazine. |
| Glycerol phenylbutyrate | The metabolism of Bicifadine can be decreased when combined with Glycerol phenylbutyrate. |
| Osimertinib | The serum concentration of Bicifadine can be decreased when it is combined with Osimertinib. |
| Vemurafenib | The serum concentration of Bicifadine can be increased when it is combined with Vemurafenib. |
| Ticlopidine | The metabolism of Bicifadine can be decreased when combined with Ticlopidine. |
| Citalopram | The metabolism of Bicifadine can be decreased when combined with Citalopram. |
| Clemastine | The metabolism of Bicifadine can be decreased when combined with Clemastine. |
| Methadone | The metabolism of Bicifadine can be decreased when combined with Methadone. |
| Cerivastatin | The metabolism of Bicifadine can be decreased when combined with Cerivastatin. |
| Hydroxyzine | The metabolism of Bicifadine can be decreased when combined with Hydroxyzine. |
| Fenfluramine | The metabolism of Bicifadine can be decreased when combined with Fenfluramine. |
| Labetalol | The metabolism of Bicifadine can be decreased when combined with Labetalol. |
| Dexmedetomidine | The metabolism of Bicifadine can be decreased when combined with Dexmedetomidine. |
| Dextropropoxyphene | The metabolism of Bicifadine can be decreased when combined with Dextropropoxyphene. |
| Methimazole | The metabolism of Bicifadine can be decreased when combined with Methimazole. |
| Tripelennamine | The metabolism of Bicifadine can be decreased when combined with Tripelennamine. |
| Biperiden | The metabolism of Bicifadine can be decreased when combined with Biperiden. |
| Mifepristone | The metabolism of Bicifadine can be decreased when combined with Mifepristone. |
| Perphenazine | The metabolism of Bicifadine can be decreased when combined with Perphenazine. |
| Ranitidine | The metabolism of Bicifadine can be decreased when combined with Ranitidine. |
| Cocaine | The metabolism of Bicifadine can be decreased when combined with Cocaine. |
| Azelastine | The metabolism of Bicifadine can be decreased when combined with Azelastine. |
| Doxorubicin | The metabolism of Bicifadine can be decreased when combined with Doxorubicin. |
| Felodipine | The metabolism of Bicifadine can be decreased when combined with Felodipine. |
| Oxybutynin | The metabolism of Bicifadine can be decreased when combined with Oxybutynin. |
| Promethazine | The metabolism of Bicifadine can be decreased when combined with Promethazine. |
| Diphenhydramine | The metabolism of Bicifadine can be decreased when combined with Diphenhydramine. |