Voglibose

DB04878

small molecule investigational

Deskripsi

Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix.

Struktur Molekul 2D

Berat 267.2762
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life of voglibose is very similar to the one found for metformin and it is reported to be of 4.08 hours.[A38919]
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Slowly and poorly absorbed. The reported pharmacokinetic parameters of voglibose with metformin are Cmax corresponds to 1.38 mcg/ml while AUC is 8.17 mcg.h/ml and tmax is of 2.5 hours.A38919

Metabolisme

Little metabolism occurs and no metabolites have as yet been identified.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

604 Data
Pegvisomant The risk or severity of hypoglycemia can be increased when Pegvisomant is combined with Voglibose.
Lipoic acid The risk or severity of hypoglycemia can be increased when Lipoic acid is combined with Voglibose.
Moxifloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Moxifloxacin.
Grepafloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Grepafloxacin.
Enoxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Enoxacin.
Pefloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Pefloxacin.
Ciprofloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Ciprofloxacin.
Trovafloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Trovafloxacin.
Nalidixic acid The therapeutic efficacy of Voglibose can be increased when used in combination with Nalidixic acid.
Rosoxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Rosoxacin.
Cinoxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Cinoxacin.
Lomefloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Lomefloxacin.
Gatifloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Gatifloxacin.
Norfloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Norfloxacin.
Levofloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Levofloxacin.
Gemifloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Gemifloxacin.
Ofloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Ofloxacin.
Sparfloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Sparfloxacin.
Temafloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Temafloxacin.
Fleroxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Fleroxacin.
Technetium Tc-99m ciprofloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Technetium Tc-99m ciprofloxacin.
Garenoxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Garenoxacin.
Nemonoxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Nemonoxacin.
Flumequine The therapeutic efficacy of Voglibose can be increased when used in combination with Flumequine.
Enrofloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Enrofloxacin.
Orbifloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Orbifloxacin.
Sarafloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Sarafloxacin.
Difloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Difloxacin.
Pazufloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Pazufloxacin.
Prulifloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Prulifloxacin.
Delafloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Delafloxacin.
Sitafloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Sitafloxacin.
Oxolinic acid The therapeutic efficacy of Voglibose can be increased when used in combination with Oxolinic acid.
Rufloxacin The therapeutic efficacy of Voglibose can be increased when used in combination with Rufloxacin.
Pipemidic acid The therapeutic efficacy of Voglibose can be increased when used in combination with Pipemidic acid.
Methyclothiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Methyclothiazide.
Chlorthalidone The therapeutic efficacy of Voglibose can be decreased when used in combination with Chlorthalidone.
Bendroflumethiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Bendroflumethiazide.
Metolazone The therapeutic efficacy of Voglibose can be decreased when used in combination with Metolazone.
Benzthiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Benzthiazide.
Hydroflumethiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Hydroflumethiazide.
Indapamide The therapeutic efficacy of Voglibose can be decreased when used in combination with Indapamide.
Chlorothiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Chlorothiazide.
Hydrochlorothiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Hydrochlorothiazide.
Trichlormethiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Trichlormethiazide.
Polythiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Polythiazide.
Quinethazone The therapeutic efficacy of Voglibose can be decreased when used in combination with Quinethazone.
Cyclopenthiazide The therapeutic efficacy of Voglibose can be decreased when used in combination with Cyclopenthiazide.
Epitizide The therapeutic efficacy of Voglibose can be decreased when used in combination with Epitizide.
Amitriptyline Amitriptyline may decrease the hypoglycemic activities of Voglibose.
Protriptyline Protriptyline may decrease the hypoglycemic activities of Voglibose.
Imipramine Imipramine may decrease the hypoglycemic activities of Voglibose.
Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Voglibose.
Amoxapine Amoxapine may decrease the hypoglycemic activities of Voglibose.
Trimipramine Trimipramine may decrease the hypoglycemic activities of Voglibose.
Doxepin Doxepin may decrease the hypoglycemic activities of Voglibose.
Desipramine Desipramine may decrease the hypoglycemic activities of Voglibose.
Clomipramine Clomipramine may decrease the hypoglycemic activities of Voglibose.
Amineptine Amineptine may decrease the hypoglycemic activities of Voglibose.
Dimetacrine Dimetacrine may decrease the hypoglycemic activities of Voglibose.
Butriptyline Butriptyline may decrease the hypoglycemic activities of Voglibose.
Dosulepin Dosulepin may decrease the hypoglycemic activities of Voglibose.
Tianeptine Tianeptine may decrease the hypoglycemic activities of Voglibose.
Oxaprotiline Oxaprotiline may decrease the hypoglycemic activities of Voglibose.
Opipramol Opipramol may decrease the hypoglycemic activities of Voglibose.
Amitriptylinoxide Amitriptylinoxide may decrease the hypoglycemic activities of Voglibose.
Dibenzepin Dibenzepin may decrease the hypoglycemic activities of Voglibose.
Quinupramine Quinupramine may decrease the hypoglycemic activities of Voglibose.
Melitracen Melitracen may decrease the hypoglycemic activities of Voglibose.
Lofepramine Lofepramine may decrease the hypoglycemic activities of Voglibose.
Iprindole Iprindole may decrease the hypoglycemic activities of Voglibose.
Imipramine oxide Imipramine oxide may decrease the hypoglycemic activities of Voglibose.
Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Voglibose.
Canagliflozin Canagliflozin may increase the hypoglycemic activities of Voglibose.
Leuprolide The therapeutic efficacy of Voglibose can be decreased when used in combination with Leuprolide.
Goserelin The therapeutic efficacy of Voglibose can be decreased when used in combination with Goserelin.
Nelfinavir The therapeutic efficacy of Voglibose can be decreased when used in combination with Nelfinavir.
Indinavir The therapeutic efficacy of Voglibose can be decreased when used in combination with Indinavir.
Ziprasidone The therapeutic efficacy of Voglibose can be decreased when used in combination with Ziprasidone.
Etonogestrel The therapeutic efficacy of Voglibose can be decreased when used in combination with Etonogestrel.
Desogestrel The therapeutic efficacy of Voglibose can be decreased when used in combination with Desogestrel.
Olanzapine The therapeutic efficacy of Voglibose can be decreased when used in combination with Olanzapine.
Megestrol acetate The therapeutic efficacy of Voglibose can be decreased when used in combination with Megestrol acetate.
Clozapine The therapeutic efficacy of Voglibose can be decreased when used in combination with Clozapine.
Levonorgestrel The therapeutic efficacy of Voglibose can be decreased when used in combination with Levonorgestrel.
Progesterone The therapeutic efficacy of Voglibose can be decreased when used in combination with Progesterone.
Chlorpromazine The therapeutic efficacy of Voglibose can be decreased when used in combination with Chlorpromazine.
Haloperidol The therapeutic efficacy of Voglibose can be decreased when used in combination with Haloperidol.
Ritonavir The therapeutic efficacy of Voglibose can be decreased when used in combination with Ritonavir.
Piperazine The therapeutic efficacy of Voglibose can be decreased when used in combination with Piperazine.
Medroxyprogesterone acetate The therapeutic efficacy of Voglibose can be decreased when used in combination with Medroxyprogesterone acetate.
Niacin The therapeutic efficacy of Voglibose can be decreased when used in combination with Niacin.
Epinephrine The therapeutic efficacy of Voglibose can be decreased when used in combination with Epinephrine.
Norethisterone The therapeutic efficacy of Voglibose can be decreased when used in combination with Norethisterone.
Risperidone The therapeutic efficacy of Voglibose can be decreased when used in combination with Risperidone.
Pentamidine The therapeutic efficacy of Voglibose can be decreased when used in combination with Pentamidine.
Ethynodiol diacetate The therapeutic efficacy of Voglibose can be decreased when used in combination with Ethynodiol diacetate.
Pseudoephedrine The therapeutic efficacy of Voglibose can be decreased when used in combination with Pseudoephedrine.
Tacrolimus The therapeutic efficacy of Voglibose can be decreased when used in combination with Tacrolimus.
Sirolimus The therapeutic efficacy of Voglibose can be decreased when used in combination with Sirolimus.

Target Protein

Maltase-glucoamylase MGAM

Referensi & Sumber

Synthesis reference: Heinz G. Floss, Sungsook Lee, Ingo Tornus, "Valiolone, a method of preparing it, and its use to prepare acarbose and voglibose." U.S. Patent US6150568, issued October, 1995.
Artikel (PubMed)
  • PMID: 17509067
    Aso Y, Yamamoto R, Suetsugu M, Matsumoto S, Wakabayashi S, Matsutomo R, Takebayashi K, Inukai T: Comparison of the effects of pioglitazone and voglibose on circulating total and high-molecular-weight adiponectin, and on two fibrinolysis inhibitors, in patients with Type 2 diabetes. Diabet Med. 2007 Sep;24(9):962-8. Epub 2007 May 17.
  • PMID: 16618980
    Kurebayashi S, Watada H, Tanaka Y, Kawasumi M, Kawamori R, Hirose T: Efficacy and adverse effects of nateglinide in early type 2 diabetes. Comparison with voglibose in a cross-over study. Endocr J. 2006 Apr;53(2):213-7.
  • PMID: 16713439
    Satoh N, Shimatsu A, Yamada K, Aizawa-Abe M, Suganami T, Kuzuya H, Ogawa Y: An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients. Metabolism. 2006 Jun;55(6):786-93.
  • PMID: 25546164
    Choi HK, Oh M, Kim EJ, Song GS, Ghim JL, Shon JH, Kim HS, Shin JG: Pharmacokinetic study of metformin to compare voglibose/metformin fixed-dose combination with coadministered voglibose and metformin. Int J Clin Pharmacol Ther. 2015 Feb;53(2):147-53. doi: 10.5414/CP202197.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Basen — Takeda Chemical Industries
  • Glustat
  • Volix — Ranbaxy labs

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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