Huperzine A

DB04864

small molecule approved experimental

Deskripsi

Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer’s disease.

Struktur Molekul 2D

Berat 242.3162
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

292 Data
Dipyridamole The therapeutic efficacy of Huperzine A can be decreased when used in combination with Dipyridamole.
Ephedrine Huperzine A may increase the neuromuscular blocking activities of Ephedrine.
Bambuterol Huperzine A may increase the neuromuscular blocking activities of Bambuterol.
Clevidipine Huperzine A may increase the neuromuscular blocking activities of Clevidipine.
Sar9, Met (O2)11-Substance P Huperzine A may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P.
Mirabegron Huperzine A may increase the neuromuscular blocking activities of Mirabegron.
Moxisylyte Huperzine A may increase the neuromuscular blocking activities of Moxisylyte.
Propacetamol Huperzine A may increase the neuromuscular blocking activities of Propacetamol.
Procaine Huperzine A may increase the neuromuscular blocking activities of Procaine.
Cocaine Huperzine A may increase the neuromuscular blocking activities of Cocaine.
Trimethaphan Huperzine A may increase the neuromuscular blocking activities of Trimethaphan.
Doxacurium Huperzine A may increase the neuromuscular blocking activities of Doxacurium.
Chloroprocaine Huperzine A may increase the neuromuscular blocking activities of Chloroprocaine.
Tubocurarine Huperzine A may increase the neuromuscular blocking activities of Tubocurarine.
Aclidinium Huperzine A may increase the neuromuscular blocking activities of Aclidinium.
Butyrylthiocholine Huperzine A may increase the neuromuscular blocking activities of Butyrylthiocholine.
Oxybuprocaine Huperzine A may increase the neuromuscular blocking activities of Oxybuprocaine.
Benzonatate Huperzine A may increase the neuromuscular blocking activities of Benzonatate.
Succinylcholine The metabolism of Succinylcholine can be decreased when combined with Huperzine A.
Tramadol The therapeutic efficacy of Tramadol can be decreased when used in combination with Huperzine A.
Trospium The therapeutic efficacy of Trospium can be decreased when used in combination with Huperzine A.
Oxyphenonium The therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Huperzine A.
Butabarbital The therapeutic efficacy of Butabarbital can be decreased when used in combination with Huperzine A.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Huperzine A.
Benzatropine The therapeutic efficacy of Benzatropine can be decreased when used in combination with Huperzine A.
Ziprasidone The therapeutic efficacy of Ziprasidone can be decreased when used in combination with Huperzine A.
Disopyramide The therapeutic efficacy of Disopyramide can be decreased when used in combination with Huperzine A.
Talbutal The therapeutic efficacy of Talbutal can be decreased when used in combination with Huperzine A.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Huperzine A.
Amitriptyline The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Huperzine A.
Ipratropium The therapeutic efficacy of Ipratropium can be decreased when used in combination with Huperzine A.
Methadone The therapeutic efficacy of Methadone can be decreased when used in combination with Huperzine A.
Olanzapine The therapeutic efficacy of Olanzapine can be decreased when used in combination with Huperzine A.
Metixene The therapeutic efficacy of Metixene can be decreased when used in combination with Huperzine A.
Terfenadine The therapeutic efficacy of Terfenadine can be decreased when used in combination with Huperzine A.
Buclizine The therapeutic efficacy of Buclizine can be decreased when used in combination with Huperzine A.
Clozapine The therapeutic efficacy of Clozapine can be decreased when used in combination with Huperzine A.
Doxylamine The therapeutic efficacy of Doxylamine can be decreased when used in combination with Huperzine A.
Trihexyphenidyl The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Huperzine A.
Oxyphencyclimine The therapeutic efficacy of Oxyphencyclimine can be decreased when used in combination with Huperzine A.
Procyclidine The therapeutic efficacy of Procyclidine can be decreased when used in combination with Huperzine A.
Profenamine The therapeutic efficacy of Profenamine can be decreased when used in combination with Huperzine A.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Huperzine A.
Promazine The therapeutic efficacy of Promazine can be decreased when used in combination with Huperzine A.
Hyoscyamine The therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Huperzine A.
Cyproheptadine The therapeutic efficacy of Cyproheptadine can be decreased when used in combination with Huperzine A.
Imipramine The therapeutic efficacy of Imipramine can be decreased when used in combination with Huperzine A.
Methscopolamine bromide The therapeutic efficacy of Methscopolamine bromide can be decreased when used in combination with Huperzine A.
Metharbital The therapeutic efficacy of Metharbital can be decreased when used in combination with Huperzine A.
Fluoxetine The therapeutic efficacy of Fluoxetine can be decreased when used in combination with Huperzine A.
Chlorpromazine The therapeutic efficacy of Chlorpromazine can be decreased when used in combination with Huperzine A.
Darifenacin The therapeutic efficacy of Darifenacin can be decreased when used in combination with Huperzine A.
Tridihexethyl The therapeutic efficacy of Tridihexethyl can be decreased when used in combination with Huperzine A.
Triflupromazine The therapeutic efficacy of Triflupromazine can be decreased when used in combination with Huperzine A.
Dextromethorphan The therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Huperzine A.
Anisotropine methylbromide The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Huperzine A.
Nortriptyline The therapeutic efficacy of Nortriptyline can be decreased when used in combination with Huperzine A.
Amoxapine The therapeutic efficacy of Amoxapine can be decreased when used in combination with Huperzine A.
Atropine The therapeutic efficacy of Atropine can be decreased when used in combination with Huperzine A.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Huperzine A.
Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Huperzine A.
Mecamylamine The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Huperzine A.
Pirenzepine The therapeutic efficacy of Pirenzepine can be decreased when used in combination with Huperzine A.
Paroxetine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Huperzine A.
Homatropine methylbromide The therapeutic efficacy of Homatropine methylbromide can be decreased when used in combination with Huperzine A.
Scopolamine The therapeutic efficacy of Scopolamine can be decreased when used in combination with Huperzine A.
Isoflurane The therapeutic efficacy of Isoflurane can be decreased when used in combination with Huperzine A.
Benzquinamide The therapeutic efficacy of Benzquinamide can be decreased when used in combination with Huperzine A.
Clidinium The therapeutic efficacy of Clidinium can be decreased when used in combination with Huperzine A.
Propiomazine The therapeutic efficacy of Propiomazine can be decreased when used in combination with Huperzine A.
Propantheline The therapeutic efficacy of Propantheline can be decreased when used in combination with Huperzine A.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Huperzine A.
Dicyclomine The therapeutic efficacy of Dicyclomine can be decreased when used in combination with Huperzine A.
Biperiden The therapeutic efficacy of Biperiden can be decreased when used in combination with Huperzine A.
Brompheniramine The therapeutic efficacy of Brompheniramine can be decreased when used in combination with Huperzine A.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Huperzine A.
Quinidine The therapeutic efficacy of Quinidine can be decreased when used in combination with Huperzine A.
Amantadine The therapeutic efficacy of Amantadine can be decreased when used in combination with Huperzine A.
Maprotiline The therapeutic efficacy of Maprotiline can be decreased when used in combination with Huperzine A.
Methantheline The therapeutic efficacy of Methantheline can be decreased when used in combination with Huperzine A.
Hexafluronium The therapeutic efficacy of Hexafluronium can be decreased when used in combination with Huperzine A.
Cycrimine The therapeutic efficacy of Cycrimine can be decreased when used in combination with Huperzine A.
Desloratadine The therapeutic efficacy of Desloratadine can be decreased when used in combination with Huperzine A.
Glycopyrronium The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Huperzine A.
Tolterodine The therapeutic efficacy of Tolterodine can be decreased when used in combination with Huperzine A.
Oxybutynin The therapeutic efficacy of Oxybutynin can be decreased when used in combination with Huperzine A.
Promethazine The therapeutic efficacy of Promethazine can be decreased when used in combination with Huperzine A.
Diphenhydramine The therapeutic efficacy of Diphenhydramine can be decreased when used in combination with Huperzine A.
Pentolinium The therapeutic efficacy of Pentolinium can be decreased when used in combination with Huperzine A.
Doxepin The therapeutic efficacy of Doxepin can be decreased when used in combination with Huperzine A.
Flavoxate The therapeutic efficacy of Flavoxate can be decreased when used in combination with Huperzine A.
Desipramine The therapeutic efficacy of Desipramine can be decreased when used in combination with Huperzine A.
Orphenadrine The therapeutic efficacy of Orphenadrine can be decreased when used in combination with Huperzine A.
Phenobarbital The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Huperzine A.
Escitalopram The therapeutic efficacy of Escitalopram can be decreased when used in combination with Huperzine A.
Quetiapine The therapeutic efficacy of Quetiapine can be decreased when used in combination with Huperzine A.
Levacetylmethadol The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Huperzine A.
Diphenidol The therapeutic efficacy of Diphenidol can be decreased when used in combination with Huperzine A.
Aripiprazole The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Huperzine A.
Chlorprothixene The therapeutic efficacy of Chlorprothixene can be decreased when used in combination with Huperzine A.

Target Protein

Acetylcholinesterase ACHE

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18230054
    Little JT, Walsh S, Aisen PS: An update on huperzine A as a treatment for Alzheimer's disease. Expert Opin Investig Drugs. 2008 Feb;17(2):209-15. doi: 10.1517/13543784.17.2.209.
  • PMID: 17908041
    Li WM, Kan KK, Carlier PR, Pang YP, Han YF: East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A. Curr Alzheimer Res. 2007 Sep;4(4):386-96.
  • PMID: 17305579
    Haviv H, Wong DM, Silman I, Sussman JL: Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors. Curr Top Med Chem. 2007;7(4):375-87.
  • PMID: 16634467
    Akhondzadeh S, Abbasi SH: Herbal medicine in the treatment of Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2006 Mar-Apr;21(2):113-8.
  • PMID: 16364207
    Wang R, Yan H, Tang XC: Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006 Jan;27(1):1-26.
  • PMID: 15956816
    Wang R, Tang XC: Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease. Neurosignals. 2005;14(1-2):71-82.
  • PMID: 14725492
    Authors unspecified: Huperzine A. Drugs R D. 2004;5(1):44-5.
  • PMID: 14529340
    Jiang H, Luo X, Bai D: Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional chinese medicine origin for the treatment of Alzheimer's disease. Curr Med Chem. 2003 Nov;10(21):2231-52.
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