Biricodar

DB04851

small molecule investigational

Deskripsi

The pipecolinate derivative biricodar (VX-710) is a clinically applicable modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1).

Struktur Molekul 2D

Berat 603.716
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

160 Data
Afatinib The serum concentration of Afatinib can be increased when it is combined with Biricodar.
Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Biricodar.
Brentuximab vedotin The serum concentration of Brentuximab vedotin can be increased when it is combined with Biricodar.
Colchicine The serum concentration of Colchicine can be increased when it is combined with Biricodar.
Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Biricodar.
Ledipasvir The serum concentration of Ledipasvir can be increased when it is combined with Biricodar.
Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Biricodar.
Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Biricodar.
Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Biricodar.
Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Biricodar.
Silodosin The excretion of Silodosin can be decreased when combined with Biricodar.
Topotecan The serum concentration of Topotecan can be increased when it is combined with Biricodar.
Everolimus The serum concentration of Everolimus can be increased when it is combined with Biricodar.
Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Biricodar.
Vincristine The excretion of Vincristine can be decreased when combined with Biricodar.
Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Biricodar.
Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Biricodar.
Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Biricodar.
Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Biricodar.
Morphine The serum concentration of Morphine can be increased when it is combined with Biricodar.
Tenofovir disoproxil The serum concentration of Tenofovir disoproxil can be increased when it is combined with Biricodar.
Clobazam The serum concentration of Clobazam can be increased when it is combined with Biricodar.
Quinine The serum concentration of Quinine can be increased when it is combined with Biricodar.
Toremifene The serum concentration of Toremifene can be increased when it is combined with Biricodar.
Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Biricodar.
Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Biricodar.
Mannitol The serum concentration of Mannitol can be increased when it is combined with Biricodar.
Loperamide The excretion of Loperamide can be decreased when combined with Biricodar.
Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Biricodar.
Clomifene The serum concentration of Clomifene can be increased when it is combined with Biricodar.
Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Biricodar.
Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Biricodar.
Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Biricodar.
Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Biricodar.
Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Biricodar.
Paliperidone The serum concentration of Paliperidone can be increased when it is combined with Biricodar.
Belinostat The serum concentration of Belinostat can be increased when it is combined with Biricodar.
Indacaterol The serum concentration of Indacaterol can be increased when it is combined with Biricodar.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Biricodar.
Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Biricodar.
Simeprevir The serum concentration of Simeprevir can be increased when it is combined with Biricodar.
Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Biricodar.
Apixaban The serum concentration of Apixaban can be increased when it is combined with Biricodar.
Odanacatib The serum concentration of Odanacatib can be increased when it is combined with Biricodar.
Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Biricodar.
Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Biricodar.
Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Biricodar.
Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Biricodar.
Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Biricodar.
Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Biricodar.
Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Biricodar.
Umeclidinium The serum concentration of Umeclidinium can be increased when it is combined with Biricodar.
Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Biricodar.
Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Biricodar.
Technetium Tc-99m sestamibi The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Biricodar.
Dasabuvir The serum concentration of Dasabuvir can be increased when it is combined with Biricodar.
Ombitasvir The serum concentration of Ombitasvir can be increased when it is combined with Biricodar.
Paritaprevir The serum concentration of Paritaprevir can be increased when it is combined with Biricodar.
Selexipag The serum concentration of Selexipag can be increased when it is combined with Biricodar.
Elbasvir The serum concentration of Elbasvir can be increased when it is combined with Biricodar.
Grazoprevir The serum concentration of Grazoprevir can be increased when it is combined with Biricodar.
Velpatasvir The serum concentration of Velpatasvir can be increased when it is combined with Biricodar.
Tezacaftor The serum concentration of Tezacaftor can be increased when it is combined with Biricodar.
Talinolol The serum concentration of Talinolol can be increased when it is combined with Biricodar.
Revefenacin The serum concentration of Revefenacin can be increased when it is combined with Biricodar.
Valspodar The serum concentration of Valspodar can be increased when it is combined with Biricodar.
Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Biricodar.
Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Biricodar.
Elagolix The serum concentration of Elagolix can be increased when it is combined with Biricodar.
Voxilaprevir The serum concentration of Voxilaprevir can be increased when it is combined with Biricodar.
Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Biricodar.
Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Biricodar.
Grapiprant The serum concentration of Grapiprant can be increased when it is combined with Biricodar.
Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Biricodar.
Pibrentasvir The serum concentration of Pibrentasvir can be increased when it is combined with Biricodar.
Glecaprevir The serum concentration of Glecaprevir can be increased when it is combined with Biricodar.
Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Biricodar.
Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Biricodar.
Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Biricodar.
Enfortumab vedotin The serum concentration of Enfortumab vedotin can be increased when it is combined with Biricodar.
Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Biricodar.
Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Biricodar.
Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Biricodar.
Mibefradil The serum concentration of Mibefradil can be increased when it is combined with Biricodar.
Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Biricodar.
Methylene blue The serum concentration of Methylene blue can be increased when it is combined with Biricodar.
Tucatinib The serum concentration of Tucatinib can be increased when it is combined with Biricodar.
Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Biricodar.
Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Biricodar.
Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Biricodar.
Prednisolone phosphate The serum concentration of Prednisolone phosphate can be increased when it is combined with Biricodar.
Belantamab mafodotin The serum concentration of Belantamab mafodotin can be increased when it is combined with Biricodar.
Mefloquine The serum concentration of Mefloquine can be increased when it is combined with Biricodar.
Cethromycin The serum concentration of Cethromycin can be increased when it is combined with Biricodar.
Darunavir The serum concentration of Darunavir can be increased when it is combined with Biricodar.
Voclosporin The serum concentration of Voclosporin can be increased when it is combined with Biricodar.
Trilaciclib The serum concentration of Trilaciclib can be increased when it is combined with Biricodar.
Daptomycin The serum concentration of Daptomycin can be increased when it is combined with Biricodar.
Avanafil The serum concentration of Avanafil can be increased when it is combined with Biricodar.
Tivozanib The serum concentration of Tivozanib can be increased when it is combined with Biricodar.

Target Protein

ATP-dependent translocase ABCB1 ABCB1
ATP-binding cassette sub-family B member 5 ABCB5
Multidrug resistance-associated protein 1 ABCC1
Broad substrate specificity ATP-binding cassette transporter ABCG2 ABCG2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17285598
    Gandhi L, Harding MW, Neubauer M, Langer CJ, Moore M, Ross HJ, Johnson BE, Lynch TJ: A phase II study of the safety and efficacy of the multidrug resistance inhibitor VX-710 combined with doxorubicin and vincristine in patients with recurrent small cell lung cancer. Cancer. 2007 Mar 1;109(5):924-32.
  • PMID: 15504837
    Mullin S, Mani N, Grossman TH: Inhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitors biricodar (VX-710) and timcodar (VX-853). Antimicrob Agents Chemother. 2004 Nov;48(11):4171-6.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
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Sekuens Gen/Protein (FASTA)

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