Fluspirilene

DB04842

small molecule approved investigational

Deskripsi

A long-acting injectable antipsychotic agent used for chronic schizophrenia.

Struktur Molekul 2D

Berat 475.5727
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Avoid alcohol.

Interaksi Obat

1531 Data
Ceritinib Fluspirilene may increase the bradycardic activities of Ceritinib.
Ivabradine Fluspirilene may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Fluspirilene.
Buprenorphine Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Hydrocodone Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Fluspirilene can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Orphenadrine Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Rotigotine Fluspirilene may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Fluspirilene.
Sodium oxybate The risk or severity of CNS depression can be increased when Fluspirilene is combined with Sodium oxybate.
Suvorexant Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Thalidomide Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Amisulpride Fluspirilene may increase the antipsychotic activities of Amisulpride.
Methylphenidate The risk or severity of adverse effects can be increased when Fluspirilene is combined with Methylphenidate.
Metoclopramide The risk or severity of adverse effects can be increased when Metoclopramide is combined with Fluspirilene.
Metyrosine Fluspirilene may increase the sedative activities of Metyrosine.
Quinagolide The therapeutic efficacy of Quinagolide can be decreased when used in combination with Fluspirilene.
Sulpiride Fluspirilene may increase the antipsychotic activities of Sulpiride.
Cimetidine The serum concentration of Fluspirilene can be increased when it is combined with Cimetidine.
Clopidogrel The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Fluspirilene.
Efavirenz The serum concentration of Fluspirilene can be decreased when it is combined with Efavirenz.
Melatonin The therapeutic efficacy of Fluspirilene can be decreased when used in combination with Melatonin.
Nafcillin The therapeutic efficacy of Fluspirilene can be decreased when used in combination with Nafcillin.
Nitroprusside Fluspirilene may increase the hypotensive activities of Nitroprusside.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Fluspirilene.
Mequitazine Fluspirilene may increase the arrhythmogenic activities of Mequitazine.
Dantrolene The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Fluspirilene.
Lithium citrate The risk or severity of adverse effects can be increased when Fluspirilene is combined with Lithium citrate.
Lithium carbonate The risk or severity of adverse effects can be increased when Fluspirilene is combined with Lithium carbonate.
Lithium hydroxide The risk or severity of adverse effects can be increased when Fluspirilene is combined with Lithium hydroxide.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Fluspirilene.
Dicoumarol The risk or severity of adverse effects can be increased when Fluspirilene is combined with Dicoumarol.
Phenindione The risk or severity of adverse effects can be increased when Fluspirilene is combined with Phenindione.
Coumarin The risk or severity of adverse effects can be increased when Fluspirilene is combined with Coumarin.
Tioclomarol The risk or severity of adverse effects can be increased when Fluspirilene is combined with Tioclomarol.
Warfarin The risk or severity of adverse effects can be increased when Fluspirilene is combined with Warfarin.
Phenprocoumon The risk or severity of adverse effects can be increased when Fluspirilene is combined with Phenprocoumon.
Acenocoumarol The risk or severity of adverse effects can be increased when Fluspirilene is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Fluspirilene is combined with 4-hydroxycoumarin.
(R)-warfarin The risk or severity of adverse effects can be increased when Fluspirilene is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Fluspirilene is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of adverse effects can be increased when Fluspirilene is combined with Fluindione.
Clorindione The risk or severity of adverse effects can be increased when Fluspirilene is combined with Clorindione.
Diphenadione The risk or severity of adverse effects can be increased when Fluspirilene is combined with Diphenadione.
(S)-Warfarin The risk or severity of adverse effects can be increased when Fluspirilene is combined with (S)-Warfarin.
Mirtazapine Fluspirilene may increase the serotonergic activities of Mirtazapine.
Ethanol Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Zimelidine The risk or severity of adverse effects can be increased when Fluspirilene is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Fluspirilene is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Fluspirilene is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Fluspirilene is combined with Fluvoxamine.
Duloxetine The risk or severity of adverse effects can be increased when Fluspirilene is combined with Duloxetine.
Paroxetine The risk or severity of adverse effects can be increased when Fluspirilene is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Fluspirilene is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Fluspirilene is combined with Sibutramine.
Milnacipran The risk or severity of adverse effects can be increased when Fluspirilene is combined with Milnacipran.
Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Fluspirilene.
Levomilnacipran The risk or severity of serotonin syndrome can be increased when Fluspirilene is combined with Levomilnacipran.
Indalpine The risk or severity of adverse effects can be increased when Fluspirilene is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Fluspirilene is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Fluspirilene is combined with Alaproclate.
Tocainide Tocainide may increase the arrhythmogenic activities of Fluspirilene.
Aprindine Aprindine may increase the arrhythmogenic activities of Fluspirilene.
Carteolol Fluspirilene may increase the arrhythmogenic activities of Carteolol.
Metipranolol Fluspirilene may increase the arrhythmogenic activities of Metipranolol.
Xylometazoline Fluspirilene may increase the arrhythmogenic activities of Xylometazoline.
Sparteine Fluspirilene may increase the arrhythmogenic activities of Sparteine.
Fasudil Fluspirilene may increase the arrhythmogenic activities of Fasudil.
Spiradoline Fluspirilene may increase the arrhythmogenic activities of Spiradoline.
Tiracizine Fluspirilene may increase the arrhythmogenic activities of Tiracizine.
Ethacizine Fluspirilene may increase the arrhythmogenic activities of Ethacizine.
Hydroquinine Fluspirilene may increase the arrhythmogenic activities of Hydroquinine.
Bioallethrin Fluspirilene may increase the arrhythmogenic activities of Bioallethrin.
Fosfructose Fluspirilene may increase the arrhythmogenic activities of Fosfructose.
Hydroquinidine Fluspirilene may increase the arrhythmogenic activities of Hydroquinidine.
SOR-C13 Fluspirilene may increase the arrhythmogenic activities of SOR-C13.
Digoxin Digoxin may increase the arrhythmogenic activities of Fluspirilene.
Acetyldigitoxin Acetyldigitoxin may increase the arrhythmogenic activities of Fluspirilene.
Deslanoside Deslanoside may increase the arrhythmogenic activities of Fluspirilene.
Cymarin Fluspirilene may increase the arrhythmogenic activities of Cymarin.
Metildigoxin Fluspirilene may increase the arrhythmogenic activities of Metildigoxin.
Acetyldigoxin Fluspirilene may increase the arrhythmogenic activities of Acetyldigoxin.
Disopyramide Disopyramide may increase the arrhythmogenic activities of Fluspirilene.
Ibutilide Ibutilide may increase the arrhythmogenic activities of Fluspirilene.
Procainamide Procainamide may increase the arrhythmogenic activities of Fluspirilene.
Bepridil Bepridil may increase the arrhythmogenic activities of Fluspirilene.
Terodiline Fluspirilene may increase the arrhythmogenic activities of Terodiline.
Diltiazem Diltiazem may increase the arrhythmogenic activities of Fluspirilene.

Target Protein

D(2) dopamine receptor DRD2
5-hydroxytryptamine receptor 2A HTR2A
Voltage-dependent calcium channel gamma-1 subunit CACNG1

Referensi & Sumber

Synthesis reference: Janssen, P.A.J.; U.S. Patent 3,238,216; March 1, 1966; assigned to Research Laboratorium Dr. C. Janssen NV, Belgium.

Contoh Produk & Brand

Produk: 2 • International brands: 3
Produk
  • Imap Forte Inj 10mg/ml
    Suspension • 10 mg / mL • Intramuscular • Canada • Approved
  • Imap Inj 2mg/ml
    Suspension • 2 mg / mL • Intramuscular • Canada • Approved
International Brands
  • Imap — Janssen
  • lmap — McNeil
  • Redeptin — SKF

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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