-Flunarizine should be used with care in patients with depression or those being prescribed other agents, such as phenothiazines, concurrently, which may cause extrapyramidal side-effects.
-Acute overdosage has been reported and the observed symptoms were sedation, agitation and tachycardia.
-Treatment of acute overdosage consists of charcoal administration, induction of emesis or gastric lavage, and supportive measures. No specific antidote is known.
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ceritinib | Flunarizine may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Flunarizine may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Flunarizine. |
| Deferasirox | The serum concentration of Flunarizine can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Flunarizine can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Flunarizine can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Flunarizine can be decreased when it is combined with Teriflunomide. |
| Buprenorphine | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Hydrocodone | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Magnesium sulfate | The therapeutic efficacy of Flunarizine can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Flunarizine may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Mirtazapine | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Orphenadrine | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Pramipexole | Flunarizine may increase the sedative activities of Pramipexole. |
| Ropinirole | Flunarizine may increase the sedative activities of Ropinirole. |
| Rotigotine | Flunarizine may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Flunarizine. |
| Sodium oxybate | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Thalidomide | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Mefloquine | The therapeutic efficacy of Flunarizine can be decreased when used in combination with Mefloquine. |
| Mianserin | The therapeutic efficacy of Flunarizine can be decreased when used in combination with Mianserin. |
| Orlistat | Orlistat can cause a decrease in the absorption of Flunarizine resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Phenytoin | The therapeutic efficacy of Flunarizine can be increased when used in combination with Phenytoin. |
| Fosphenytoin | The therapeutic efficacy of Flunarizine can be increased when used in combination with Fosphenytoin. |
| Topotecan | Flunarizine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
| Cimetidine | The serum concentration of Flunarizine can be increased when it is combined with Cimetidine. |
| Clopidogrel | The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Flunarizine. |
| Efavirenz | The serum concentration of Flunarizine can be decreased when it is combined with Efavirenz. |
| Melatonin | The therapeutic efficacy of Flunarizine can be decreased when used in combination with Melatonin. |
| Nafcillin | The therapeutic efficacy of Flunarizine can be decreased when used in combination with Nafcillin. |
| Nitroprusside | Flunarizine may increase the hypotensive activities of Nitroprusside. |
| Benzylpenicilloyl polylysine | Flunarizine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent. |
| Betahistine | The therapeutic efficacy of Betahistine can be decreased when used in combination with Flunarizine. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Flunarizine. |
| Dantrolene | The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Flunarizine. |
| Lithium citrate | The risk or severity of adverse effects can be increased when Flunarizine is combined with Lithium citrate. |
| Lithium carbonate | The risk or severity of adverse effects can be increased when Flunarizine is combined with Lithium carbonate. |
| Lithium hydroxide | The risk or severity of adverse effects can be increased when Flunarizine is combined with Lithium hydroxide. |
| Carbamazepine | The serum concentration of Flunarizine can be decreased when it is combined with Carbamazepine. |
| Tetracosactide | The risk or severity of liver damage can be increased when Tetracosactide is combined with Flunarizine. |
| Mirabegron | The serum concentration of Flunarizine can be increased when it is combined with Mirabegron. |
| Boceprevir | The serum concentration of Flunarizine can be increased when it is combined with Boceprevir. |
| Abiraterone | The serum concentration of Flunarizine can be increased when it is combined with Abiraterone. |
| Cyproterone acetate | The metabolism of Flunarizine can be increased when combined with Cyproterone acetate. |
| Ethanol | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Flunarizine. |
| Citalopram | The risk or severity of adverse effects can be increased when Flunarizine is combined with Citalopram. |
| Trazodone | The risk or severity of adverse effects can be increased when Flunarizine is combined with Trazodone. |
| Sertraline | The risk or severity of adverse effects can be increased when Flunarizine is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Flunarizine is combined with Sibutramine. |
| Zimelidine | The risk or severity of adverse effects can be increased when Flunarizine is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Flunarizine is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Flunarizine is combined with Milnacipran. |
| Desvenlafaxine | The serum concentration of Flunarizine can be increased when it is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Flunarizine is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Flunarizine is combined with Indalpine. |
| Alaproclate | The risk or severity of adverse effects can be increased when Flunarizine is combined with Alaproclate. |
| Amphetamine | Amphetamine may decrease the sedative activities of Flunarizine. |
| Phentermine | Phentermine may decrease the sedative activities of Flunarizine. |
| Pseudoephedrine | Pseudoephedrine may decrease the sedative activities of Flunarizine. |
| Benzphetamine | Benzphetamine may decrease the sedative activities of Flunarizine. |
| Diethylpropion | Diethylpropion may decrease the sedative activities of Flunarizine. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the sedative activities of Flunarizine. |
| Mephentermine | Mephentermine may decrease the sedative activities of Flunarizine. |
| MMDA | MMDA may decrease the sedative activities of Flunarizine. |
| Midomafetamine | Midomafetamine may decrease the sedative activities of Flunarizine. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Flunarizine. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Flunarizine. |
| Tenamfetamine | Tenamfetamine may decrease the sedative activities of Flunarizine. |
| Chlorphentermine | Chlorphentermine may decrease the sedative activities of Flunarizine. |
| Methylenedioxyethamphetamine | Methylenedioxyethamphetamine may decrease the sedative activities of Flunarizine. |
| Dextroamphetamine | Dextroamphetamine may decrease the sedative activities of Flunarizine. |
| Metamfetamine | Metamfetamine may decrease the sedative activities of Flunarizine. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the sedative activities of Flunarizine. |
| Ritobegron | Ritobegron may decrease the sedative activities of Flunarizine. |
| Mephedrone | Mephedrone may decrease the sedative activities of Flunarizine. |
| Methoxyphenamine | Methoxyphenamine may decrease the sedative activities of Flunarizine. |
| Gepefrine | Gepefrine may decrease the sedative activities of Flunarizine. |
| 2,5-Dimethoxy-4-ethylthioamphetamine | 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Flunarizine. |
| Phendimetrazine | Phendimetrazine may decrease the sedative activities of Flunarizine. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Flunarizine. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Flunarizine. |
| Levosimendan | Levosimendan may increase the arrhythmogenic activities of Flunarizine. |
| Ajmaline | Ajmaline may increase the arrhythmogenic activities of Flunarizine. |
| Carteolol | Flunarizine may increase the arrhythmogenic activities of Carteolol. |
| Metipranolol | Flunarizine may increase the arrhythmogenic activities of Metipranolol. |
| Azimilide | Flunarizine may increase the arrhythmogenic activities of Azimilide. |