Acute oral toxicity (LD50): 3950 mg/kg Guinea pig
A direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress and tachycardia. Cyclandelate is not approved for use in the U.S. or Canada, but is approved in various European countries.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ceritinib | Cyclandelate may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Cyclandelate may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Cyclandelate. |
| Cimetidine | The serum concentration of Cyclandelate can be increased when it is combined with Cimetidine. |
| Clopidogrel | The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Cyclandelate. |
| Efavirenz | The serum concentration of Cyclandelate can be decreased when it is combined with Efavirenz. |
| Melatonin | The therapeutic efficacy of Cyclandelate can be decreased when used in combination with Melatonin. |
| Nafcillin | The therapeutic efficacy of Cyclandelate can be decreased when used in combination with Nafcillin. |
| Nitroprusside | Cyclandelate may increase the hypotensive activities of Nitroprusside. |
| Dantrolene | The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Cyclandelate. |
| Lithium citrate | The risk or severity of adverse effects can be increased when Cyclandelate is combined with Lithium citrate. |
| Lithium carbonate | The risk or severity of adverse effects can be increased when Cyclandelate is combined with Lithium carbonate. |
| Lithium hydroxide | The risk or severity of adverse effects can be increased when Cyclandelate is combined with Lithium hydroxide. |
| Boceprevir | The serum concentration of Cyclandelate can be increased when it is combined with Boceprevir. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Cyclandelate. |
| Hyoscyamine | Hyoscyamine may increase the arrhythmogenic activities of Cyclandelate. |
| Atropine | Atropine may increase the arrhythmogenic activities of Cyclandelate. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Cyclandelate. |
| Moricizine | Moricizine may increase the arrhythmogenic activities of Cyclandelate. |
| Levosimendan | Levosimendan may increase the arrhythmogenic activities of Cyclandelate. |
| Procainamide | Procainamide may increase the arrhythmogenic activities of Cyclandelate. |
| Tocainide | Tocainide may increase the arrhythmogenic activities of Cyclandelate. |
| Flecainide | Flecainide may increase the arrhythmogenic activities of Cyclandelate. |
| Encainide | Encainide may increase the arrhythmogenic activities of Cyclandelate. |
| Ajmaline | Ajmaline may increase the arrhythmogenic activities of Cyclandelate. |
| Aprindine | Aprindine may increase the arrhythmogenic activities of Cyclandelate. |
| Carteolol | Cyclandelate may increase the arrhythmogenic activities of Carteolol. |
| Metipranolol | Cyclandelate may increase the arrhythmogenic activities of Metipranolol. |
| Azimilide | Cyclandelate may increase the arrhythmogenic activities of Azimilide. |
| Tedisamil | Cyclandelate may increase the arrhythmogenic activities of Tedisamil. |
| Vernakalant | Cyclandelate may increase the arrhythmogenic activities of Vernakalant. |
| Cariporide | Cyclandelate may increase the arrhythmogenic activities of Cariporide. |
| Xylometazoline | Cyclandelate may increase the arrhythmogenic activities of Xylometazoline. |
| Sparteine | Cyclandelate may increase the arrhythmogenic activities of Sparteine. |
| Fasudil | Cyclandelate may increase the arrhythmogenic activities of Fasudil. |
| Melperone | Cyclandelate may increase the arrhythmogenic activities of Melperone. |
| Tropisetron | Cyclandelate may increase the arrhythmogenic activities of Tropisetron. |
| Simendan | Cyclandelate may increase the arrhythmogenic activities of Simendan. |
| Spiradoline | Cyclandelate may increase the arrhythmogenic activities of Spiradoline. |
| Pilsicainide | Cyclandelate may increase the arrhythmogenic activities of Pilsicainide. |
| Cicletanine | Cyclandelate may increase the arrhythmogenic activities of Cicletanine. |
| Cibenzoline | Cyclandelate may increase the arrhythmogenic activities of Cibenzoline. |
| Nizofenone | Cyclandelate may increase the arrhythmogenic activities of Nizofenone. |
| Prajmaline | Cyclandelate may increase the arrhythmogenic activities of Prajmaline. |
| Tiracizine | Cyclandelate may increase the arrhythmogenic activities of Tiracizine. |
| Ethacizine | Cyclandelate may increase the arrhythmogenic activities of Ethacizine. |
| Lorajmine | Cyclandelate may increase the arrhythmogenic activities of Lorajmine. |
| Bunaftine | Cyclandelate may increase the arrhythmogenic activities of Bunaftine. |
| Lorcainide | Cyclandelate may increase the arrhythmogenic activities of Lorcainide. |
| Hydroquinine | Cyclandelate may increase the arrhythmogenic activities of Hydroquinine. |
| Bioallethrin | Cyclandelate may increase the arrhythmogenic activities of Bioallethrin. |
| Fosfructose | Cyclandelate may increase the arrhythmogenic activities of Fosfructose. |
| Hydroquinidine | Cyclandelate may increase the arrhythmogenic activities of Hydroquinidine. |
| SOR-C13 | Cyclandelate may increase the arrhythmogenic activities of SOR-C13. |
| Digoxin | Digoxin may increase the arrhythmogenic activities of Cyclandelate. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Cyclandelate. |
| Deslanoside | Deslanoside may increase the arrhythmogenic activities of Cyclandelate. |
| Cymarin | Cyclandelate may increase the arrhythmogenic activities of Cymarin. |
| Metildigoxin | Cyclandelate may increase the arrhythmogenic activities of Metildigoxin. |
| Acetyldigoxin | Cyclandelate may increase the arrhythmogenic activities of Acetyldigoxin. |
| Niguldipine | Cyclandelate may increase the arrhythmogenic activities of Niguldipine. |
| Bretylium | Bretylium may increase the arrhythmogenic activities of Cyclandelate. |
| Isradipine | Isradipine may increase the arrhythmogenic activities of Cyclandelate. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Cyclandelate. |
| Trimethadione | Trimethadione may increase the arrhythmogenic activities of Cyclandelate. |
| Amlodipine | Amlodipine may increase the arrhythmogenic activities of Cyclandelate. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Cyclandelate. |
| Lercanidipine | Lercanidipine may increase the arrhythmogenic activities of Cyclandelate. |
| Lamotrigine | Lamotrigine may increase the arrhythmogenic activities of Cyclandelate. |
| Cinnarizine | Cinnarizine may increase the arrhythmogenic activities of Cyclandelate. |
| Nicardipine | Nicardipine may increase the arrhythmogenic activities of Cyclandelate. |
| Verapamil | Verapamil may increase the arrhythmogenic activities of Cyclandelate. |
| Losartan | Losartan may increase the arrhythmogenic activities of Cyclandelate. |
| Levomenthol | Levomenthol may increase the arrhythmogenic activities of Cyclandelate. |
| Zonisamide | Zonisamide may increase the arrhythmogenic activities of Cyclandelate. |
| Nitrendipine | Nitrendipine may increase the arrhythmogenic activities of Cyclandelate. |
| Perhexiline | Perhexiline may increase the arrhythmogenic activities of Cyclandelate. |
| Bepridil | Bepridil may increase the arrhythmogenic activities of Cyclandelate. |
| Nimesulide | Nimesulide may increase the arrhythmogenic activities of Cyclandelate. |
| Prenylamine | Prenylamine may increase the arrhythmogenic activities of Cyclandelate. |
| Flunarizine | Cyclandelate may increase the arrhythmogenic activities of Flunarizine. |
| Fluspirilene | Cyclandelate may increase the arrhythmogenic activities of Fluspirilene. |
| Clevidipine | Cyclandelate may increase the arrhythmogenic activities of Clevidipine. |
| Methsuximide | Cyclandelate may increase the arrhythmogenic activities of Methsuximide. |
| Seletracetam | Cyclandelate may increase the arrhythmogenic activities of Seletracetam. |
| Nylidrin | Cyclandelate may increase the arrhythmogenic activities of Nylidrin. |
| Ziconotide | Cyclandelate may increase the arrhythmogenic activities of Ziconotide. |
| Dotarizine | Cyclandelate may increase the arrhythmogenic activities of Dotarizine. |
| Nilvadipine | Cyclandelate may increase the arrhythmogenic activities of Nilvadipine. |
| Tranilast | Cyclandelate may increase the arrhythmogenic activities of Tranilast. |
| Agmatine | Cyclandelate may increase the arrhythmogenic activities of Agmatine. |
| Fendiline | Cyclandelate may increase the arrhythmogenic activities of Fendiline. |
| Eperisone | Cyclandelate may increase the arrhythmogenic activities of Eperisone. |
| Trimebutine | Cyclandelate may increase the arrhythmogenic activities of Trimebutine. |
| Pinaverium | Cyclandelate may increase the arrhythmogenic activities of Pinaverium. |
| Nicorandil | Cyclandelate may increase the arrhythmogenic activities of Nicorandil. |
| Barnidipine | Cyclandelate may increase the arrhythmogenic activities of Barnidipine. |
| Aranidipine | Cyclandelate may increase the arrhythmogenic activities of Aranidipine. |
| Azelnidipine | Cyclandelate may increase the arrhythmogenic activities of Azelnidipine. |
| Benidipine | Cyclandelate may increase the arrhythmogenic activities of Benidipine. |