Symptoms of overdose include delirium, convulsions, muscle spasms or seizure, cardiac arrest, shortness or loss of breath, vomiting or nausea, and coma or death. The LD50 for mice is 1250 mg/kg and for rats is 326 mg/kg (Strasenburg Labs).
Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, sedative, and muscle relaxant commonly used for insomnia. It has also been used illegally as a recreational drug, commonly known as Quaaludes, Sopors, Ludes or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. Since at least 2001, it has been widely used in South Africa, where it is commonly referred to as "smarties" or "geluk-tablette" (meaning happy tablets). Clandestinely produced methaqualone is still seized by government agencies and police forces around the world.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Hydrocodone | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Magnesium sulfate | The therapeutic efficacy of Methaqualone can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Methaqualone may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Mirtazapine | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Orphenadrine | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Pramipexole | Methaqualone may increase the sedative activities of Pramipexole. |
| Ropinirole | Methaqualone may increase the sedative activities of Ropinirole. |
| Rotigotine | Methaqualone may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Methaqualone. |
| Suvorexant | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Thalidomide | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Methaqualone. |
| Sodium oxybate | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Ethanol | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Fluvoxamine. |
| Citalopram | The risk or severity of adverse effects can be increased when Methaqualone is combined with Citalopram. |
| Duloxetine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Duloxetine. |
| Trazodone | The risk or severity of adverse effects can be increased when Methaqualone is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Paroxetine. |
| Sertraline | The risk or severity of adverse effects can be increased when Methaqualone is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Sibutramine. |
| Escitalopram | The risk or severity of adverse effects can be increased when Methaqualone is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Methaqualone is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Methaqualone is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Methaqualone is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Methaqualone is combined with Alaproclate. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Methaqualone. |
| Amoxapine | The risk or severity of CNS depression can be increased when Amoxapine is combined with Methaqualone. |
| Propiomazine | The risk or severity of CNS depression can be increased when Propiomazine is combined with Methaqualone. |
| Maprotiline | The risk or severity of CNS depression can be increased when Maprotiline is combined with Methaqualone. |
| Desipramine | The risk or severity of CNS depression can be increased when Desipramine is combined with Methaqualone. |
| Pizotifen | The risk or severity of CNS depression can be increased when Methaqualone is combined with Pizotifen. |
| Dosulepin | The risk or severity of CNS depression can be increased when Methaqualone is combined with Dosulepin. |
| Amitriptyline | The risk or severity of CNS depression can be increased when Amitriptyline is combined with Methaqualone. |
| Imipramine | The risk or severity of CNS depression can be increased when Imipramine is combined with Methaqualone. |
| Nortriptyline | The risk or severity of CNS depression can be increased when Nortriptyline is combined with Methaqualone. |
| Nicardipine | The metabolism of Methaqualone can be decreased when combined with Nicardipine. |
| Doxepin | The risk or severity of CNS depression can be increased when Doxepin is combined with Methaqualone. |
| Quetiapine | The risk or severity of CNS depression can be increased when Quetiapine is combined with Methaqualone. |
| Zopiclone | The risk or severity of adverse effects can be increased when Methaqualone is combined with Zopiclone. |
| Botulinum toxin type B | The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Methaqualone. |
| Botulinum toxin type A | The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Methaqualone. |
| Tryptophan | The risk or severity of CNS depression can be increased when Tryptophan is combined with Methaqualone. |
| Baclofen | Baclofen may increase the central nervous system depressant (CNS depressant) activities of Methaqualone. |
| Lorazepam | The risk or severity of CNS depression can be increased when Lorazepam is combined with Methaqualone. |
| Ethchlorvynol | The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Methaqualone. |
| Succinylcholine | The risk or severity of CNS depression can be increased when Succinylcholine is combined with Methaqualone. |
| Reserpine | The risk or severity of CNS depression can be increased when Reserpine is combined with Methaqualone. |
| Enflurane | The risk or severity of CNS depression can be increased when Enflurane is combined with Methaqualone. |
| Temazepam | The risk or severity of CNS depression can be increased when Temazepam is combined with Methaqualone. |
| Reboxetine | The risk or severity of CNS depression can be increased when Reboxetine is combined with Methaqualone. |
| Butabarbital | The risk or severity of CNS depression can be increased when Butabarbital is combined with Methaqualone. |
| Butalbital | The risk or severity of CNS depression can be increased when Butalbital is combined with Methaqualone. |
| Cabergoline | The risk or severity of CNS depression can be increased when Cabergoline is combined with Methaqualone. |
| Topiramate | The risk or severity of CNS depression can be increased when Topiramate is combined with Methaqualone. |
| Clemastine | The risk or severity of CNS depression can be increased when Clemastine is combined with Methaqualone. |
| Venlafaxine | The risk or severity of CNS depression can be increased when Venlafaxine is combined with Methaqualone. |
| Etomidate | The risk or severity of CNS depression can be increased when Etomidate is combined with Methaqualone. |
| Morphine | The risk or severity of CNS depression can be increased when Morphine is combined with Methaqualone. |
| Talbutal | The risk or severity of CNS depression can be increased when Talbutal is combined with Methaqualone. |
| Valproic acid | The risk or severity of CNS depression can be increased when Valproic acid is combined with Methaqualone. |
| Zolmitriptan | The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Methaqualone. |
| Codeine | The risk or severity of CNS depression can be increased when Codeine is combined with Methaqualone. |
| Tolcapone | The risk or severity of CNS depression can be increased when Tolcapone is combined with Methaqualone. |
| Hydromorphone | The risk or severity of CNS depression can be increased when Hydromorphone is combined with Methaqualone. |
| Olanzapine | The risk or severity of CNS depression can be increased when Olanzapine is combined with Methaqualone. |
| Cetirizine | The risk or severity of CNS depression can be increased when Cetirizine is combined with Methaqualone. |
| Protriptyline | The risk or severity of CNS depression can be increased when Protriptyline is combined with Methaqualone. |
| Trimethadione | The risk or severity of CNS depression can be increased when Trimethadione is combined with Methaqualone. |
| Clobazam | The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Methaqualone. |
| Chlorzoxazone | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Methaqualone. |
| Clozapine | The metabolism of Methaqualone can be decreased when combined with Clozapine. |
| Meprobamate | The risk or severity of CNS depression can be increased when Meprobamate is combined with Methaqualone. |
| Thiethylperazine | The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Methaqualone. |
| Palonosetron | The risk or severity of CNS depression can be increased when Palonosetron is combined with Methaqualone. |
| Sulpiride | The risk or severity of CNS depression can be increased when Sulpiride is combined with Methaqualone. |
| Dexbrompheniramine | The risk or severity of CNS depression can be increased when Dexbrompheniramine is combined with Methaqualone. |
| Loxapine | The risk or severity of CNS depression can be increased when Loxapine is combined with Methaqualone. |
| Remoxipride | The risk or severity of CNS depression can be increased when Remoxipride is combined with Methaqualone. |
| Metocurine iodide | The risk or severity of CNS depression can be increased when Metocurine iodide is combined with Methaqualone. |
| Secobarbital | The risk or severity of CNS depression can be increased when Secobarbital is combined with Methaqualone. |
| Promazine | The risk or severity of CNS depression can be increased when Promazine is combined with Methaqualone. |