Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving many organs including skin exanthema, flu-like symptoms, arthralgias, and sometimes eosinophilia. Additionally, zimelidine was charged to cause an increase in suicidal ideation and/or attempts among depressive patients.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Cyproheptadine | The therapeutic efficacy of Zimelidine can be decreased when used in combination with Cyproheptadine. |
| Desmopressin | The risk or severity of hyponatremia can be increased when Zimelidine is combined with Desmopressin. |
| Ioflupane I-123 | Zimelidine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent. |
| Linezolid | The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Zimelidine. |
| Metyrosine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Zimelidine. |
| Pimozide | The risk or severity of QTc prolongation can be increased when Zimelidine is combined with Pimozide. |
| Buprenorphine | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zimelidine. |
| Dronabinol | The serum concentration of Dronabinol can be increased when it is combined with Zimelidine. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Zimelidine. |
| Hydrocodone | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zimelidine. |
| Magnesium sulfate | The therapeutic efficacy of Zimelidine can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zimelidine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zimelidine. |
| Orphenadrine | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zimelidine. |
| Pramipexole | Zimelidine may increase the sedative activities of Pramipexole. |
| Ropinirole | Zimelidine may increase the sedative activities of Ropinirole. |
| Rotigotine | Zimelidine may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Zimelidine. |
| Sodium oxybate | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zimelidine. |
| Thalidomide | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Brexpiprazole | The metabolism of Brexpiprazole can be decreased when combined with Zimelidine. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Zimelidine. |
| Everolimus | The metabolism of Everolimus can be decreased when combined with Zimelidine. |
| Flibanserin | The metabolism of Flibanserin can be decreased when combined with Zimelidine. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Zimelidine. |
| Ivabradine | The metabolism of Ivabradine can be decreased when combined with Zimelidine. |
| Ivacaftor | The metabolism of Ivacaftor can be decreased when combined with Zimelidine. |
| Lurasidone | The metabolism of Lurasidone can be decreased when combined with Zimelidine. |
| Naloxegol | The metabolism of Naloxegol can be decreased when combined with Zimelidine. |
| Olaparib | The metabolism of Olaparib can be decreased when combined with Zimelidine. |
| Ranolazine | The metabolism of Ranolazine can be decreased when combined with Zimelidine. |
| Sonidegib | The metabolism of Sonidegib can be decreased when combined with Zimelidine. |
| Avanafil | The metabolism of Avanafil can be decreased when combined with Zimelidine. |
| Eplerenone | The metabolism of Eplerenone can be decreased when combined with Zimelidine. |
| Cilostazol | The metabolism of Cilostazol can be decreased when combined with Zimelidine. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Zimelidine. |
| Fentanyl | The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Zimelidine. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Zimelidine. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Zimelidine. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Zimelidine. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Zimelidine. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Zimelidine. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Zimelidine. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Zimelidine. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with Zimelidine. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Zimelidine. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with Zimelidine. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with Zimelidine. |
| (R)-warfarin | The serum concentration of (R)-warfarin can be increased when it is combined with Zimelidine. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Zimelidine. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Zimelidine. |
| (S)-Warfarin | The serum concentration of (S)-Warfarin can be increased when it is combined with Zimelidine. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Zimelidine. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Zimelidine. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Zimelidine. |
| Tedizolid phosphate | The risk or severity of serotonin syndrome can be increased when Tedizolid phosphate is combined with Zimelidine. |
| Mirtazapine | Zimelidine may increase the serotonergic activities of Mirtazapine. |
| Morphine | The risk or severity of serotonin syndrome can be increased when Morphine is combined with Zimelidine. |
| Codeine | The risk or severity of serotonin syndrome can be increased when Codeine is combined with Zimelidine. |
| Hydromorphone | The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Zimelidine. |
| Oxycodone | The risk or severity of serotonin syndrome can be increased when Oxycodone is combined with Zimelidine. |
| Butorphanol | The risk or severity of serotonin syndrome can be increased when Butorphanol is combined with Zimelidine. |
| Dextropropoxyphene | The risk or severity of serotonin syndrome can be increased when Dextropropoxyphene is combined with Zimelidine. |
| Pentazocine | The risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Zimelidine. |
| Sufentanil | The risk or severity of serotonin syndrome can be increased when Sufentanil is combined with Zimelidine. |
| Nalbuphine | The risk or severity of serotonin syndrome can be increased when Nalbuphine is combined with Zimelidine. |
| Levorphanol | The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Zimelidine. |
| Remifentanil | The risk or severity of serotonin syndrome can be increased when Remifentanil is combined with Zimelidine. |
| Diphenoxylate | The risk or severity of serotonin syndrome can be increased when Diphenoxylate is combined with Zimelidine. |
| Oxymorphone | The risk or severity of serotonin syndrome can be increased when Oxymorphone is combined with Zimelidine. |
| Dezocine | The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Zimelidine. |
| Methadyl acetate | The risk or severity of serotonin syndrome can be increased when Methadyl acetate is combined with Zimelidine. |
| Dihydroetorphine | The risk or severity of serotonin syndrome can be increased when Dihydroetorphine is combined with Zimelidine. |
| Diamorphine | The risk or severity of serotonin syndrome can be increased when Diamorphine is combined with Zimelidine. |
| Ethylmorphine | The risk or severity of serotonin syndrome can be increased when Ethylmorphine is combined with Zimelidine. |
| Etorphine | The risk or severity of serotonin syndrome can be increased when Etorphine is combined with Zimelidine. |
| Dextromoramide | The risk or severity of serotonin syndrome can be increased when Dextromoramide is combined with Zimelidine. |
| Desomorphine | The risk or severity of serotonin syndrome can be increased when Desomorphine is combined with Zimelidine. |
| Carfentanil | The risk or severity of serotonin syndrome can be increased when Carfentanil is combined with Zimelidine. |
| Dihydrocodeine | The risk or severity of serotonin syndrome can be increased when Dihydrocodeine is combined with Zimelidine. |
| Alphacetylmethadol | The risk or severity of serotonin syndrome can be increased when Alphacetylmethadol is combined with Zimelidine. |
| Dihydromorphine | The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Zimelidine. |
| Ketobemidone | The risk or severity of serotonin syndrome can be increased when Ketobemidone is combined with Zimelidine. |
| DPDPE | The risk or severity of serotonin syndrome can be increased when DPDPE is combined with Zimelidine. |
| Lofentanil | The risk or severity of serotonin syndrome can be increased when Lofentanil is combined with Zimelidine. |
| Opium | The risk or severity of serotonin syndrome can be increased when Opium is combined with Zimelidine. |
| Normethadone | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Zimelidine. |
| Piritramide | The risk or severity of serotonin syndrome can be increased when Piritramide is combined with Zimelidine. |
| Alphaprodine | The risk or severity of serotonin syndrome can be increased when Alphaprodine is combined with Zimelidine. |
| Meptazinol | The risk or severity of serotonin syndrome can be increased when Meptazinol is combined with Zimelidine. |
| Phenoperidine | The risk or severity of serotonin syndrome can be increased when Phenoperidine is combined with Zimelidine. |
| Phenazocine | The risk or severity of serotonin syndrome can be increased when Phenazocine is combined with Zimelidine. |