Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier et al., 1982)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Alfuzosin | Alfuzosin may increase the hypotensive activities of Tienilic acid. |
| Amifostine | Tienilic acid may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Tienilic acid. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Tienilic acid. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Tienilic acid. |
| Obinutuzumab | Tienilic acid may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Tienilic acid. |
| Rituximab | Tienilic acid may increase the hypotensive activities of Rituximab. |
| Cyclosporine | Cyclosporine may decrease the antihypertensive activities of Tienilic acid. |
| Phentermine | Phentermine may decrease the antihypertensive activities of Tienilic acid. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Tienilic acid. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Tienilic acid. |
| Methysergide | Methysergide may decrease the antihypertensive activities of Tienilic acid. |
| Cabergoline | Cabergoline may decrease the antihypertensive activities of Tienilic acid. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Tienilic acid. |
| Dihydroergotamine | Dihydroergotamine may decrease the antihypertensive activities of Tienilic acid. |
| Protriptyline | Protriptyline may decrease the antihypertensive activities of Tienilic acid. |
| Methylergometrine | Methylergometrine may decrease the antihypertensive activities of Tienilic acid. |
| Mirtazapine | Mirtazapine may decrease the antihypertensive activities of Tienilic acid. |
| Phenylephrine | Phenylephrine may decrease the antihypertensive activities of Tienilic acid. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Tienilic acid. |
| Droperidol | Droperidol may decrease the antihypertensive activities of Tienilic acid. |
| Nortriptyline | Nortriptyline may decrease the antihypertensive activities of Tienilic acid. |
| Amoxapine | Amoxapine may decrease the antihypertensive activities of Tienilic acid. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Tienilic acid. |
| Atropine | Atropine may decrease the antihypertensive activities of Tienilic acid. |
| Lisuride | Lisuride may decrease the antihypertensive activities of Tienilic acid. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Tienilic acid. |
| Trazodone | Trazodone may decrease the antihypertensive activities of Tienilic acid. |
| Ergotamine | Ergotamine may decrease the antihypertensive activities of Tienilic acid. |
| Nicergoline | Nicergoline may decrease the antihypertensive activities of Tienilic acid. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Tienilic acid. |
| Risperidone | Risperidone may decrease the antihypertensive activities of Tienilic acid. |
| Propiomazine | Propiomazine may decrease the antihypertensive activities of Tienilic acid. |
| Orciprenaline | Orciprenaline may decrease the antihypertensive activities of Tienilic acid. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Tienilic acid. |
| Trifluoperazine | Trifluoperazine may decrease the antihypertensive activities of Tienilic acid. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Tienilic acid. |
| Benzphetamine | Benzphetamine may decrease the antihypertensive activities of Tienilic acid. |
| Ritodrine | Ritodrine may decrease the antihypertensive activities of Tienilic acid. |
| Flupentixol | Flupentixol may decrease the antihypertensive activities of Tienilic acid. |
| Bitolterol | Bitolterol may decrease the antihypertensive activities of Tienilic acid. |
| Diethylpropion | Diethylpropion may decrease the antihypertensive activities of Tienilic acid. |
| Salmeterol | Salmeterol may decrease the antihypertensive activities of Tienilic acid. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Tienilic acid. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Tienilic acid. |
| Ergoloid mesylate | Ergoloid mesylate may decrease the antihypertensive activities of Tienilic acid. |
| Isoprenaline | Isoprenaline may decrease the antihypertensive activities of Tienilic acid. |
| Arbutamine | Arbutamine may decrease the antihypertensive activities of Tienilic acid. |
| Dutasteride | Dutasteride may decrease the antihypertensive activities of Tienilic acid. |
| Propafenone | Propafenone may decrease the antihypertensive activities of Tienilic acid. |
| Pergolide | Pergolide may decrease the antihypertensive activities of Tienilic acid. |
| Finasteride | Finasteride may decrease the antihypertensive activities of Tienilic acid. |
| Ergometrine | Ergometrine may decrease the antihypertensive activities of Tienilic acid. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the antihypertensive activities of Tienilic acid. |
| Fenoterol | Fenoterol may decrease the antihypertensive activities of Tienilic acid. |
| Pirbuterol | Pirbuterol may decrease the antihypertensive activities of Tienilic acid. |
| Ephedra sinica root | Ephedra sinica root may decrease the antihypertensive activities of Tienilic acid. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Tienilic acid. |
| Procaterol | Procaterol may decrease the antihypertensive activities of Tienilic acid. |
| Yohimbine | Yohimbine may decrease the antihypertensive activities of Tienilic acid. |
| Methotrimeprazine | Methotrimeprazine may decrease the antihypertensive activities of Tienilic acid. |
| Clenbuterol | Clenbuterol may decrease the antihypertensive activities of Tienilic acid. |
| Bambuterol | Bambuterol may decrease the antihypertensive activities of Tienilic acid. |
| MMDA | MMDA may decrease the antihypertensive activities of Tienilic acid. |
| Midomafetamine | Midomafetamine may decrease the antihypertensive activities of Tienilic acid. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Tienilic acid. |
| 4-Methoxyamphetamine | 4-Methoxyamphetamine may decrease the antihypertensive activities of Tienilic acid. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Tienilic acid. |
| Tenamfetamine | Tenamfetamine may decrease the antihypertensive activities of Tienilic acid. |
| Chlorphentermine | Chlorphentermine may decrease the antihypertensive activities of Tienilic acid. |
| Dextroamphetamine | Dextroamphetamine may decrease the antihypertensive activities of Tienilic acid. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Tienilic acid. |
| Solifenacin | Solifenacin may decrease the antihypertensive activities of Tienilic acid. |
| Periciazine | Periciazine may decrease the antihypertensive activities of Tienilic acid. |
| Acepromazine | Acepromazine may decrease the antihypertensive activities of Tienilic acid. |
| Thioproperazine | Thioproperazine may decrease the antihypertensive activities of Tienilic acid. |
| Zuclopenthixol | Zuclopenthixol may decrease the antihypertensive activities of Tienilic acid. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Tienilic acid. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Tienilic acid. |
| Lysergic acid diethylamide | Lysergic acid diethylamide may decrease the antihypertensive activities of Tienilic acid. |
| Amineptine | Amineptine may decrease the antihypertensive activities of Tienilic acid. |
| Dronedarone | Dronedarone may decrease the antihypertensive activities of Tienilic acid. |
| Flibanserin | Flibanserin may decrease the antihypertensive activities of Tienilic acid. |
| Iloperidone | Iloperidone may decrease the antihypertensive activities of Tienilic acid. |
| Indacaterol | Indacaterol may decrease the antihypertensive activities of Tienilic acid. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Tienilic acid. |
| Naluzotan | Naluzotan may decrease the antihypertensive activities of Tienilic acid. |
| Cariprazine | Cariprazine may decrease the antihypertensive activities of Tienilic acid. |
| Mianserin | Mianserin may decrease the antihypertensive activities of Tienilic acid. |
| Nylidrin | Nylidrin may decrease the antihypertensive activities of Tienilic acid. |
| Pizotifen | Pizotifen may decrease the antihypertensive activities of Tienilic acid. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Tienilic acid. |
| Asenapine | Asenapine may decrease the antihypertensive activities of Tienilic acid. |
| Esmirtazapine | Esmirtazapine may decrease the antihypertensive activities of Tienilic acid. |
| Vilazodone | Vilazodone may decrease the antihypertensive activities of Tienilic acid. |
| Nitrous oxide | Nitrous oxide may decrease the antihypertensive activities of Tienilic acid. |
| Xylometazoline | Xylometazoline may decrease the antihypertensive activities of Tienilic acid. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Tienilic acid. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Tienilic acid. |