Benoxaprofen

DB04812

small molecule approved withdrawn

Deskripsi

The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets from the market on August 5, 1982.

Struktur Molekul 2D

Berat 301.724
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1386 Data
Amlodipine Benoxaprofen may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Benoxaprofen.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Benoxaprofen.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Benoxaprofen.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Benoxaprofen.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Benoxaprofen.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Benoxaprofen.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Benoxaprofen.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Benoxaprofen.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Benoxaprofen.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Benoxaprofen.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Benoxaprofen.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Benoxaprofen.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Benoxaprofen.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Benoxaprofen.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Benoxaprofen.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Benoxaprofen.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Benoxaprofen.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Benoxaprofen.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Benoxaprofen.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Benoxaprofen.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Benoxaprofen.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Benoxaprofen.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Benoxaprofen.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Benoxaprofen.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Benoxaprofen.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Benoxaprofen.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Benoxaprofen.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Benoxaprofen.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Benoxaprofen.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Benoxaprofen.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Benoxaprofen.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Benoxaprofen.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Benoxaprofen.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Benoxaprofen.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Benoxaprofen.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Benoxaprofen.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Benoxaprofen.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Benoxaprofen.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Benoxaprofen.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Benoxaprofen.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Benoxaprofen.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Benoxaprofen.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Benoxaprofen.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Benoxaprofen.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Benoxaprofen.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Benoxaprofen.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Benoxaprofen.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Benoxaprofen.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Benoxaprofen.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Benoxaprofen.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Benoxaprofen.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Benoxaprofen.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Benoxaprofen.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Benoxaprofen.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Benoxaprofen.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Benoxaprofen.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Benoxaprofen.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Benoxaprofen.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Benoxaprofen.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Benoxaprofen.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Benoxaprofen.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Benoxaprofen.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Benoxaprofen.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Benoxaprofen.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Benoxaprofen.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Benoxaprofen.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Benoxaprofen.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Benoxaprofen.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Benoxaprofen.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Benoxaprofen.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Benoxaprofen.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Benoxaprofen.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Benoxaprofen.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Benoxaprofen.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Benoxaprofen.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Benoxaprofen.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Benoxaprofen.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Benoxaprofen.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Benoxaprofen.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Benoxaprofen.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Benoxaprofen.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Benoxaprofen.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Benoxaprofen.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Benoxaprofen.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Benoxaprofen.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Benoxaprofen.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Benoxaprofen.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Benoxaprofen.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Benoxaprofen.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Benoxaprofen.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Benoxaprofen.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Benoxaprofen.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Benoxaprofen.
Iproniazid The risk or severity of hypertension can be increased when Benoxaprofen is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Benoxaprofen is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Benoxaprofen is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Benoxaprofen is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Benoxaprofen is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Benoxaprofen is combined with Iloperidone.

Target Protein

Acetyl-CoA acetyltransferase, mitochondrial ACAT1

Referensi & Sumber

Synthesis reference: Evans, D., Dunwell, D.W. and Hicks, A.; US. Patent 3,912, 18; October 14, 1975; assigned to Lilly Industries Ltd. Evans, D., Dunwell, D.W. and Hicks, T.A.; U.S. Patent 3,962,441; June 8, 1976; assigned to Lilly Industries, Ltd. Evans, D., Dunwell, D.W. and Hicks, T.A.; US. Patent 3,962,452; June 8, 1976; assigned to Lilly Industries, Ltd.

Contoh Produk & Brand

Produk: 0 • International brands: 4
International Brands
  • Coxigon — Lilly
  • Inflamid — Lilly
  • Opren — Lilly
  • Oraflex — Lilly

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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