Inecalcitol

DB04796

small molecule investigational

Deskripsi

Struktur Molekul 2D

Berat 400.603
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

157 Data
Aluminum hydroxide The serum concentration of Aluminum hydroxide can be increased when it is combined with Inecalcitol.
Danazol Danazol may increase the hypercalcemic activities of Inecalcitol.
Sucralfate The serum concentration of Sucralfate can be increased when it is combined with Inecalcitol.
Orlistat Orlistat can cause a decrease in the absorption of Inecalcitol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium sulfate The serum concentration of Magnesium sulfate can be increased when it is combined with Inecalcitol.
Magnesium oxide The serum concentration of Magnesium oxide can be increased when it is combined with Inecalcitol.
Magnesium salicylate The serum concentration of Magnesium salicylate can be increased when it is combined with Inecalcitol.
Magaldrate The serum concentration of Magaldrate can be increased when it is combined with Inecalcitol.
Magnesium hydroxide The serum concentration of Magnesium hydroxide can be increased when it is combined with Inecalcitol.
Magnesium trisilicate The serum concentration of Magnesium trisilicate can be increased when it is combined with Inecalcitol.
Magnesium chloride The serum concentration of Magnesium chloride can be increased when it is combined with Inecalcitol.
Magnesium carbonate The serum concentration of Magnesium carbonate can be increased when it is combined with Inecalcitol.
Talc The serum concentration of Talc can be increased when it is combined with Inecalcitol.
Magnesium citrate The serum concentration of Magnesium citrate can be increased when it is combined with Inecalcitol.
Magnesium silicate The serum concentration of Magnesium silicate can be increased when it is combined with Inecalcitol.
Hydrotalcite The serum concentration of Hydrotalcite can be increased when it is combined with Inecalcitol.
Magnesium aspartate The serum concentration of Magnesium aspartate can be increased when it is combined with Inecalcitol.
Magnesium peroxide The serum concentration of Magnesium peroxide can be increased when it is combined with Inecalcitol.
Magnesium gluconate The serum concentration of Magnesium gluconate can be increased when it is combined with Inecalcitol.
Magnesium orotate The serum concentration of Magnesium orotate can be increased when it is combined with Inecalcitol.
Magnesium The serum concentration of Magnesium can be increased when it is combined with Inecalcitol.
Magnesium levulinate The serum concentration of Magnesium levulinate can be increased when it is combined with Inecalcitol.
Magnesium lactate The serum concentration of Magnesium lactate can be increased when it is combined with Inecalcitol.
Digoxin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Digoxin.
Acetyldigitoxin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Acetyldigitoxin.
Deslanoside The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Deslanoside.
Ouabain The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Ouabain.
Digitoxin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Digitoxin.
Oleandrin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Oleandrin.
Cymarin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Cymarin.
Proscillaridin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Proscillaridin.
Metildigoxin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Metildigoxin.
Lanatoside C The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Lanatoside C.
Gitoformate The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Gitoformate.
Acetyldigoxin The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Acetyldigoxin.
Peruvoside The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Peruvoside.
Mineral oil Mineral oil can cause a decrease in the absorption of Inecalcitol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methyclothiazide The risk or severity of hypercalcemia can be increased when Methyclothiazide is combined with Inecalcitol.
Bendroflumethiazide The risk or severity of hypercalcemia can be increased when Bendroflumethiazide is combined with Inecalcitol.
Benzthiazide The risk or severity of hypercalcemia can be increased when Benzthiazide is combined with Inecalcitol.
Cyclothiazide The risk or severity of hypercalcemia can be increased when Cyclothiazide is combined with Inecalcitol.
Hydroflumethiazide The risk or severity of hypercalcemia can be increased when Hydroflumethiazide is combined with Inecalcitol.
Chlorothiazide The risk or severity of hypercalcemia can be increased when Chlorothiazide is combined with Inecalcitol.
Hydrochlorothiazide The risk or severity of hypercalcemia can be increased when Hydrochlorothiazide is combined with Inecalcitol.
Trichlormethiazide The risk or severity of hypercalcemia can be increased when Trichlormethiazide is combined with Inecalcitol.
Polythiazide The risk or severity of hypercalcemia can be increased when Polythiazide is combined with Inecalcitol.
Mebutizide The risk or severity of hypercalcemia can be increased when Mebutizide is combined with Inecalcitol.
Cyclopenthiazide The risk or severity of hypercalcemia can be increased when Cyclopenthiazide is combined with Inecalcitol.
Buthiazide The risk or severity of hypercalcemia can be increased when Buthiazide is combined with Inecalcitol.
Calcitriol The risk or severity of adverse effects can be increased when Calcitriol is combined with Inecalcitol.
Calcifediol The risk or severity of adverse effects can be increased when Calcifediol is combined with Inecalcitol.
Ergocalciferol The risk or severity of adverse effects can be increased when Ergocalciferol is combined with Inecalcitol.
Cholecalciferol The risk or severity of adverse effects can be increased when Cholecalciferol is combined with Inecalcitol.
Paricalcitol The risk or severity of adverse effects can be increased when Paricalcitol is combined with Inecalcitol.
Dihydrotachysterol The risk or severity of adverse effects can be increased when Dihydrotachysterol is combined with Inecalcitol.
Alfacalcidol The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Inecalcitol.
Seocalcitol The risk or severity of adverse effects can be increased when Seocalcitol is combined with Inecalcitol.
Becocalcidiol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Becocalcidiol.
Eldecalcitol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Eldecalcitol.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of adverse effects can be increased when Inecalcitol is combined with 1alpha,24S-Dihydroxyvitamin D2.
Elocalcitol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Elocalcitol.
Maxacalcitol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Maxacalcitol.
Doxercalciferol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Doxercalciferol.
Vitamin D The risk or severity of adverse effects can be increased when Inecalcitol is combined with Vitamin D.
1alpha-Hydroxyvitamin D5 The risk or severity of adverse effects can be increased when Inecalcitol is combined with 1alpha-Hydroxyvitamin D5.
Previtamin D(3) The risk or severity of adverse effects can be increased when Inecalcitol is combined with Previtamin D(3).
Calcium acetate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium acetate.
Calcium glucoheptonate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium glucoheptonate.
Calcium chloride The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium chloride.
Calcium The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium.
Calcium carbonate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium carbonate.
Calcium citrate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium citrate.
Calcium gluconate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium gluconate.
Calcium Phosphate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium Phosphate.
Calcium glubionate anhydrous The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium glubionate anhydrous.
Calcium lactate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium lactate.
Calcium lactate gluconate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium lactate gluconate.
Calcium pangamate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium pangamate.
Calcium levulinate The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium levulinate.
Calcium cation The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium cation.
Calcium polycarbophil The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium polycarbophil.
Colestipol The serum concentration of Inecalcitol can be decreased when it is combined with Colestipol.
Sevelamer The serum concentration of Inecalcitol can be decreased when it is combined with Sevelamer.
Colesevelam The serum concentration of Inecalcitol can be decreased when it is combined with Colesevelam.
Cholestyramine The serum concentration of Inecalcitol can be decreased when it is combined with Cholestyramine.
Flunisolide The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Flunisolide.
Beclomethasone dipropionate The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Beclomethasone dipropionate.
Betamethasone The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Betamethasone.
Fluticasone propionate The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Fluticasone propionate.
Fluocinolone acetonide The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Fluocinolone acetonide.
Triamcinolone The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Triamcinolone.
Prednisone The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Prednisone.
Fludrocortisone The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Fludrocortisone.
Hydrocortisone The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Hydrocortisone.
Prednisolone The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Prednisolone.
Methylprednisolone The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Methylprednisolone.
Trilostane The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Trilostane.
Budesonide The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Budesonide.
Dexamethasone The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Dexamethasone.
Corticotropin The therapeutic efficacy of Inecalcitol can be decreased when used in combination with Corticotropin.

Target Protein

Vitamin D3 receptor VDR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18487433
    Wong MS, Delansorne R, Man RY, Vanhoutte PM: Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H289-96. doi: 10.1152/ajpheart.00116.2008. Epub 2008 May 16.
  • PMID: 16039117
    Eelen G, Verlinden L, Van Camp M, Claessens F, De Clercq P, Vandewalle M, Bouillon R, Verstuyf A: Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):65-8. Epub 2005 Jul 20.
Link

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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