Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Apixaban | The risk or severity of adverse effects can be increased when Nimesulide is combined with Apixaban. |
| Dasatinib | Dasatinib may increase the anticoagulant activities of Nimesulide. |
| Ursodeoxycholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Ursodeoxycholic acid. |
| Glycochenodeoxycholic Acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Glycochenodeoxycholic Acid. |
| Cholic Acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Cholic Acid. |
| Glycocholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Glycocholic acid. |
| Deoxycholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Deoxycholic acid. |
| Taurocholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Taurocholic acid. |
| Obeticholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Obeticholic acid. |
| Chenodeoxycholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Chenodeoxycholic acid. |
| Taurochenodeoxycholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Taurochenodeoxycholic acid. |
| Tauroursodeoxycholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Tauroursodeoxycholic acid. |
| Bamet-UD2 | The risk or severity of adverse effects can be increased when Nimesulide is combined with Bamet-UD2. |
| Dehydrocholic acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Dehydrocholic acid. |
| Hyodeoxycholic Acid | The risk or severity of adverse effects can be increased when Nimesulide is combined with Hyodeoxycholic Acid. |
| Glucosamine | Glucosamine may increase the antiplatelet activities of Nimesulide. |
| Ibritumomab tiuxetan | The risk or severity of adverse effects can be increased when Nimesulide is combined with Ibritumomab tiuxetan. |
| Ibrutinib | The risk or severity of adverse effects can be increased when Ibrutinib is combined with Nimesulide. |
| Obinutuzumab | The risk or severity of adverse effects can be increased when Nimesulide is combined with Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the antiplatelet activities of Nimesulide. |
| Rivaroxaban | Nimesulide may increase the anticoagulant activities of Rivaroxaban. |
| Tipranavir | Tipranavir may increase the antiplatelet activities of Nimesulide. |
| Urokinase | Nimesulide may increase the anticoagulant activities of Urokinase. |
| Vitamin E | Vitamin E may increase the antiplatelet activities of Nimesulide. |
| Ceritinib | Nimesulide may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Nimesulide may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Nimesulide. |
| Isoetharine | The risk or severity of hypertension can be increased when Isoetharine is combined with Nimesulide. |
| Zolmitriptan | The risk or severity of hypertension can be increased when Zolmitriptan is combined with Nimesulide. |
| Norepinephrine | The risk or severity of hypertension can be increased when Norepinephrine is combined with Nimesulide. |
| Phenylpropanolamine | The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Nimesulide. |
| Doxapram | The risk or severity of hypertension can be increased when Doxapram is combined with Nimesulide. |
| Metaraminol | The risk or severity of hypertension can be increased when Metaraminol is combined with Nimesulide. |
| Methoxamine | The risk or severity of hypertension can be increased when Methoxamine is combined with Nimesulide. |
| Isoflurane | The risk or severity of hypertension can be increased when Isoflurane is combined with Nimesulide. |
| Orciprenaline | The risk or severity of hypertension can be increased when Orciprenaline is combined with Nimesulide. |
| Propofol | The risk or severity of hypertension can be increased when Propofol is combined with Nimesulide. |
| Phenmetrazine | The risk or severity of hypertension can be increased when Phenmetrazine is combined with Nimesulide. |
| Pseudoephedrine | The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Nimesulide. |
| Ritodrine | The risk or severity of hypertension can be increased when Ritodrine is combined with Nimesulide. |
| Bitolterol | The risk or severity of hypertension can be increased when Bitolterol is combined with Nimesulide. |
| Oxymetazoline | The risk or severity of hypertension can be increased when Oxymetazoline is combined with Nimesulide. |
| Diethylpropion | The risk or severity of hypertension can be increased when Diethylpropion is combined with Nimesulide. |
| Naratriptan | The risk or severity of hypertension can be increased when Naratriptan is combined with Nimesulide. |
| Formoterol | The risk or severity of hypertension can be increased when Formoterol is combined with Nimesulide. |
| Frovatriptan | The risk or severity of hypertension can be increased when Frovatriptan is combined with Nimesulide. |
| Isoprenaline | The risk or severity of hypertension can be increased when Isoprenaline is combined with Nimesulide. |
| Arbutamine | The risk or severity of hypertension can be increased when Arbutamine is combined with Nimesulide. |
| Desflurane | The risk or severity of hypertension can be increased when Desflurane is combined with Nimesulide. |
| Lisdexamfetamine | The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Nimesulide. |
| Fenoterol | The risk or severity of hypertension can be increased when Fenoterol is combined with Nimesulide. |
| Pirbuterol | The risk or severity of hypertension can be increased when Pirbuterol is combined with Nimesulide. |
| Ephedra sinica root | The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Nimesulide. |
| Ephedrine | The risk or severity of hypertension can be increased when Ephedrine is combined with Nimesulide. |
| Mephentermine | The risk or severity of hypertension can be increased when Mephentermine is combined with Nimesulide. |
| Procaterol | The risk or severity of hypertension can be increased when Procaterol is combined with Nimesulide. |
| Clenbuterol | The risk or severity of hypertension can be increased when Clenbuterol is combined with Nimesulide. |
| Bambuterol | The risk or severity of hypertension can be increased when Bambuterol is combined with Nimesulide. |
| MMDA | The risk or severity of hypertension can be increased when MMDA is combined with Nimesulide. |
| Midomafetamine | The risk or severity of hypertension can be increased when Midomafetamine is combined with Nimesulide. |
| 2,5-Dimethoxy-4-ethylamphetamine | The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Nimesulide. |
| 4-Methoxyamphetamine | The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Nimesulide. |
| 4-Bromo-2,5-dimethoxyamphetamine | The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Nimesulide. |
| Tenamfetamine | The risk or severity of hypertension can be increased when Tenamfetamine is combined with Nimesulide. |
| Chlorphentermine | The risk or severity of hypertension can be increased when Chlorphentermine is combined with Nimesulide. |
| Dextroamphetamine | The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Nimesulide. |
| Phendimetrazine | The risk or severity of hypertension can be increased when Phendimetrazine is combined with Nimesulide. |
| Epicaptopril | The risk or severity of hypertension can be increased when Epicaptopril is combined with Nimesulide. |
| 1-benzylimidazole | The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Nimesulide. |
| Amibegron | The risk or severity of hypertension can be increased when Nimesulide is combined with Amibegron. |
| Naluzotan | The risk or severity of hypertension can be increased when Nimesulide is combined with Naluzotan. |
| Solabegron | The risk or severity of hypertension can be increased when Nimesulide is combined with Solabegron. |
| Esmirtazapine | The risk or severity of hypertension can be increased when Nimesulide is combined with Esmirtazapine. |
| Nitrous oxide | The risk or severity of hypertension can be increased when Nimesulide is combined with Nitrous oxide. |
| Dexmethylphenidate | The risk or severity of hypertension can be increased when Nimesulide is combined with Dexmethylphenidate. |
| Isometheptene | The risk or severity of hypertension can be increased when Nimesulide is combined with Isometheptene. |
| Levonordefrin | The risk or severity of hypertension can be increased when Nimesulide is combined with Levonordefrin. |
| Naphazoline | The risk or severity of hypertension can be increased when Nimesulide is combined with Naphazoline. |
| Tetryzoline | The risk or severity of hypertension can be increased when Nimesulide is combined with Tetryzoline. |
| Cinitapride | The risk or severity of hypertension can be increased when Nimesulide is combined with Cinitapride. |
| Tyramine | The risk or severity of hypertension can be increased when Nimesulide is combined with Tyramine. |
| Adrafinil | The risk or severity of hypertension can be increased when Nimesulide is combined with Adrafinil. |
| Isoxsuprine | The risk or severity of hypertension can be increased when Nimesulide is combined with Isoxsuprine. |
| Ifenprodil | The risk or severity of hypertension can be increased when Nimesulide is combined with Ifenprodil. |
| Hexoprenaline | The risk or severity of hypertension can be increased when Nimesulide is combined with Hexoprenaline. |
| Etilefrine | The risk or severity of hypertension can be increased when Nimesulide is combined with Etilefrine. |
| Olodaterol | The risk or severity of hypertension can be increased when Nimesulide is combined with Olodaterol. |
| Cirazoline | The risk or severity of hypertension can be increased when Nimesulide is combined with Cirazoline. |
| Synephrine | The risk or severity of hypertension can be increased when Nimesulide is combined with Synephrine. |
| Doxofylline | The risk or severity of hypertension can be increased when Nimesulide is combined with Doxofylline. |
| Iofetamine I-123 | The risk or severity of hypertension can be increased when Nimesulide is combined with Iofetamine I-123. |
| Racepinephrine | The risk or severity of hypertension can be increased when Nimesulide is combined with Racepinephrine. |
| Amitraz | The risk or severity of hypertension can be increased when Nimesulide is combined with Amitraz. |
| Medetomidine | The risk or severity of hypertension can be increased when Nimesulide is combined with Medetomidine. |
| Xylazine | The risk or severity of hypertension can be increased when Nimesulide is combined with Xylazine. |
| Atipamezole | The risk or severity of hypertension can be increased when Nimesulide is combined with Atipamezole. |
| Ractopamine | The risk or severity of hypertension can be increased when Nimesulide is combined with Ractopamine. |
| Romifidine | The risk or severity of hypertension can be increased when Nimesulide is combined with Romifidine. |
| Detomidine | The risk or severity of hypertension can be increased when Nimesulide is combined with Detomidine. |
| Tetrahydrocannabivarin | The risk or severity of hypertension can be increased when Nimesulide is combined with Tetrahydrocannabivarin. |