Acute oral toxicity (LD50) in mouse: 50.1 mg/kg
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Pravastatin | Pravastatin may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Diethylstilbestrol | Diethylstilbestrol may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Estradiol | Estradiol may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Novobiocin | Novobiocin may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Hesperetin | Hesperetin may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Rabeprazole | Rabeprazole may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Dexamethasone | Dexamethasone may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Dasatinib | Dasatinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Topiroxostat | Topiroxostat may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Daidzin | Daidzin may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Fusidic acid | Fusidic acid may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Naringenin | Naringenin may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Vandetanib | Vandetanib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Eltrombopag | Eltrombopag may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Safinamide | Safinamide may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Vismodegib | Vismodegib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Teriflunomide | Teriflunomide may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Dabrafenib | Dabrafenib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Cannabidiol | Cannabidiol may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Palbociclib | Palbociclib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Dasabuvir | Dasabuvir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Dacomitinib | Dacomitinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Glasdegib | Glasdegib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Fostamatinib | Fostamatinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Gilteritinib | Gilteritinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Brigatinib | Brigatinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Estradiol acetate | Estradiol acetate may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Estradiol benzoate | Estradiol benzoate may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Estradiol cypionate | Estradiol cypionate may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Estradiol dienanthate | Estradiol dienanthate may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Estradiol valerate | Estradiol valerate may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Nabiximols | Nabiximols may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Fedratinib | Fedratinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Istradefylline | Istradefylline may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Caffeine | Caffeine may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Vemurafenib | Vemurafenib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Isavuconazole | Isavuconazole may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Cyclosporine | Cyclosporine may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Pantoprazole | Pantoprazole may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Nelfinavir | Nelfinavir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Gefitinib | Gefitinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Beclomethasone dipropionate | Beclomethasone dipropionate may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Progesterone | Progesterone may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Lansoprazole | Lansoprazole may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Ritonavir | Ritonavir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Erlotinib | Erlotinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Imatinib | Imatinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Buprenorphine | Buprenorphine may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Telmisartan | Telmisartan may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Saquinavir | Saquinavir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Sunitinib | Sunitinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Genistein | Genistein may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Quercetin | Quercetin may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Taurocholic acid | Taurocholic acid may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Nilotinib | Nilotinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Elacridar | Elacridar may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Dovitinib | Dovitinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Simeprevir | Simeprevir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Rilpivirine | Rilpivirine may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Regorafenib | Regorafenib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Ponatinib | Ponatinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Afatinib | Afatinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Cobicistat | Cobicistat may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Daclatasvir | Daclatasvir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Rolapitant | Rolapitant may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Paritaprevir | Paritaprevir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Alectinib | Alectinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Venetoclax | Venetoclax may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Velpatasvir | Velpatasvir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Abemaciclib | Abemaciclib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Voxilaprevir | Voxilaprevir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Rucaparib | Rucaparib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Enasidenib | Enasidenib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Pibrentasvir | Pibrentasvir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Glecaprevir | Glecaprevir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Ripretinib | Ripretinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Fostemsavir | Fostemsavir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Pralsetinib | Pralsetinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Clofazimine | Clofazimine may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Dexamethasone acetate | Dexamethasone acetate may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Avanafil | Avanafil may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Tepotinib | Tepotinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Tivozanib | Tivozanib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Osimertinib | Osimertinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Belumosudil | Belumosudil may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Venlafaxine | Venlafaxine may increase the excretion rate of Camptothecin which could result in a lower serum level and potentially a reduction in efficacy. |
| Cholesterol | Cholesterol may increase the excretion rate of Camptothecin which could result in a lower serum level and potentially a reduction in efficacy. |
| Apalutamide | The serum concentration of Camptothecin can be decreased when it is combined with Apalutamide. |
| Lasmiditan | The serum concentration of Camptothecin can be increased when it is combined with Lasmiditan. |
| Darolutamide | The serum concentration of Camptothecin can be increased when it is combined with Darolutamide. |
| Tafamidis | The serum concentration of Camptothecin can be increased when it is combined with Tafamidis. |
| Capmatinib | The serum concentration of Camptothecin can be increased when it is combined with Capmatinib. |
| Febuxostat | The excretion of Camptothecin can be decreased when combined with Febuxostat. |
| Darbepoetin alfa | The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Camptothecin. |
| Erythropoietin | The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Camptothecin. |
| Peginesatide | The risk or severity of Thrombosis can be increased when Peginesatide is combined with Camptothecin. |
| Methoxy polyethylene glycol-epoetin beta | The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Camptothecin. |
| Itraconazole | Itraconazole may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Ledipasvir | Ledipasvir may decrease the excretion rate of Camptothecin which could result in a higher serum level. |