Coumarin

DB04665

small molecule experimental

Deskripsi

Struktur Molekul 2D

Berat 146.1427
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
  • 2. Ensure consistent Vitamin K intake.

Interaksi Obat

1468 Data
Apixaban Apixaban may increase the anticoagulant activities of Coumarin.
Dabigatran etexilate Dabigatran etexilate may increase the anticoagulant activities of Coumarin.
Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Coumarin.
Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Coumarin is combined with Deferasirox.
Ursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Cholic Acid.
Glycocholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Taurocholic acid.
Obeticholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Coumarin is combined with Hyodeoxycholic Acid.
Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Coumarin.
Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Coumarin.
Obinutuzumab The risk or severity of bleeding and hemorrhage can be increased when Coumarin is combined with Obinutuzumab.
Rivaroxaban Coumarin may increase the anticoagulant activities of Rivaroxaban.
Sugammadex The risk or severity of bleeding and hemorrhage can be increased when Coumarin is combined with Sugammadex.
Tibolone Tibolone may increase the anticoagulant activities of Coumarin.
Tipranavir The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Coumarin.
Urokinase Urokinase may increase the anticoagulant activities of Coumarin.
Vitamin E Vitamin E may increase the anticoagulant activities of Coumarin.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Coumarin.
Gemcitabine The therapeutic efficacy of Coumarin can be increased when used in combination with Gemcitabine.
Flunisolide Flunisolide may increase the anticoagulant activities of Coumarin.
Beclomethasone dipropionate Beclomethasone dipropionate may increase the anticoagulant activities of Coumarin.
Betamethasone Betamethasone may increase the anticoagulant activities of Coumarin.
Fluticasone propionate Fluticasone propionate may increase the anticoagulant activities of Coumarin.
Fluocinolone acetonide Fluocinolone acetonide may increase the anticoagulant activities of Coumarin.
Prednisone Prednisone may increase the anticoagulant activities of Coumarin.
Fludrocortisone Fludrocortisone may increase the anticoagulant activities of Coumarin.
Hydrocortisone Hydrocortisone may increase the anticoagulant activities of Coumarin.
Prednisolone Prednisolone may increase the anticoagulant activities of Coumarin.
Methylprednisolone Methylprednisolone may increase the anticoagulant activities of Coumarin.
Trilostane Trilostane may increase the anticoagulant activities of Coumarin.
Budesonide Budesonide may increase the anticoagulant activities of Coumarin.
Dexamethasone Dexamethasone may increase the anticoagulant activities of Coumarin.
Corticotropin Corticotropin may increase the anticoagulant activities of Coumarin.
Cortisone acetate Cortisone acetate may increase the anticoagulant activities of Coumarin.
Paramethasone Paramethasone may increase the anticoagulant activities of Coumarin.
Ciclesonide Ciclesonide may increase the anticoagulant activities of Coumarin.
Aldosterone Aldosterone may increase the anticoagulant activities of Coumarin.
Fluticasone furoate Fluticasone furoate may increase the anticoagulant activities of Coumarin.
Fluprednidene Fluprednidene may increase the anticoagulant activities of Coumarin.
Tixocortol Tixocortol may increase the anticoagulant activities of Coumarin.
Fluprednisolone Fluprednisolone may increase the anticoagulant activities of Coumarin.
Meprednisone Meprednisone may increase the anticoagulant activities of Coumarin.
Dexamethasone isonicotinate Dexamethasone isonicotinate may increase the anticoagulant activities of Coumarin.
Melengestrol Melengestrol may increase the anticoagulant activities of Coumarin.
Deflazacort Deflazacort may increase the anticoagulant activities of Coumarin.
Cortivazol Cortivazol may increase the anticoagulant activities of Coumarin.
Prednylidene Prednylidene may increase the anticoagulant activities of Coumarin.
Fluocortin Fluocortin may increase the anticoagulant activities of Coumarin.
Fluperolone Fluperolone may increase the anticoagulant activities of Coumarin.
Cloprednol Cloprednol may increase the anticoagulant activities of Coumarin.
Fluclorolone Fluclorolone may increase the anticoagulant activities of Coumarin.
Fluticasone Fluticasone may increase the anticoagulant activities of Coumarin.
Mometasone furoate Mometasone furoate may increase the anticoagulant activities of Coumarin.
Hydrocortisone acetate Hydrocortisone acetate may increase the anticoagulant activities of Coumarin.
Hydrocortisone cypionate Hydrocortisone cypionate may increase the anticoagulant activities of Coumarin.
Hydrocortisone succinate Hydrocortisone succinate may increase the anticoagulant activities of Coumarin.
Prednisolone phosphate Prednisolone phosphate may increase the anticoagulant activities of Coumarin.
Prednisolone hemisuccinate Prednisolone hemisuccinate may increase the anticoagulant activities of Coumarin.
Methylprednisolone hemisuccinate Methylprednisolone hemisuccinate may increase the anticoagulant activities of Coumarin.
Prednisone acetate Prednisone acetate may increase the anticoagulant activities of Coumarin.
Clocortolone acetate Clocortolone acetate may increase the anticoagulant activities of Coumarin.
Melengestrol acetate Melengestrol acetate may increase the anticoagulant activities of Coumarin.
Betamethasone phosphate Betamethasone phosphate may increase the anticoagulant activities of Coumarin.
Cortisone Cortisone may increase the anticoagulant activities of Coumarin.
Clobetasol propionate Clobetasol propionate may increase the anticoagulant activities of Coumarin.
Fluocinonide Fluocinonide may increase the anticoagulant activities of Coumarin.
Hydrocortisone butyrate Hydrocortisone butyrate may increase the anticoagulant activities of Coumarin.
Desoximetasone Desoximetasone may increase the anticoagulant activities of Coumarin.
Mometasone Mometasone may increase the anticoagulant activities of Coumarin.
Fluocortolone Fluocortolone may increase the anticoagulant activities of Coumarin.
Prednisolone acetate Prednisolone acetate may increase the anticoagulant activities of Coumarin.
Fluorometholone Fluorometholone may increase the anticoagulant activities of Coumarin.
Difluocortolone Difluocortolone may increase the anticoagulant activities of Coumarin.
Flumethasone Flumethasone may increase the anticoagulant activities of Coumarin.
Methylprednisolone aceponate Methylprednisolone aceponate may increase the anticoagulant activities of Coumarin.
Erlotinib The serum concentration of Coumarin can be increased when it is combined with Erlotinib.
Acetaminophen Acetaminophen may increase the anticoagulant activities of Coumarin.
Allopurinol The risk or severity of bleeding can be increased when Allopurinol is combined with Coumarin.
Azathioprine The therapeutic efficacy of Coumarin can be decreased when used in combination with Azathioprine.
Chloral hydrate The protein binding of Coumarin can be decreased when combined with Chloral hydrate.
Methylphenidate The metabolism of Coumarin can be decreased when combined with Methylphenidate.
Dexmethylphenidate The metabolism of Coumarin can be decreased when combined with Dexmethylphenidate.
Disulfiram Disulfiram may increase the anticoagulant activities of Coumarin.
Etacrynic acid The protein binding of Coumarin can be decreased when combined with Etacrynic acid.
Ethotoin The therapeutic efficacy of Coumarin can be increased when used in combination with Ethotoin.
Etoposide The therapeutic efficacy of Coumarin can be increased when used in combination with Etoposide.
Exenatide Exenatide can cause an increase in the absorption of Coumarin resulting in an increased serum concentration and potentially a worsening of adverse effects.
Gefitinib Gefitinib may increase the anticoagulant activities of Coumarin.
Ginkgo biloba Ginkgo biloba may increase the anticoagulant activities of Coumarin.
Glutethimide The therapeutic efficacy of Coumarin can be decreased when used in combination with Glutethimide.
Ifosfamide The risk or severity of bleeding can be increased when Ifosfamide is combined with Coumarin.

Target Protein

Carbonic anhydrase 4 CA4
Carbonic anhydrase 1 CA1
Carbonic anhydrase 6 CA6
Carbonic anhydrase 9 CA9
Carbonic anhydrase 14 CA14
Carbonic anhydrase 2 CA2
Carbonic anhydrase 12 CA12
Cytochrome P450 2A6 CYP2A6

Referensi & Sumber

Synthesis reference: Ernst-Christian Witte, Peter Neubert, Androniki Roesch, "2H-1-benzopyran-2-one derivatives, processes for the preparation thereof and pharmaceutical compositions containing them." U.S. Patent US4670439, issued May, 1974.

Contoh Produk & Brand

Produk: 0 • International brands: 0
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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