Aldosterone

DB04630

small molecule experimental investigational

Deskripsi

A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.

Struktur Molekul 2D

Berat 360.444
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1040 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Aldosterone.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Aldosterone.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Aldosterone.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Aldosterone.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Aldosterone.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Aldosterone.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Aldosterone.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Aldosterone.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Aldosterone.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Aldosterone.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Aldosterone.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Aldosterone.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Aldosterone.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Aldosterone.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Aldosterone.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Aldosterone.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Aldosterone.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Aldosterone.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Aldosterone.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Aldosterone.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Aldosterone.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Aldosterone.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Aldosterone.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Aldosterone.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Aldosterone.
Cladribine Aldosterone may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Aldosterone.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Aldosterone.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Aldosterone.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Aldosterone.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Aldosterone.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Aldosterone.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Aldosterone.
Vindesine The risk or severity of adverse effects can be increased when Vindesine is combined with Aldosterone.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Aldosterone.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Aldosterone.
Vinorelbine The risk or severity of adverse effects can be increased when Vinorelbine is combined with Aldosterone.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Aldosterone.
Sorafenib The risk or severity of adverse effects can be increased when Sorafenib is combined with Aldosterone.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Aldosterone.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Aldosterone.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Aldosterone.
Teniposide The risk or severity of adverse effects can be increased when Teniposide is combined with Aldosterone.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Aldosterone.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Aldosterone.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Aldosterone.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Aldosterone.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Aldosterone.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Aldosterone.
Cyclophosphamide The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Aldosterone.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Aldosterone.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Aldosterone.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Aldosterone.
Methotrexate The risk or severity of adverse effects can be increased when Methotrexate is combined with Aldosterone.
Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Aldosterone.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Aldosterone.
Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Aldosterone.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Aldosterone.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Aldosterone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Aldosterone.
Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Aldosterone.
Irinotecan The risk or severity of adverse effects can be increased when Irinotecan is combined with Aldosterone.
Etoposide The risk or severity of adverse effects can be increased when Etoposide is combined with Aldosterone.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Aldosterone.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Aldosterone.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Aldosterone.
Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Aldosterone.
Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Aldosterone.
Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Aldosterone.
Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Aldosterone.
Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Aldosterone.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Aldosterone.
Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Aldosterone.
Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Aldosterone.
Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Aldosterone.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Aldosterone.
Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Aldosterone.
Fludarabine The risk or severity of adverse effects can be increased when Fludarabine is combined with Aldosterone.
Flucytosine The risk or severity of adverse effects can be increased when Flucytosine is combined with Aldosterone.
Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Aldosterone.
Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Aldosterone.
Arsenic trioxide The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Aldosterone.
Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Aldosterone.
Ifosfamide The risk or severity of adverse effects can be increased when Ifosfamide is combined with Aldosterone.
Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Aldosterone.
Mitoxantrone The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Aldosterone.
Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Aldosterone.
Docetaxel The risk or severity of adverse effects can be increased when Docetaxel is combined with Aldosterone.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Aldosterone.
Decitabine The risk or severity of adverse effects can be increased when Decitabine is combined with Aldosterone.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Aldosterone.
Stepronin The risk or severity of adverse effects can be increased when Stepronin is combined with Aldosterone.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Aldosterone.
Castanospermine The risk or severity of adverse effects can be increased when Castanospermine is combined with Aldosterone.
Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Aldosterone.
2-Methoxyethanol The risk or severity of adverse effects can be increased when 2-Methoxyethanol is combined with Aldosterone.
Brequinar The risk or severity of adverse effects can be increased when Brequinar is combined with Aldosterone.
Pirfenidone The risk or severity of adverse effects can be increased when Aldosterone is combined with Pirfenidone.
Belinostat The risk or severity of adverse effects can be increased when Aldosterone is combined with Belinostat.
Trabectedin The risk or severity of adverse effects can be increased when Aldosterone is combined with Trabectedin.

Target Protein

Solute carrier family 12 member 1 SLC12A1
Mineralocorticoid receptor NR3C2
Glucocorticoid receptor NR3C1

Referensi & Sumber

Synthesis reference: Jack Fishman, Elliot Hahn, Gregory A. Smith, "Aldosterone biosynthesis inhibitor." U.S. Patent US5120724, issued December, 1969.
Artikel (PubMed)
  • PMID: 12788829
    Williams JS, Williams GH: 50th anniversary of aldosterone. J Clin Endocrinol Metab. 2003 Jun;88(6):2364-72.

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