1-benzylimidazole

DB04581

small molecule experimental

Deskripsi

1-benzylimidazole, an N-imidazole derivative, has been shown to have strong cardiotonic activity.

Struktur Molekul 2D

Berat 158.1998
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

545 Data
Valsartan 1-benzylimidazole may decrease the antihypertensive activities of Valsartan.
Ramipril 1-benzylimidazole may decrease the antihypertensive activities of Ramipril.
Esmolol 1-benzylimidazole may decrease the antihypertensive activities of Esmolol.
Betaxolol 1-benzylimidazole may decrease the antihypertensive activities of Betaxolol.
Reserpine 1-benzylimidazole may decrease the antihypertensive activities of Reserpine.
Remikiren 1-benzylimidazole may decrease the antihypertensive activities of Remikiren.
Torasemide 1-benzylimidazole may decrease the antihypertensive activities of Torasemide.
Guanadrel 1-benzylimidazole may decrease the antihypertensive activities of Guanadrel.
Metoprolol 1-benzylimidazole may decrease the antihypertensive activities of Metoprolol.
Isradipine 1-benzylimidazole may decrease the antihypertensive activities of Isradipine.
Olmesartan 1-benzylimidazole may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone 1-benzylimidazole may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside 1-benzylimidazole may decrease the antihypertensive activities of Nitroprusside.
Atenolol 1-benzylimidazole may decrease the antihypertensive activities of Atenolol.
Diltiazem 1-benzylimidazole may decrease the antihypertensive activities of Diltiazem.
Minoxidil 1-benzylimidazole may decrease the antihypertensive activities of Minoxidil.
Timolol 1-benzylimidazole may decrease the antihypertensive activities of Timolol.
Treprostinil 1-benzylimidazole may decrease the antihypertensive activities of Treprostinil.
Amlodipine 1-benzylimidazole may decrease the antihypertensive activities of Amlodipine.
Nimodipine 1-benzylimidazole may decrease the antihypertensive activities of Nimodipine.
Nisoldipine 1-benzylimidazole may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide 1-benzylimidazole may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin 1-benzylimidazole may decrease the antihypertensive activities of Prazosin.
Fosinopril 1-benzylimidazole may decrease the antihypertensive activities of Fosinopril.
Trandolapril 1-benzylimidazole may decrease the antihypertensive activities of Trandolapril.
Metolazone 1-benzylimidazole may decrease the antihypertensive activities of Metolazone.
Lercanidipine 1-benzylimidazole may decrease the antihypertensive activities of Lercanidipine.
Benazepril 1-benzylimidazole may decrease the antihypertensive activities of Benazepril.
Bosentan 1-benzylimidazole may decrease the antihypertensive activities of Bosentan.
Propranolol 1-benzylimidazole may decrease the antihypertensive activities of Propranolol.
Enalapril 1-benzylimidazole may decrease the antihypertensive activities of Enalapril.
Doxazosin 1-benzylimidazole may decrease the antihypertensive activities of Doxazosin.
Labetalol 1-benzylimidazole may decrease the antihypertensive activities of Labetalol.
Cyclothiazide 1-benzylimidazole may decrease the antihypertensive activities of Cyclothiazide.
Bisoprolol 1-benzylimidazole may decrease the antihypertensive activities of Bisoprolol.
Candoxatril 1-benzylimidazole may decrease the antihypertensive activities of Candoxatril.
Nicardipine 1-benzylimidazole may decrease the antihypertensive activities of Nicardipine.
Mecamylamine 1-benzylimidazole may decrease the antihypertensive activities of Mecamylamine.
Losartan 1-benzylimidazole may decrease the antihypertensive activities of Losartan.
Moexipril 1-benzylimidazole may decrease the antihypertensive activities of Moexipril.
Eplerenone 1-benzylimidazole may decrease the antihypertensive activities of Eplerenone.
Lisinopril 1-benzylimidazole may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin 1-benzylimidazole may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine 1-benzylimidazole may decrease the antihypertensive activities of Metyrosine.
Hydroflumethiazide 1-benzylimidazole may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine 1-benzylimidazole may decrease the antihypertensive activities of Cryptenamine.
Perindopril 1-benzylimidazole may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil 1-benzylimidazole may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam 1-benzylimidazole may decrease the antihypertensive activities of Fenoldopam.
Indapamide 1-benzylimidazole may decrease the antihypertensive activities of Indapamide.
Tadalafil 1-benzylimidazole may decrease the antihypertensive activities of Tadalafil.
Alprenolol 1-benzylimidazole may decrease the antihypertensive activities of Alprenolol.
Eprosartan 1-benzylimidazole may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide 1-benzylimidazole may decrease the antihypertensive activities of Chlorothiazide.
Quinapril 1-benzylimidazole may decrease the antihypertensive activities of Quinapril.
Pindolol 1-benzylimidazole may decrease the antihypertensive activities of Pindolol.
Telmisartan 1-benzylimidazole may decrease the antihypertensive activities of Telmisartan.
Methyldopa 1-benzylimidazole may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide 1-benzylimidazole may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide 1-benzylimidazole may decrease the antihypertensive activities of Trichlormethiazide.
Felodipine 1-benzylimidazole may decrease the antihypertensive activities of Felodipine.
Irbesartan 1-benzylimidazole may decrease the antihypertensive activities of Irbesartan.
Nitrendipine 1-benzylimidazole may decrease the antihypertensive activities of Nitrendipine.
Deserpidine 1-benzylimidazole may decrease the antihypertensive activities of Deserpidine.
Pentolinium 1-benzylimidazole may decrease the antihypertensive activities of Pentolinium.
Trimethaphan 1-benzylimidazole may decrease the antihypertensive activities of Trimethaphan.
Diazoxide 1-benzylimidazole may decrease the antihypertensive activities of Diazoxide.
Carvedilol 1-benzylimidazole may decrease the antihypertensive activities of Carvedilol.
Bretylium 1-benzylimidazole may decrease the antihypertensive activities of Bretylium.
Terazosin 1-benzylimidazole may decrease the antihypertensive activities of Terazosin.
Guanethidine 1-benzylimidazole may decrease the antihypertensive activities of Guanethidine.
Acebutolol 1-benzylimidazole may decrease the antihypertensive activities of Acebutolol.
Captopril 1-benzylimidazole may decrease the antihypertensive activities of Captopril.
Nadolol 1-benzylimidazole may decrease the antihypertensive activities of Nadolol.
Epoprostenol 1-benzylimidazole may decrease the antihypertensive activities of Epoprostenol.
Bepridil 1-benzylimidazole may decrease the antihypertensive activities of Bepridil.
Hydralazine 1-benzylimidazole may decrease the antihypertensive activities of Hydralazine.
Bevantolol 1-benzylimidazole may decrease the antihypertensive activities of Bevantolol.
Practolol 1-benzylimidazole may decrease the antihypertensive activities of Practolol.
Polythiazide 1-benzylimidazole may decrease the antihypertensive activities of Polythiazide.
Cilazapril 1-benzylimidazole may decrease the antihypertensive activities of Cilazapril.
Saprisartan 1-benzylimidazole may decrease the antihypertensive activities of Saprisartan.
Spirapril 1-benzylimidazole may decrease the antihypertensive activities of Spirapril.
Penbutolol 1-benzylimidazole may decrease the antihypertensive activities of Penbutolol.
Mibefradil 1-benzylimidazole may decrease the antihypertensive activities of Mibefradil.
Oxprenolol 1-benzylimidazole may decrease the antihypertensive activities of Oxprenolol.
Dexpropranolol 1-benzylimidazole may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid 1-benzylimidazole may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine 1-benzylimidazole may decrease the antihypertensive activities of Debrisoquine.
Celiprolol 1-benzylimidazole may decrease the antihypertensive activities of Celiprolol.
Nebivolol 1-benzylimidazole may decrease the antihypertensive activities of Nebivolol.
Sitaxentan 1-benzylimidazole may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan 1-benzylimidazole may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine 1-benzylimidazole may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine 1-benzylimidazole may decrease the antihypertensive activities of Nilvadipine.
Pinacidil 1-benzylimidazole may decrease the antihypertensive activities of Pinacidil.
Bupranolol 1-benzylimidazole may decrease the antihypertensive activities of Bupranolol.
Temocapril 1-benzylimidazole may decrease the antihypertensive activities of Temocapril.
Riociguat 1-benzylimidazole may decrease the antihypertensive activities of Riociguat.
Macitentan 1-benzylimidazole may decrease the antihypertensive activities of Macitentan.

Target Protein

Cytochrome P450 11B1, mitochondrial CYP11B1
Glutaminyl-peptide cyclotransferase QPCT

Referensi & Sumber

Synthesis reference: Natsuo Sawa, Takeshi Masuda, Shozo Miura, Naoki Kano, Kazuo Kamagata, Masayuki Ito, "Process for preparation of 1-benzylimidazole compound." U.S. Patent US5021584, issued June 04, 1991.
Artikel (PubMed)
  • PMID: 7684507
    Mori Y, Iimura K, Hirano K: N-benzylimidazole, a potent inducer of rat liver enzymes involved in mutagenic activation of various carcinogens. Mutat Res. 1993 Jun;302(2):129-33.
  • PMID: 6142461
    Lucas J, Chan PS, Mateja N, Cervoni P, Ronsberg MA, Lipchuck LM: 1-Benzylimidazole, a thromboxane synthetase inhibitor acutely lowers blood pressure mainly by alpha-adrenoceptor blockade in spontaneously hypertensive rats (SHR). Prostaglandins Leukot Med. 1983 Dec;12(4):409-21.
  • PMID: 1159635
    Tuttle RS, Garcia-Minor C, Simon M: Cardiovascular effects of 1-benzylimidazole. J Pharmacol Exp Ther. 1975 Sep;194(3):624-32.

Contoh Produk & Brand

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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