Fleroxacin

DB04576

small molecule experimental

Deskripsi

Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase. Fleroxacin is not an inhibitor of CYP1A2.A39048

Struktur Molekul 2D

Berat 369.344
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly and well absorbed from the gastrointestinal tract after oral administration.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

4 Data
  • 1. Avoid milk and dairy products.
  • 2. Limit caffeine intake.
  • 3. Take with a full glass of water.
  • 4. Take with or without food.

Interaksi Obat

847 Data
Didanosine Didanosine can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Probenecid Probenecid may decrease the excretion rate of Fleroxacin which could result in a higher serum level.
Quinapril Quinapril can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate Calcium acetate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Dextran Iron Dextran can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Calcium can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum carbonate Lanthanum carbonate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric carboxymaltose Ferric carboxymaltose can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose Iron sucrose can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric pyrophosphate Ferric pyrophosphate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium citrate Calcium citrate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium gluconate Calcium gluconate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric sulfate Ferric sulfate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric cation Ferric cation can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetraferric tricitrate decahydrate Tetraferric tricitrate decahydrate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum III cation Lanthanum III cation can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium polycarbophil Calcium polycarbophil can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric oxyhydroxide Ferric oxyhydroxide can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Sucralfate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nitrofurantoin The therapeutic efficacy of Fleroxacin can be decreased when used in combination with Nitrofurantoin.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Fleroxacin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Fleroxacin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fleroxacin.
Insulin human The therapeutic efficacy of Insulin human can be increased when used in combination with Fleroxacin.
Insulin lispro The therapeutic efficacy of Insulin lispro can be increased when used in combination with Fleroxacin.
Insulin pork The therapeutic efficacy of Insulin pork can be increased when used in combination with Fleroxacin.
Troglitazone The therapeutic efficacy of Troglitazone can be increased when used in combination with Fleroxacin.
Glimepiride The therapeutic efficacy of Glimepiride can be increased when used in combination with Fleroxacin.
Sulfisoxazole The therapeutic efficacy of Sulfisoxazole can be increased when used in combination with Fleroxacin.
Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Fleroxacin.
Metformin The therapeutic efficacy of Metformin can be increased when used in combination with Fleroxacin.
Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Fleroxacin.
Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Fleroxacin.
Acetohexamide The therapeutic efficacy of Acetohexamide can be increased when used in combination with Fleroxacin.
Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Fleroxacin.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Fleroxacin.
Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Fleroxacin.
Pentamidine The therapeutic efficacy of Pentamidine can be increased when used in combination with Fleroxacin.
Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Fleroxacin.
Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Fleroxacin.
Phenformin The therapeutic efficacy of Phenformin can be increased when used in combination with Fleroxacin.
Sulfamethoxazole The therapeutic efficacy of Sulfamethoxazole can be increased when used in combination with Fleroxacin.
Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Fleroxacin.
Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Fleroxacin.
Gliclazide The therapeutic efficacy of Gliclazide can be increased when used in combination with Fleroxacin.
Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Fleroxacin.
Pioglitazone The therapeutic efficacy of Pioglitazone can be increased when used in combination with Fleroxacin.
Bromocriptine The therapeutic efficacy of Bromocriptine can be increased when used in combination with Fleroxacin.
Gliquidone The therapeutic efficacy of Gliquidone can be increased when used in combination with Fleroxacin.
Mitiglinide The therapeutic efficacy of Mitiglinide can be increased when used in combination with Fleroxacin.
Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Fleroxacin.
Sunitinib The therapeutic efficacy of Sunitinib can be increased when used in combination with Fleroxacin.
Exenatide The therapeutic efficacy of Exenatide can be increased when used in combination with Fleroxacin.
Mecasermin The therapeutic efficacy of Mecasermin can be increased when used in combination with Fleroxacin.
Pramlintide The therapeutic efficacy of Pramlintide can be increased when used in combination with Fleroxacin.
Glisoxepide The therapeutic efficacy of Glisoxepide can be increased when used in combination with Fleroxacin.
Insulin aspart The therapeutic efficacy of Insulin aspart can be increased when used in combination with Fleroxacin.
Insulin glulisine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Fleroxacin.
Glymidine The therapeutic efficacy of Glymidine can be increased when used in combination with Fleroxacin.
AICA ribonucleotide The therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Fleroxacin.
Buformin The therapeutic efficacy of Buformin can be increased when used in combination with Fleroxacin.
Vildagliptin The therapeutic efficacy of Vildagliptin can be increased when used in combination with Fleroxacin.
Voglibose The therapeutic efficacy of Voglibose can be increased when used in combination with Fleroxacin.
NN344 The therapeutic efficacy of NN344 can be increased when used in combination with Fleroxacin.
AMG-222 The therapeutic efficacy of AMG-222 can be increased when used in combination with Fleroxacin.
Bisegliptin The therapeutic efficacy of Bisegliptin can be increased when used in combination with Fleroxacin.
Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Fleroxacin.
Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Fleroxacin.
Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Fleroxacin.
Liraglutide The therapeutic efficacy of Liraglutide can be increased when used in combination with Fleroxacin.
Gosogliptin The therapeutic efficacy of Gosogliptin can be increased when used in combination with Fleroxacin.
Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Fleroxacin.
Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Fleroxacin.
Glibornuride The therapeutic efficacy of Glibornuride can be increased when used in combination with Fleroxacin.
Benfluorex The therapeutic efficacy of Benfluorex can be increased when used in combination with Fleroxacin.
Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Fleroxacin.
Albiglutide The therapeutic efficacy of Albiglutide can be increased when used in combination with Fleroxacin.
Dulaglutide The therapeutic efficacy of Dulaglutide can be increased when used in combination with Fleroxacin.
Lobeglitazone The therapeutic efficacy of Lobeglitazone can be increased when used in combination with Fleroxacin.
Netoglitazone The therapeutic efficacy of Netoglitazone can be increased when used in combination with Fleroxacin.
Rivoglitazone The therapeutic efficacy of Rivoglitazone can be increased when used in combination with Fleroxacin.
Ciglitazone The therapeutic efficacy of Ciglitazone can be increased when used in combination with Fleroxacin.
Lixisenatide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Fleroxacin.
Insulin beef The therapeutic efficacy of Insulin beef can be increased when used in combination with Fleroxacin.
Insulin degludec The therapeutic efficacy of Insulin degludec can be increased when used in combination with Fleroxacin.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be increased when used in combination with Fleroxacin.
Insulin tregopil The therapeutic efficacy of Insulin tregopil can be increased when used in combination with Fleroxacin.
Ipragliflozin The therapeutic efficacy of Ipragliflozin can be increased when used in combination with Fleroxacin.
Dutogliptin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Fleroxacin.
Allicin The therapeutic efficacy of Allicin can be increased when used in combination with Fleroxacin.
Tofogliflozin The therapeutic efficacy of Tofogliflozin can be increased when used in combination with Fleroxacin.
Ertugliflozin The therapeutic efficacy of Ertugliflozin can be increased when used in combination with Fleroxacin.
2,4-thiazolidinedione The therapeutic efficacy of 2,4-thiazolidinedione can be increased when used in combination with Fleroxacin.
Teneligliptin The therapeutic efficacy of Teneligliptin can be increased when used in combination with Fleroxacin.
Omarigliptin The therapeutic efficacy of Omarigliptin can be increased when used in combination with Fleroxacin.
Carmegliptin The therapeutic efficacy of Carmegliptin can be increased when used in combination with Fleroxacin.
Gemigliptin The therapeutic efficacy of Gemigliptin can be increased when used in combination with Fleroxacin.
Anagliptin The therapeutic efficacy of Anagliptin can be increased when used in combination with Fleroxacin.

Target Protein

DNA topoisomerase 2-beta TOP2B
DNA gyrase subunit A gyrA
DNA topoisomerase 4 subunit A parC
DNA topoisomerase 2-alpha TOP2A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 1510417
    Fuhr U, Anders EM, Mahr G, Sorgel F, Staib AH: Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro. Antimicrob Agents Chemother. 1992 May;36(5):942-8.

Contoh Produk & Brand

Produk: 0 • International brands: 4
International Brands
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  • Megalone
  • Megalosin
  • Quinodis

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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