Estrone sulfate

DB04574

small molecule approved

Deskripsi

Estrone sulfate (as estropipate) is a form of estrogen. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer (particularly in men and postmenopausal women), treatment of prostate cancer and prevention of osteoporosis.

Struktur Molekul 2D

Berat 350.429
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Estropipate is well absorbed through the skin and gastrointestinal tract. When applied for a local action, absorption is usually sufficient to cause systemic effects.

Metabolisme

Exogenous estrogens are metabolized in the same manner as endogenous estrogens. Circulating estrogens exist in a dynamic equilibrium of metabolic interconversions. These transformations take place mainly in the liver. Estradiol is converted reversibly to estrone, and both can be converted to estriol, which is the major urinary metabolite. Estrogens also undergo enterohepatic recirculation via sulfate and glucuronide conjugation in the liver, biliary secretion of conjugates into the intestine, and hydrolysis in the gut followed by reabsorption. In postmenopausal women, a significant proportion of the circulating estrogens exist as sulfate conjugates, especially estrone sulfate, which serves as a circulating reservoir for the formation of more active estrogens.

Rute Eliminasi

Estradiol, estrone and estriol are excreted in the urine along with glucuronide and sulfate conjugates

Interaksi Makanan

1 Data
  • 1. Take with food. Food decreases nausea.

Interaksi Obat

1850 Data
Deferasirox The serum concentration of Estrone sulfate can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Estrone sulfate can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Estrone sulfate can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Estrone sulfate can be decreased when it is combined with Teriflunomide.
Aprepitant The serum concentration of Estrone sulfate can be decreased when it is combined with Aprepitant.
Exenatide Exenatide can cause a decrease in the absorption of Estrone sulfate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Thalidomide Estrone sulfate may increase the thrombogenic activities of Thalidomide.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Estrone sulfate.
Prasterone The risk or severity of adverse effects can be increased when Prasterone is combined with Estrone sulfate.
Exemestane The therapeutic efficacy of Exemestane can be decreased when used in combination with Estrone sulfate.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Estrone sulfate.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Estrone sulfate.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Estrone sulfate.
Lenalidomide Estrone sulfate may increase the thrombogenic activities of Lenalidomide.
Ospemifene The risk or severity of adverse effects can be increased when Estrone sulfate is combined with Ospemifene.
Abiraterone The serum concentration of Estrone sulfate can be increased when it is combined with Abiraterone.
Cetuximab Estrone sulfate may increase the thrombogenic activities of Cetuximab.
Human immunoglobulin G Estrone sulfate may increase the thrombogenic activities of Human immunoglobulin G.
Omalizumab Estrone sulfate may increase the thrombogenic activities of Omalizumab.
Gemtuzumab ozogamicin Estrone sulfate may increase the thrombogenic activities of Gemtuzumab ozogamicin.
Indium In-111 satumomab pendetide Estrone sulfate may increase the thrombogenic activities of Indium In-111 satumomab pendetide.
Trastuzumab Estrone sulfate may increase the thrombogenic activities of Trastuzumab.
Rituximab Estrone sulfate may increase the thrombogenic activities of Rituximab.
Basiliximab Estrone sulfate may increase the thrombogenic activities of Basiliximab.
Muromonab Estrone sulfate may increase the thrombogenic activities of Muromonab.
Digoxin Immune Fab (Ovine) Estrone sulfate may increase the thrombogenic activities of Digoxin Immune Fab (Ovine).
Ibritumomab tiuxetan Estrone sulfate may increase the thrombogenic activities of Ibritumomab tiuxetan.
Alemtuzumab Estrone sulfate may increase the thrombogenic activities of Alemtuzumab.
Efalizumab Estrone sulfate may increase the thrombogenic activities of Efalizumab.
Antithymocyte immunoglobulin (rabbit) Estrone sulfate may increase the thrombogenic activities of Antithymocyte immunoglobulin (rabbit).
Natalizumab Estrone sulfate may increase the thrombogenic activities of Natalizumab.
Palivizumab Estrone sulfate may increase the thrombogenic activities of Palivizumab.
Daclizumab Estrone sulfate may increase the thrombogenic activities of Daclizumab.
Bevacizumab Estrone sulfate may increase the thrombogenic activities of Bevacizumab.
Technetium Tc-99m arcitumomab Estrone sulfate may increase the thrombogenic activities of Technetium Tc-99m arcitumomab.
Eculizumab Estrone sulfate may increase the thrombogenic activities of Eculizumab.
Panitumumab Estrone sulfate may increase the thrombogenic activities of Panitumumab.
Ranibizumab Estrone sulfate may increase the thrombogenic activities of Ranibizumab.
Galiximab Estrone sulfate may increase the thrombogenic activities of Galiximab.
Pexelizumab Estrone sulfate may increase the thrombogenic activities of Pexelizumab.
Epratuzumab Estrone sulfate may increase the thrombogenic activities of Epratuzumab.
Bectumomab Estrone sulfate may increase the thrombogenic activities of Bectumomab.
Oregovomab Estrone sulfate may increase the thrombogenic activities of Oregovomab.
IGN311 Estrone sulfate may increase the thrombogenic activities of IGN311.
Adecatumumab Estrone sulfate may increase the thrombogenic activities of Adecatumumab.
Labetuzumab Estrone sulfate may increase the thrombogenic activities of Labetuzumab.
Matuzumab Estrone sulfate may increase the thrombogenic activities of Matuzumab.
Fontolizumab Estrone sulfate may increase the thrombogenic activities of Fontolizumab.
Bavituximab Estrone sulfate may increase the thrombogenic activities of Bavituximab.
CR002 Estrone sulfate may increase the thrombogenic activities of CR002.
Rozrolimupab Estrone sulfate may increase the thrombogenic activities of Rozrolimupab.
Girentuximab Estrone sulfate may increase the thrombogenic activities of Girentuximab.
Obiltoxaximab Estrone sulfate may increase the thrombogenic activities of Obiltoxaximab.
XTL-001 Estrone sulfate may increase the thrombogenic activities of XTL-001.
NAV 1800 Estrone sulfate may increase the thrombogenic activities of NAV 1800.
Briakinumab Estrone sulfate may increase the thrombogenic activities of Briakinumab.
Otelixizumab Estrone sulfate may increase the thrombogenic activities of Otelixizumab.
AMG 108 Estrone sulfate may increase the thrombogenic activities of AMG 108.
Iratumumab Estrone sulfate may increase the thrombogenic activities of Iratumumab.
Enokizumab Estrone sulfate may increase the thrombogenic activities of Enokizumab.
Ramucirumab Estrone sulfate may increase the thrombogenic activities of Ramucirumab.
Farletuzumab Estrone sulfate may increase the thrombogenic activities of Farletuzumab.
Veltuzumab Estrone sulfate may increase the thrombogenic activities of Veltuzumab.
Ustekinumab Estrone sulfate may increase the thrombogenic activities of Ustekinumab.
PRO-542 Estrone sulfate may increase the thrombogenic activities of PRO-542.
TNX-901 Estrone sulfate may increase the thrombogenic activities of TNX-901.
Inotuzumab ozogamicin Estrone sulfate may increase the thrombogenic activities of Inotuzumab ozogamicin.
RI 624 Estrone sulfate may increase the thrombogenic activities of RI 624.
Stamulumab Estrone sulfate may increase the thrombogenic activities of MYO-029.
CT-011 Estrone sulfate may increase the thrombogenic activities of CT-011.
Leronlimab Estrone sulfate may increase the thrombogenic activities of Leronlimab.
Glembatumumab vedotin Estrone sulfate may increase the thrombogenic activities of Glembatumumab vedotin.
Olaratumab Estrone sulfate may increase the thrombogenic activities of Olaratumab.
IPH 2101 Estrone sulfate may increase the thrombogenic activities of IPH 2101.
TB-402 Estrone sulfate may increase the thrombogenic activities of TB-402.
Caplacizumab Estrone sulfate may increase the thrombogenic activities of Caplacizumab.
IMC-1C11 Estrone sulfate may increase the thrombogenic activities of IMC-1C11.
Eldelumab Estrone sulfate may increase the thrombogenic activities of Eldelumab.
Lumiliximab Estrone sulfate may increase the thrombogenic activities of Lumiliximab.
Nimotuzumab Estrone sulfate may increase the thrombogenic activities of Nimotuzumab.
Clenoliximab Estrone sulfate may increase the thrombogenic activities of Clenoliximab.
BIIB015 Estrone sulfate may increase the thrombogenic activities of BIIB015.
Sonepcizumab Estrone sulfate may increase the thrombogenic activities of Sonepcizumab.
Motavizumab Estrone sulfate may increase the thrombogenic activities of Motavizumab.
Elotuzumab Estrone sulfate may increase the thrombogenic activities of Elotuzumab.
Carotuximab Estrone sulfate may increase the thrombogenic activities of Carotuximab.
XmAb 2513 Estrone sulfate may increase the thrombogenic activities of XmAb 2513.
Lucatumumab Estrone sulfate may increase the thrombogenic activities of Lucatumumab.
Pertuzumab Estrone sulfate may increase the thrombogenic activities of Pertuzumab.
Siplizumab Estrone sulfate may increase the thrombogenic activities of Siplizumab.
Apolizumab Estrone sulfate may increase the thrombogenic activities of Apolizumab.
Sibrotuzumab Estrone sulfate may increase the thrombogenic activities of Sibrotuzumab.
Bivatuzumab Estrone sulfate may increase the thrombogenic activities of Bivatuzumab.
Lerdelimumab Estrone sulfate may increase the thrombogenic activities of Lerdelimumab.
Lexatumumab Estrone sulfate may increase the thrombogenic activities of Lexatumumab.
Reslizumab Estrone sulfate may increase the thrombogenic activities of Reslizumab.
Teplizumab Estrone sulfate may increase the thrombogenic activities of Teplizumab.
Catumaxomab Estrone sulfate may increase the thrombogenic activities of Catumaxomab.
Mepolizumab Estrone sulfate may increase the thrombogenic activities of Mepolizumab.
Denosumab Estrone sulfate may increase the thrombogenic activities of Denosumab.

Target Protein

Estrogen receptor ESR1
Estrogen receptor beta ESR2

Referensi & Sumber

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