Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. The photoactivated form produces interstrand linkages in DNA resulting in cell apoptosis. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.3 The compound is has been explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Porfimer sodium | Trioxsalen may increase the photosensitizing activities of Porfimer sodium. |
| Verteporfin | Trioxsalen may increase the photosensitizing activities of Verteporfin. |
| Dexmethylphenidate | The serum concentration of the active metabolites of Trioxsalen can be increased when Trioxsalen is used in combination with Dexmethylphenidate. |
| Glimepiride | The therapeutic efficacy of Glimepiride can be increased when used in combination with Trioxsalen. |
| Acetohexamide | The therapeutic efficacy of Acetohexamide can be increased when used in combination with Trioxsalen. |
| Chlorpropamide | The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Trioxsalen. |
| Tolazamide | The therapeutic efficacy of Tolazamide can be increased when used in combination with Trioxsalen. |
| Glyburide | The therapeutic efficacy of Glyburide can be increased when used in combination with Trioxsalen. |
| Glipizide | The therapeutic efficacy of Glipizide can be increased when used in combination with Trioxsalen. |
| Gliclazide | The therapeutic efficacy of Gliclazide can be increased when used in combination with Trioxsalen. |
| Tolbutamide | The therapeutic efficacy of Tolbutamide can be increased when used in combination with Trioxsalen. |
| Gliquidone | The therapeutic efficacy of Gliquidone can be increased when used in combination with Trioxsalen. |
| Glisoxepide | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Trioxsalen. |
| Glibornuride | The therapeutic efficacy of Glibornuride can be increased when used in combination with Trioxsalen. |
| Carbutamide | The therapeutic efficacy of Carbutamide can be increased when used in combination with Trioxsalen. |
| Metahexamide | The therapeutic efficacy of Metahexamide can be increased when used in combination with Trioxsalen. |
| Tretinoin | The risk or severity of adverse effects can be increased when Tretinoin is combined with Trioxsalen. |
| Padeliporfin | Trioxsalen may increase the photosensitizing activities of Padeliporfin. |
| Lepirudin | The risk or severity of bleeding can be increased when Trioxsalen is combined with Lepirudin. |
| Doxycycline | The therapeutic efficacy of Trioxsalen can be increased when used in combination with Doxycycline. |
| Diazoxide | The serum concentration of Trioxsalen can be increased when it is combined with Diazoxide. |