Peringatan Keamanan

Latamoxef produces potentially life-threatening effects which include Bleeding, Hypothrombinemia, Platelet dysfunctioning. which are responsible for the discontinuation of Latamoxef therapy.
The symptomatic adverse reactions produced by Latamoxef are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Skin rashes, Hematuria, Hyperuricemia, Pyuria, Raised serum creatinine.

Latamoxef

DB04570

small molecule approved investigational

Deskripsi

Latamoxef is a broad- spectrum beta-lactam antibiotic similar in structure to the cephalosporins except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain cephalosporins. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.

Struktur Molekul 2D

Berat 520.473
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.6 hours
Volume Distribusi 8.51 L
Klirens (Clearance) -

Absorpsi

Rapidly absorbed after oral administration.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Renal Excretion accounts for 75 %

Interaksi Obat

796 Data
Probenecid The serum concentration of Latamoxef can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Latamoxef.
Tenofovir disoproxil Latamoxef may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Latamoxef may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Latamoxef may increase the nephrotoxic activities of Tenofovir.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Latamoxef.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Latamoxef.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Latamoxef.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Latamoxef.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Latamoxef.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Latamoxef.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Latamoxef.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Latamoxef.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Latamoxef.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Latamoxef.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Latamoxef.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Latamoxef.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Latamoxef.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Latamoxef.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Latamoxef.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Latamoxef.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Latamoxef.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Latamoxef.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Latamoxef.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Latamoxef.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Latamoxef.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Latamoxef.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Latamoxef.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Latamoxef.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Latamoxef.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Latamoxef.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Latamoxef.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Latamoxef.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Latamoxef.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Latamoxef.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Latamoxef.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Latamoxef.
Meloxicam The risk or severity of methemoglobinemia can be increased when Latamoxef is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Latamoxef.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Latamoxef.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Latamoxef.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Latamoxef.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Latamoxef.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Latamoxef.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Latamoxef.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Latamoxef.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Latamoxef.
Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Latamoxef.
Colistimethate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Latamoxef.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Latamoxef.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Latamoxef.
Cefprozil The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Latamoxef.
Olsalazine The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Lumiracoxib is combined with Latamoxef.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefamandole is combined with Latamoxef.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Latamoxef.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefonicid is combined with Latamoxef.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Cefoperazone is combined with Latamoxef.
Cefoxitin The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Latamoxef.
Ceftizoxime The risk or severity of nephrotoxicity can be increased when Ceftizoxime is combined with Latamoxef.
Magnesium salicylate The risk or severity of nephrotoxicity can be increased when Magnesium salicylate is combined with Latamoxef.
Salsalate The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Latamoxef.
Choline magnesium trisalicylate The risk or severity of nephrotoxicity can be increased when Choline magnesium trisalicylate is combined with Latamoxef.
Cefepime The risk or severity of nephrotoxicity can be increased when Cefepime is combined with Latamoxef.
Cefacetrile The risk or severity of nephrotoxicity can be increased when Cefacetrile is combined with Latamoxef.
Cefpodoxime The risk or severity of nephrotoxicity can be increased when Cefpodoxime is combined with Latamoxef.
Antrafenine The risk or severity of nephrotoxicity can be increased when Antrafenine is combined with Latamoxef.
Aminophenazone The risk or severity of nephrotoxicity can be increased when Aminophenazone is combined with Latamoxef.
Antipyrine The risk or severity of nephrotoxicity can be increased when Antipyrine is combined with Latamoxef.
Tiaprofenic acid The risk or severity of nephrotoxicity can be increased when Tiaprofenic acid is combined with Latamoxef.
Lopinavir The risk or severity of nephrotoxicity can be increased when Lopinavir is combined with Latamoxef.
Etoricoxib The risk or severity of nephrotoxicity can be increased when Etoricoxib is combined with Latamoxef.
Hydrolyzed Cephalothin The risk or severity of nephrotoxicity can be increased when Hydrolyzed Cephalothin is combined with Latamoxef.
Cephalothin Group The risk or severity of nephrotoxicity can be increased when Cephalothin Group is combined with Latamoxef.
Oxyphenbutazone The risk or severity of nephrotoxicity can be increased when Oxyphenbutazone is combined with Latamoxef.
Nimesulide The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Nimesulide.
Benoxaprofen The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Benoxaprofen.
Metamizole The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Metamizole.
Zomepirac The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Zomepirac.
Ceftobiprole The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Ceftobiprole.
Cimicoxib The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Cimicoxib.
Ceftaroline fosamil The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Ceftaroline fosamil.
Lornoxicam The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Lornoxicam.
Zaltoprofen The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Zaltoprofen.
Azapropazone The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Azapropazone.
Parecoxib The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Parecoxib.
Salicylamide The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Salicylamide.
Kebuzone The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Kebuzone.
Isoxicam The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Isoxicam.
Indoprofen The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Indoprofen.
Ibuproxam The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Ibuproxam.
Floctafenine The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Floctafenine.
Fenbufen The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Fenbufen.
Etofenamate The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Etofenamate.
Epirizole The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Epirizole.
Cefaloridine The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Cefaloridine.
Cefminox The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Cefminox.
Dexibuprofen The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Dexibuprofen.
Droxicam The risk or severity of nephrotoxicity can be increased when Latamoxef is combined with Droxicam.

Target Protein

Peptidoglycan synthase FtsI ftsI
Penicillin-binding protein 3 pbpC
Penicillin-binding protein 1A mrcA
Penicillin-binding protein 1B mrcB
D-alanyl-D-alanine carboxypeptidase DacB dacB

Referensi & Sumber

Artikel (PubMed)
  • PMID: 6217353
    Weitekamp MR, Aber RC: Prolonged bleeding times and bleeding diathesis associated with moxalactam administration. JAMA. 1983 Jan 7;249(1):69-71.
  • PMID: 3778044
    Brown RB, Klar J, Lemeshow S, Teres D, Pastides H, Sands M: Enhanced bleeding with cefoxitin or moxalactam. Statistical analysis within a defined population of 1493 patients. Arch Intern Med. 1986 Nov;146(11):2159-64.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul