Peringatan Keamanan

Oral, mouse: LD50 = 350 mg/kg; Oral, rat: LD50 = 250 mg/kg

Niflumic acid

DB04552

small molecule experimental

Deskripsi

Niflumic acid is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

Struktur Molekul 2D

Berat 282.218
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.5 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed following oral administration.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1430 Data
Amlodipine Niflumic acid may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Niflumic acid.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Niflumic acid.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Niflumic acid.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Niflumic acid.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Niflumic acid.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Niflumic acid.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Niflumic acid.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Niflumic acid.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Niflumic acid.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Niflumic acid.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Niflumic acid.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Niflumic acid.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Niflumic acid.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Niflumic acid.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Niflumic acid.
Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Niflumic acid.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Niflumic acid.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Niflumic acid.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Niflumic acid.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Niflumic acid.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Niflumic acid.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Niflumic acid.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Niflumic acid.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Niflumic acid.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Niflumic acid.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Niflumic acid.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Niflumic acid.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Niflumic acid.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Niflumic acid.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Niflumic acid.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Niflumic acid.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Niflumic acid.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Niflumic acid.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Niflumic acid.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Niflumic acid.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Niflumic acid.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Niflumic acid.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Niflumic acid.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Niflumic acid.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Niflumic acid.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Niflumic acid.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Niflumic acid.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Niflumic acid.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Niflumic acid.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Niflumic acid.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Niflumic acid.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Niflumic acid.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Niflumic acid.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Niflumic acid.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Niflumic acid.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Niflumic acid.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Niflumic acid.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Niflumic acid.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Niflumic acid.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Niflumic acid.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Niflumic acid.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Niflumic acid.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Niflumic acid.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Niflumic acid.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Niflumic acid.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Niflumic acid.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Niflumic acid.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Niflumic acid.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Niflumic acid.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Niflumic acid.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Niflumic acid.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Niflumic acid.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Niflumic acid.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Niflumic acid.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Niflumic acid.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Niflumic acid.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Niflumic acid.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Niflumic acid.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Niflumic acid.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Niflumic acid.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Niflumic acid.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Niflumic acid.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Niflumic acid.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Niflumic acid.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Niflumic acid.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Niflumic acid.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Niflumic acid.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Niflumic acid.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Niflumic acid.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Niflumic acid.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Niflumic acid.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Niflumic acid.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Niflumic acid.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Niflumic acid.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Niflumic acid.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Niflumic acid.
1-benzylimidazole The risk or severity of hypertension can be increased when Niflumic acid is combined with 1-benzylimidazole.
Iproniazid The risk or severity of hypertension can be increased when Niflumic acid is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Niflumic acid is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Niflumic acid is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Niflumic acid is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Niflumic acid is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Niflumic acid is combined with Iloperidone.
Indacaterol The risk or severity of hypertension can be increased when Niflumic acid is combined with Indacaterol.

Target Protein

Phospholipase A2 PLA2G1B
Prostaglandin G/H synthase 2 PTGS2
Chloride channel protein ClC-Ka CLCNKA
Prostaglandin G/H synthase 1 PTGS1
Cytosolic phospholipase A2 PLA2G4A
UDP-glucuronosyltransferase 1A9 UGT1A9

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9138686
    Criddle DN, de Moura RS, Greenwood IA, Large WA: Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol. 1997 Mar;120(5):813-8.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Niflam
  • Niflugel
  • Nifluril

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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