Cholesterol

DB04540

small molecule approved investigational

Deskripsi

The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.

Struktur Molekul 2D

Berat 386.6535
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

98 Data
Folic acid Cholesterol may increase the excretion rate of Folic acid which could result in a lower serum level and potentially a reduction in efficacy.
Allopurinol Cholesterol may increase the excretion rate of Allopurinol which could result in a lower serum level and potentially a reduction in efficacy.
Oxaliplatin Cholesterol may increase the excretion rate of Oxaliplatin which could result in a lower serum level and potentially a reduction in efficacy.
Fluorouracil Cholesterol may increase the excretion rate of Fluorouracil which could result in a lower serum level and potentially a reduction in efficacy.
Testosterone Cholesterol may increase the excretion rate of Testosterone which could result in a lower serum level and potentially a reduction in efficacy.
Clofarabine Cholesterol may increase the excretion rate of Clofarabine which could result in a lower serum level and potentially a reduction in efficacy.
Riluzole Cholesterol may increase the excretion rate of Riluzole which could result in a lower serum level and potentially a reduction in efficacy.
Sulfasalazine Cholesterol may increase the excretion rate of Sulfasalazine which could result in a lower serum level and potentially a reduction in efficacy.
Glyburide Cholesterol may increase the excretion rate of Glyburide which could result in a lower serum level and potentially a reduction in efficacy.
Leflunomide Cholesterol may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Rosuvastatin Cholesterol may increase the excretion rate of Rosuvastatin which could result in a lower serum level and potentially a reduction in efficacy.
Alvocidib Cholesterol may increase the excretion rate of Alvocidib which could result in a lower serum level and potentially a reduction in efficacy.
Teriflunomide Cholesterol may increase the excretion rate of Teriflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Riociguat Cholesterol may increase the excretion rate of Riociguat which could result in a lower serum level and potentially a reduction in efficacy.
Fimasartan Cholesterol may increase the excretion rate of Fimasartan which could result in a lower serum level and potentially a reduction in efficacy.
Delafloxacin Cholesterol may increase the excretion rate of Delafloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Brigatinib Cholesterol may increase the excretion rate of Brigatinib which could result in a lower serum level and potentially a reduction in efficacy.
Enasidenib Cholesterol may increase the excretion rate of Enasidenib which could result in a lower serum level and potentially a reduction in efficacy.
Testosterone cypionate Cholesterol may increase the excretion rate of Testosterone cypionate which could result in a lower serum level and potentially a reduction in efficacy.
Testosterone enanthate Cholesterol may increase the excretion rate of Testosterone enanthate which could result in a lower serum level and potentially a reduction in efficacy.
Pravastatin Cholesterol may increase the excretion rate of Pravastatin which could result in a lower serum level and potentially a reduction in efficacy.
Conjugated estrogens Cholesterol may increase the excretion rate of Conjugated estrogens which could result in a lower serum level and potentially a reduction in efficacy.
Gefitinib Cholesterol may increase the excretion rate of Gefitinib which could result in a lower serum level and potentially a reduction in efficacy.
Cerivastatin Cholesterol may increase the excretion rate of Cerivastatin which could result in a lower serum level and potentially a reduction in efficacy.
Teniposide Cholesterol may increase the excretion rate of Teniposide which could result in a lower serum level and potentially a reduction in efficacy.
Prazosin Cholesterol may increase the excretion rate of Prazosin which could result in a lower serum level and potentially a reduction in efficacy.
Raloxifene Cholesterol may increase the excretion rate of Raloxifene which could result in a lower serum level and potentially a reduction in efficacy.
Celecoxib Cholesterol may increase the excretion rate of Celecoxib which could result in a lower serum level and potentially a reduction in efficacy.
Zidovudine Cholesterol may increase the excretion rate of Zidovudine which could result in a lower serum level and potentially a reduction in efficacy.
Ritonavir Cholesterol may increase the excretion rate of Ritonavir which could result in a lower serum level and potentially a reduction in efficacy.
Vincristine Cholesterol may increase the excretion rate of Vincristine which could result in a lower serum level and potentially a reduction in efficacy.
Methotrexate Cholesterol may increase the excretion rate of Methotrexate which could result in a lower serum level and potentially a reduction in efficacy.
Ivermectin Cholesterol may increase the excretion rate of Ivermectin which could result in a lower serum level and potentially a reduction in efficacy.
Imatinib Cholesterol may increase the excretion rate of Imatinib which could result in a lower serum level and potentially a reduction in efficacy.
Sumatriptan Cholesterol may increase the excretion rate of Sumatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Tamoxifen Cholesterol may increase the excretion rate of Tamoxifen which could result in a lower serum level and potentially a reduction in efficacy.
Mycophenolate mofetil Cholesterol may increase the excretion rate of Mycophenolate mofetil which could result in a lower serum level and potentially a reduction in efficacy.
Daunorubicin Cholesterol may increase the excretion rate of Daunorubicin which could result in a lower serum level and potentially a reduction in efficacy.
Nitrofurantoin Cholesterol may increase the excretion rate of Nitrofurantoin which could result in a lower serum level and potentially a reduction in efficacy.
Lamivudine Cholesterol may increase the excretion rate of Lamivudine which could result in a lower serum level and potentially a reduction in efficacy.
Irinotecan Cholesterol may increase the excretion rate of Irinotecan which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Cholesterol may increase the excretion rate of Etoposide which could result in a lower serum level and potentially a reduction in efficacy.
Donepezil Cholesterol may increase the excretion rate of Donepezil which could result in a lower serum level and potentially a reduction in efficacy.
Dactinomycin Cholesterol may increase the excretion rate of Dactinomycin which could result in a lower serum level and potentially a reduction in efficacy.
Ezetimibe Cholesterol may increase the excretion rate of Ezetimibe which could result in a lower serum level and potentially a reduction in efficacy.
Doxorubicin Cholesterol may increase the excretion rate of Doxorubicin which could result in a lower serum level and potentially a reduction in efficacy.
Topotecan Cholesterol may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Tegaserod Cholesterol may increase the excretion rate of Tegaserod which could result in a lower serum level and potentially a reduction in efficacy.
Mitoxantrone Cholesterol may increase the excretion rate of Mitoxantrone which could result in a lower serum level and potentially a reduction in efficacy.
Dasatinib Cholesterol may increase the excretion rate of Dasatinib which could result in a lower serum level and potentially a reduction in efficacy.
Camptothecin Cholesterol may increase the excretion rate of Camptothecin which could result in a lower serum level and potentially a reduction in efficacy.
Nilotinib Cholesterol may increase the excretion rate of Nilotinib which could result in a lower serum level and potentially a reduction in efficacy.
Rivaroxaban Cholesterol may increase the excretion rate of Rivaroxaban which could result in a lower serum level and potentially a reduction in efficacy.
Simeprevir Cholesterol may increase the excretion rate of Simeprevir which could result in a lower serum level and potentially a reduction in efficacy.
Pazopanib Cholesterol may increase the excretion rate of Pazopanib which could result in a lower serum level and potentially a reduction in efficacy.
Apixaban Cholesterol may increase the excretion rate of Apixaban which could result in a lower serum level and potentially a reduction in efficacy.
Vemurafenib Cholesterol may increase the excretion rate of Vemurafenib which could result in a lower serum level and potentially a reduction in efficacy.
Ponatinib Cholesterol may increase the excretion rate of Ponatinib which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Cholesterol may increase the excretion rate of Dabrafenib which could result in a lower serum level and potentially a reduction in efficacy.
Afatinib Cholesterol may increase the excretion rate of Afatinib which could result in a lower serum level and potentially a reduction in efficacy.
Dolutegravir Cholesterol may increase the excretion rate of Dolutegravir which could result in a lower serum level and potentially a reduction in efficacy.
Sofosbuvir Cholesterol may increase the excretion rate of Sofosbuvir which could result in a lower serum level and potentially a reduction in efficacy.
Idelalisib Cholesterol may increase the excretion rate of Idelalisib which could result in a lower serum level and potentially a reduction in efficacy.
Palbociclib Cholesterol may increase the excretion rate of Palbociclib which could result in a lower serum level and potentially a reduction in efficacy.
Lenvatinib Cholesterol may increase the excretion rate of Lenvatinib which could result in a lower serum level and potentially a reduction in efficacy.
Ombitasvir Cholesterol may increase the excretion rate of Ombitasvir which could result in a lower serum level and potentially a reduction in efficacy.
Tenofovir alafenamide Cholesterol may increase the excretion rate of Tenofovir alafenamide which could result in a lower serum level and potentially a reduction in efficacy.
Osimertinib Cholesterol may increase the excretion rate of Osimertinib which could result in a lower serum level and potentially a reduction in efficacy.
Venetoclax Cholesterol may increase the excretion rate of Venetoclax which could result in a lower serum level and potentially a reduction in efficacy.
Velpatasvir Cholesterol may increase the excretion rate of Velpatasvir which could result in a lower serum level and potentially a reduction in efficacy.
Talazoparib Cholesterol may increase the excretion rate of Talazoparib which could result in a lower serum level and potentially a reduction in efficacy.
Revefenacin Cholesterol may increase the excretion rate of Revefenacin which could result in a lower serum level and potentially a reduction in efficacy.
Duvelisib Cholesterol may increase the excretion rate of Duvelisib which could result in a lower serum level and potentially a reduction in efficacy.
Dacomitinib Cholesterol may increase the excretion rate of Dacomitinib which could result in a lower serum level and potentially a reduction in efficacy.
Glasdegib Cholesterol may increase the excretion rate of Glasdegib which could result in a lower serum level and potentially a reduction in efficacy.
Abemaciclib Cholesterol may increase the excretion rate of Abemaciclib which could result in a lower serum level and potentially a reduction in efficacy.
Alpelisib Cholesterol may increase the excretion rate of Alpelisib which could result in a lower serum level and potentially a reduction in efficacy.
Voxilaprevir Cholesterol may increase the excretion rate of Voxilaprevir which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Cholesterol may increase the excretion rate of Rucaparib which could result in a lower serum level and potentially a reduction in efficacy.
Copanlisib Cholesterol may increase the excretion rate of Copanlisib which could result in a lower serum level and potentially a reduction in efficacy.
Tazemetostat Cholesterol may increase the excretion rate of Tazemetostat which could result in a lower serum level and potentially a reduction in efficacy.
Darolutamide Cholesterol may increase the excretion rate of Darolutamide which could result in a lower serum level and potentially a reduction in efficacy.
Lusutrombopag Cholesterol may increase the excretion rate of Lusutrombopag which could result in a lower serum level and potentially a reduction in efficacy.
Pibrentasvir Cholesterol may increase the excretion rate of Pibrentasvir which could result in a lower serum level and potentially a reduction in efficacy.
Glecaprevir Cholesterol may increase the excretion rate of Glecaprevir which could result in a lower serum level and potentially a reduction in efficacy.
Ubrogepant Cholesterol may increase the excretion rate of Ubrogepant which could result in a lower serum level and potentially a reduction in efficacy.
Rimegepant Cholesterol may increase the excretion rate of Rimegepant which could result in a lower serum level and potentially a reduction in efficacy.
Ozanimod Cholesterol may increase the excretion rate of Ozanimod which could result in a lower serum level and potentially a reduction in efficacy.
Tucatinib Cholesterol may increase the excretion rate of Tucatinib which could result in a lower serum level and potentially a reduction in efficacy.
Selumetinib Cholesterol may increase the excretion rate of Selumetinib which could result in a lower serum level and potentially a reduction in efficacy.
Pralatrexate Cholesterol may increase the excretion rate of Pralatrexate which could result in a lower serum level and potentially a reduction in efficacy.
Ripretinib Cholesterol may increase the excretion rate of Ripretinib which could result in a lower serum level and potentially a reduction in efficacy.
Fostemsavir Cholesterol may increase the excretion rate of Fostemsavir which could result in a lower serum level and potentially a reduction in efficacy.
Pralsetinib Cholesterol may increase the excretion rate of Pralsetinib which could result in a lower serum level and potentially a reduction in efficacy.
Berotralstat Cholesterol may increase the excretion rate of Berotralstat which could result in a lower serum level and potentially a reduction in efficacy.
Trilaciclib Cholesterol may increase the excretion rate of Trilaciclib which could result in a lower serum level and potentially a reduction in efficacy.
Binimetinib Cholesterol may increase the excretion rate of Binimetinib which could result in a lower serum level and potentially a reduction in efficacy.
Cladribine The excretion of Cladribine can be increased when combined with Cholesterol.

Target Protein

Choline-phosphate cytidylyltransferase B PCYT1B
Nuclear receptor subfamily 1 group I member 3 NR1I3
Vitamin D3 receptor VDR
C-type lectin domain family 4 member E CLEC4E
Nuclear receptor ROR-alpha RORA

Referensi & Sumber

Synthesis reference: Tatu Miettenen, Ingmar Wester, Hannu Vanhanen, "Substance for lowering high cholesterol level in serum and methods for preparing and using the same." U.S. Patent US6174560, issued February, 1944.

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