Geneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells. Resistance to Geneticin is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Succinylcholine | The therapeutic efficacy of Succinylcholine can be increased when used in combination with Geneticin. |
| Metocurine iodide | The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Geneticin. |
| Gallamine triethiodide | The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Geneticin. |
| Cisatracurium | Geneticin may increase the neuromuscular blocking activities of Cisatracurium. |
| Rocuronium | The therapeutic efficacy of Rocuronium can be increased when used in combination with Geneticin. |
| Atracurium besylate | The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Geneticin. |
| Doxacurium | The therapeutic efficacy of Doxacurium can be increased when used in combination with Geneticin. |
| Mivacurium | The therapeutic efficacy of Mivacurium can be increased when used in combination with Geneticin. |
| Decamethonium | The therapeutic efficacy of Decamethonium can be increased when used in combination with Geneticin. |
| Metocurine | The therapeutic efficacy of Metocurine can be increased when used in combination with Geneticin. |
| Pancuronium | The therapeutic efficacy of Pancuronium can be increased when used in combination with Geneticin. |
| Pipecuronium | The therapeutic efficacy of Pipecuronium can be increased when used in combination with Geneticin. |
| Vecuronium | The therapeutic efficacy of Vecuronium can be increased when used in combination with Geneticin. |
| Rapacuronium | The therapeutic efficacy of Rapacuronium can be increased when used in combination with Geneticin. |
| Pyrantel | The therapeutic efficacy of Pyrantel can be increased when used in combination with Geneticin. |
| Neosaxitoxin | The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Geneticin. |
| Atracurium | The therapeutic efficacy of Atracurium can be increased when used in combination with Geneticin. |
| Gallamine | The therapeutic efficacy of Gallamine can be increased when used in combination with Geneticin. |
| Alcuronium | The therapeutic efficacy of Alcuronium can be increased when used in combination with Geneticin. |
| Tubocurarine | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Geneticin. |
| Carboplatin | The risk or severity of ototoxicity and nephrotoxicity can be increased when Geneticin is combined with Carboplatin. |
| Foscarnet | The risk or severity of nephrotoxicity can be increased when Geneticin is combined with Foscarnet. |
| Mannitol | The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Geneticin. |
| Tenofovir disoproxil | Geneticin may increase the nephrotoxic activities of Tenofovir disoproxil. |
| Tenofovir alafenamide | Geneticin may increase the nephrotoxic activities of Tenofovir alafenamide. |
| Tenofovir | Geneticin may increase the nephrotoxic activities of Tenofovir. |
| Picosulfuric acid | The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Geneticin. |
| Zoledronic acid | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Zoledronic acid. |
| Alendronic acid | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Alendronic acid. |
| Ibandronate | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Ibandronate. |
| Clodronic acid | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Clodronic acid. |
| Risedronic acid | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Risedronic acid. |
| Etidronic acid | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Etidronic acid. |
| Incadronic acid | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Incadronic acid. |
| Pamidronic acid | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Pamidronic acid. |
| Tiludronic acid | The risk or severity of nephrotoxicity and hypocalcemia can be increased when Geneticin is combined with Tiludronic acid. |
| Cyclosporine | The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Geneticin. |
| Icosapent | The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Geneticin. |
| Cefotiam | The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Geneticin. |
| Mesalazine | The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Geneticin. |
| Cefmenoxime | The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Geneticin. |
| Cefmetazole | The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Geneticin. |
| Indomethacin | The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Geneticin. |
| Cidofovir | The risk or severity of nephrotoxicity can be increased when Cidofovir is combined with Geneticin. |
| Triamterene | The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Geneticin. |
| Cefpiramide | The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Geneticin. |
| Ceftazidime | The risk or severity of nephrotoxicity can be increased when Ceftazidime is combined with Geneticin. |
| Loracarbef | The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Geneticin. |
| Framycetin | The risk or severity of nephrotoxicity can be increased when Framycetin is combined with Geneticin. |
| Cefalotin | The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Geneticin. |
| Nabumetone | The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Geneticin. |
| Ketorolac | The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Geneticin. |
| Tenoxicam | The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Geneticin. |
| Celecoxib | The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Geneticin. |
| Cefotaxime | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Geneticin. |
| Tolmetin | The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Geneticin. |
| Rofecoxib | The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Geneticin. |
| Piroxicam | The risk or severity of nephrotoxicity can be increased when Piroxicam is combined with Geneticin. |
| Methotrexate | The risk or severity of nephrotoxicity can be increased when Methotrexate is combined with Geneticin. |
| Cephalexin | The risk or severity of nephrotoxicity can be increased when Cephalexin is combined with Geneticin. |
| Fenoprofen | The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Geneticin. |
| Valaciclovir | The risk or severity of nephrotoxicity can be increased when Valaciclovir is combined with Geneticin. |
| Valdecoxib | The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Geneticin. |
| Diclofenac | The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Geneticin. |
| Sulindac | The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Geneticin. |
| Bacitracin | The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Geneticin. |
| Amphotericin B | The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Geneticin. |
| Cephaloglycin | The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Geneticin. |
| Flurbiprofen | The risk or severity of nephrotoxicity can be increased when Flurbiprofen is combined with Geneticin. |
| Adefovir dipivoxil | The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Geneticin. |
| Pentamidine | The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Geneticin. |
| Etodolac | The risk or severity of nephrotoxicity can be increased when Etodolac is combined with Geneticin. |
| Mefenamic acid | The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Geneticin. |
| Acyclovir | The risk or severity of nephrotoxicity can be increased when Acyclovir is combined with Geneticin. |
| Naproxen | The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Geneticin. |
| Sulfasalazine | The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Geneticin. |
| Phenylbutazone | The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Geneticin. |
| Meloxicam | The risk or severity of methemoglobinemia can be increased when Geneticin is combined with Meloxicam. |
| Carprofen | The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Geneticin. |
| Cefaclor | The risk or severity of nephrotoxicity can be increased when Cefaclor is combined with Geneticin. |
| Diflunisal | The risk or severity of nephrotoxicity can be increased when Diflunisal is combined with Geneticin. |
| Tacrolimus | The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Geneticin. |
| Ceforanide | The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Geneticin. |
| Salicylic acid | The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Geneticin. |
| Meclofenamic acid | The risk or severity of nephrotoxicity can be increased when Meclofenamic acid is combined with Geneticin. |
| Acetylsalicylic acid | The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Geneticin. |
| Oxaprozin | The risk or severity of nephrotoxicity can be increased when Oxaprozin is combined with Geneticin. |
| Hydrochlorothiazide | The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Geneticin. |
| Ketoprofen | The risk or severity of nephrotoxicity can be increased when Ketoprofen is combined with Geneticin. |
| Balsalazide | The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Geneticin. |
| Ibuprofen | The risk or severity of nephrotoxicity can be increased when Ibuprofen is combined with Geneticin. |
| Cefditoren | The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Geneticin. |
| Atazanavir | The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Geneticin. |
| Colistimethate | The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Geneticin. |
| Cefuroxime | The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Geneticin. |
| Cefapirin | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Geneticin. |
| Cefadroxil | The risk or severity of nephrotoxicity can be increased when Cefadroxil is combined with Geneticin. |
| Cefprozil | The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Geneticin. |
| Ceftriaxone | The risk or severity of nephrotoxicity can be increased when Ceftriaxone is combined with Geneticin. |
| Olsalazine | The risk or severity of nephrotoxicity can be increased when Geneticin is combined with Olsalazine. |