Peringatan Keamanan

In rat, oral LD50 74 g/kg and intravenous LD50 is 2.4 mg/kg L2896. Dermal LD50 in guinea pig was >3000 mg/kg L2896.

Oleic Acid

DB04224

small molecule approved investigational vet_approved

Deskripsi

An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)

Struktur Molekul 2D

Berat 282.4614
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic data available.
Volume Distribusi Radio-labelled oleic acid was detected in the heart, liver, lung, spleen, kidney, muscle, intestine, adrenal, blood, and lymph, and adipose, mucosal, and dental tissues [L2896]. Oleic acid is primarily transported via the lymphatic system [L2896].
Klirens (Clearance) No pharmacokinetic data available.

Absorpsi

Fatty acid uptake by different tissues may be mediated via passive diffusion to facilitated diffusion or a combination of both L2896. Fatty acids taken up by tissues are then stored in the form of triglycerides or oxidized L2896. Oleic acid was shown to penetrate rat skin L2896. Following oral administration of Brucea javanica oil emulsion in rats, the time of oleic acid to reach peak plasma concentration was approximately 15.6 hours A33178.

Metabolisme

Like most fatty acids, oleic acid may undergo oxidation via beta-oxidation and tricarboxylic acid cycle pathways of catabolism, where an additional isomerization reaction is required for the complete catabolism of oleic acid. Via a series of elongation and desaturation steps, oleic acid may be converted into longer chain eicosatrienoic and nervonic acid L2896.

Rute Eliminasi

Following oral administration of trace amounts of oleic acid, less than 10% of total oleic acid was found to be eliminated via fecal excretion L2896.

Interaksi Obat

0 Data
Tidak ada data.

Target Protein

Fatty acid-binding protein, adipocyte FABP4
Fatty acid-binding protein, liver FABP1
Peroxisome proliferator-activated receptor alpha PPARA
Peroxisome proliferator-activated receptor delta PPARD
Retinoic acid receptor RXR-alpha RXRA
Peroxisome proliferator-activated receptor gamma PPARG
Myelin P2 protein PMP2

Referensi & Sumber

Synthesis reference: Ansgar Behler, Hermann Anzinger, Michael Vogt, "Process for the preparation of light-colored oleic acid sulfonates." U.S. Patent US5294726, issued June, 1972.
Artikel (PubMed)
  • PMID: -
    Su H, Zhang Y, Huang W, Wen L, Zhuang Z, Chen G: Pharmacokinetics and Tissue Distribution of Oleic and Linoleic Acids Following Oral and Rectal Administration of Brucea javanica Oil in Rats International Journal of Pharmacology. 2016 January 1;12(5):461-482.

Contoh Produk & Brand

Produk: 6 • International brands: 0
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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