Quercetin

DB04216

small molecule experimental investigational

Deskripsi

Quercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.

Struktur Molekul 2D

Berat 302.2357
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

557 Data
Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Quercetin.
Pipamperone The therapeutic efficacy of Pipamperone can be decreased when used in combination with Quercetin.
Tolcapone The metabolism of Quercetin can be decreased when combined with Tolcapone.
Entacapone The metabolism of Quercetin can be decreased when combined with Entacapone.
3,5-Dinitrocatechol The metabolism of Quercetin can be decreased when combined with 3,5-Dinitrocatechol.
Norepinephrine The metabolism of Norepinephrine can be decreased when combined with Quercetin.
Epinephrine The metabolism of Epinephrine can be decreased when combined with Quercetin.
Dobutamine The metabolism of Dobutamine can be decreased when combined with Quercetin.
Methyldopa The metabolism of Methyldopa can be decreased when combined with Quercetin.
Dopamine The metabolism of Dopamine can be decreased when combined with Quercetin.
Micafungin The metabolism of Micafungin can be decreased when combined with Quercetin.
Echinacoside The metabolism of Echinacoside can be decreased when combined with Quercetin.
Testosterone propionate The metabolism of Quercetin can be decreased when combined with Testosterone propionate.
Isoprenaline The metabolism of Isoprenaline can be decreased when combined with Quercetin.
Tranylcypromine The risk or severity of adverse effects can be increased when Quercetin is combined with Tranylcypromine.
Phenelzine The risk or severity of adverse effects can be increased when Quercetin is combined with Phenelzine.
Isocarboxazid The risk or severity of adverse effects can be increased when Quercetin is combined with Isocarboxazid.
Iproniazid The risk or severity of adverse effects can be increased when Quercetin is combined with Iproniazid.
Nialamide The risk or severity of adverse effects can be increased when Quercetin is combined with Nialamide.
Safrazine The risk or severity of adverse effects can be increased when Quercetin is combined with Safrazine.
Folic acid Quercetin may decrease the excretion rate of Folic acid which could result in a higher serum level.
Allopurinol Quercetin may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Raloxifene Quercetin may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Celecoxib Quercetin may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Oxaliplatin Quercetin may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Testosterone Quercetin may decrease the excretion rate of Testosterone which could result in a higher serum level.
Clofarabine Quercetin may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Nitrofurantoin Quercetin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Riluzole Quercetin may decrease the excretion rate of Riluzole which could result in a higher serum level.
Sulfasalazine Quercetin may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Glyburide Quercetin may decrease the excretion rate of Glyburide which could result in a higher serum level.
Tegaserod Quercetin may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Leflunomide Quercetin may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Rosuvastatin Quercetin may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Alvocidib Quercetin may decrease the excretion rate of Alvocidib which could result in a higher serum level.
Teriflunomide Quercetin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Riociguat Quercetin may decrease the excretion rate of Riociguat which could result in a higher serum level.
Palbociclib Quercetin may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Fimasartan Quercetin may decrease the excretion rate of Fimasartan which could result in a higher serum level.
Delafloxacin Quercetin may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Quercetin.
Glasdegib Quercetin may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Testosterone cypionate Quercetin may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.
Testosterone enanthate Quercetin may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.
Darolutamide Quercetin may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Tazemetostat Quercetin may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Vincristine Quercetin may decrease the excretion rate of Vincristine which could result in a higher serum level.
Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Quercetin.
Topotecan Quercetin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Afatinib Quercetin may decrease the excretion rate of Afatinib which could result in a higher serum level.
Conjugated estrogens Quercetin may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Pravastatin Quercetin may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Gefitinib Quercetin may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Cerivastatin Quercetin may decrease the excretion rate of Cerivastatin which could result in a higher serum level.
Teniposide The metabolism of Teniposide can be decreased when combined with Quercetin.
Prazosin Quercetin may decrease the excretion rate of Prazosin which could result in a higher serum level.
Zidovudine Quercetin may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Ritonavir Quercetin may decrease the excretion rate of Ritonavir which could result in a higher serum level.
Methotrexate Quercetin may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Ivermectin Quercetin may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Imatinib Quercetin may decrease the excretion rate of Imatinib which could result in a higher serum level.
Sumatriptan Quercetin may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Quercetin.
Mycophenolate mofetil Quercetin may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
Daunorubicin Quercetin may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Lamivudine Quercetin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Irinotecan Quercetin may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Etoposide The metabolism of Etoposide can be decreased when combined with Quercetin.
Donepezil Quercetin may decrease the excretion rate of Donepezil which could result in a higher serum level.
Dactinomycin Quercetin may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Ezetimibe Quercetin may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Mitoxantrone Quercetin may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Dasatinib The metabolism of Dasatinib can be decreased when combined with Quercetin.
Camptothecin Quercetin may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Nilotinib Quercetin may decrease the excretion rate of Nilotinib which could result in a higher serum level.
Rivaroxaban Quercetin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Simeprevir Quercetin may decrease the excretion rate of Simeprevir which could result in a higher serum level.
Apixaban Quercetin may decrease the excretion rate of Apixaban which could result in a higher serum level.
Vemurafenib Quercetin may decrease the excretion rate of Vemurafenib which could result in a higher serum level.
Dolutegravir Quercetin may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Sofosbuvir Quercetin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Idelalisib Quercetin may decrease the excretion rate of Idelalisib which could result in a higher serum level.
Lenvatinib Quercetin may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Ombitasvir Quercetin may decrease the excretion rate of Ombitasvir which could result in a higher serum level.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Quercetin.
Osimertinib Quercetin may decrease the excretion rate of Osimertinib which could result in a higher serum level.
Venetoclax Quercetin may decrease the excretion rate of Venetoclax which could result in a higher serum level.
Velpatasvir Quercetin may decrease the excretion rate of Velpatasvir which could result in a higher serum level.
Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Quercetin.
Duvelisib Quercetin may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Abemaciclib Quercetin may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Voxilaprevir Quercetin may decrease the excretion rate of Voxilaprevir which could result in a higher serum level.
Rucaparib Quercetin may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Copanlisib Quercetin may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Lusutrombopag Quercetin may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Pibrentasvir Quercetin may decrease the excretion rate of Pibrentasvir which could result in a higher serum level.
Glecaprevir Quercetin may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Tucatinib Quercetin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Selumetinib Quercetin may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Pralatrexate Quercetin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.

Target Protein

Signal transducer and activator of transcription 3 STAT3
Lysophosphatidylcholine acyltransferase 2 LPCAT2
Lysophosphatidylcholine acyltransferase 1 LPCAT1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG
UDP-glucuronosyltransferase 3A1 UGT3A1
ATP synthase subunit alpha, mitochondrial ATP5F1A
ATP synthase subunit beta, mitochondrial ATP5F1B
ATP synthase subunit gamma, mitochondrial ATP5F1C
Serine/threonine-protein kinase pim-1 PIM1
HTH-type transcriptional regulator TtgR ttgR
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ fabZ
Serine/threonine-protein kinase 17B STK17B
Estrogen receptor ESR1
Estrogen receptor beta ESR2
Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2
Aryl hydrocarbon receptor AHR
Cytochrome P450 1B1 CYP1B1
Actin, cytoplasmic 1 ACTB
Casein kinase II subunit alpha CSNK2A1
Casein kinase II subunit beta CSNK2B
Eukaryotic translation initiation factor 3 subunit F EIF3F
Heat shock protein HSP 90-alpha HSP90AA1
Heat shock-related 70 kDa protein 2 HSPA2
RuvB-like 2 RUVBL2
Splicing factor 3B subunit 3 SF3B3
Ubiquitin-like modifier-activating enzyme 1 UBA1
Sex hormone-binding globulin SHBG
Carbonyl reductase [NADPH] 1 CBR1
CCAAT/enhancer-binding protein beta CEBPB
Nuclear receptor subfamily 1 group I member 2 NR1I2
Tyrosine-protein kinase HCK HCK

Referensi & Sumber

Synthesis reference: Miguel M. Taya, Dionisio M. Aedo, Rene Ricard, "Quercetin pentamethyl carbamate and a process for its preparation." U.S. Patent US4202825, issued October, 1975.

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Sekuens Gen/Protein (FASTA)

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