Clorobiocin

DB03966

small molecule experimental

Deskripsi

Clorobiocin is an aminocoumarin antibiotic, similar to novobiocin and coumermycin A1.

Struktur Molekul 2D

Berat 697.128
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

17 Data
Dexmethylphenidate The serum concentration of the active metabolites of Clorobiocin can be increased when Clorobiocin is used in combination with Dexmethylphenidate.
Glimepiride The therapeutic efficacy of Glimepiride can be increased when used in combination with Clorobiocin.
Acetohexamide The therapeutic efficacy of Acetohexamide can be increased when used in combination with Clorobiocin.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Clorobiocin.
Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Clorobiocin.
Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Clorobiocin.
Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Clorobiocin.
Gliclazide The therapeutic efficacy of Gliclazide can be increased when used in combination with Clorobiocin.
Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Clorobiocin.
Gliquidone The therapeutic efficacy of Gliquidone can be increased when used in combination with Clorobiocin.
Glisoxepide The therapeutic efficacy of Glisoxepide can be increased when used in combination with Clorobiocin.
Glibornuride The therapeutic efficacy of Glibornuride can be increased when used in combination with Clorobiocin.
Carbutamide The therapeutic efficacy of Carbutamide can be increased when used in combination with Clorobiocin.
Metahexamide The therapeutic efficacy of Metahexamide can be increased when used in combination with Clorobiocin.
Lepirudin The risk or severity of bleeding can be increased when Clorobiocin is combined with Lepirudin.
Doxycycline The therapeutic efficacy of Clorobiocin can be increased when used in combination with Doxycycline.
Diazoxide The serum concentration of Clorobiocin can be increased when it is combined with Diazoxide.

Target Protein

DNA topoisomerase 2-beta TOP2B
DNA topoisomerase 2-alpha TOP2A
DNA gyrase subunit B gyrB

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9144789
    Tsai FT, Singh OM, Skarzynski T, Wonacott AJ, Weston S, Tucker A, Pauptit RA, Breeze AL, Poyser JP, O'Brien R, Ladbury JE, Wigley DB: The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins. 1997 May;28(1):41-52.
  • PMID: 7050623
    Cejka K, Holubova I, Hubacek J: Curing effect of clorobiocin on Escherichia coli plasmids. Mol Gen Genet. 1982;186(1):153-5.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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