Benzoic acid

DB03793

small molecule approved investigational

Deskripsi

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.

Struktur Molekul 2D

Berat 122.123
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

145 Data
Succinic acid The excretion of Succinic acid can be decreased when combined with Benzoic acid.
Citrulline The excretion of Citrulline can be decreased when combined with Benzoic acid.
Pravastatin The excretion of Pravastatin can be decreased when combined with Benzoic acid.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Benzoic acid.
Cefotiam The excretion of Cefotiam can be decreased when combined with Benzoic acid.
Conjugated estrogens The excretion of Conjugated estrogens can be decreased when combined with Benzoic acid.
Tenofovir disoproxil The excretion of Tenofovir disoproxil can be decreased when combined with Benzoic acid.
Piperacillin The excretion of Piperacillin can be decreased when combined with Benzoic acid.
Indomethacin The excretion of Indomethacin can be decreased when combined with Benzoic acid.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Benzoic acid.
Trifluridine The excretion of Trifluridine can be decreased when combined with Benzoic acid.
Allopurinol The excretion of Allopurinol can be decreased when combined with Benzoic acid.
Zidovudine The excretion of Zidovudine can be decreased when combined with Benzoic acid.
Cimetidine The excretion of Cimetidine can be decreased when combined with Benzoic acid.
Cefdinir The excretion of Cefdinir can be decreased when combined with Benzoic acid.
Methotrexate The excretion of Methotrexate can be decreased when combined with Benzoic acid.
Cephalexin The excretion of Cephalexin can be decreased when combined with Benzoic acid.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Benzoic acid.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Benzoic acid.
Leucovorin The excretion of Leucovorin can be decreased when combined with Benzoic acid.
Fluorescein The excretion of Fluorescein can be decreased when combined with Benzoic acid.
Tetracycline The excretion of Tetracycline can be decreased when combined with Benzoic acid.
Estradiol The excretion of Estradiol can be decreased when combined with Benzoic acid.
Acyclovir The excretion of Acyclovir can be decreased when combined with Benzoic acid.
Cefaclor The excretion of Cefaclor can be decreased when combined with Benzoic acid.
Ranitidine The excretion of Ranitidine can be decreased when combined with Benzoic acid.
Quinapril The excretion of Quinapril can be decreased when combined with Benzoic acid.
Bumetanide The excretion of Bumetanide can be decreased when combined with Benzoic acid.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Benzoic acid.
Famotidine The excretion of Famotidine can be decreased when combined with Benzoic acid.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Benzoic acid.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Benzoic acid.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Benzoic acid.
Captopril The excretion of Captopril can be decreased when combined with Benzoic acid.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Benzoic acid.
Cefazolin The excretion of Cefazolin can be decreased when combined with Benzoic acid.
Ceftizoxime The excretion of Ceftizoxime can be decreased when combined with Benzoic acid.
Cefacetrile The excretion of Cefacetrile can be decreased when combined with Benzoic acid.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Benzoic acid.
Tazobactam The excretion of Tazobactam can be decreased when combined with Benzoic acid.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Benzoic acid.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Benzoic acid.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Benzoic acid.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Benzoic acid.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Benzoic acid.
Doripenem The excretion of Doripenem can be decreased when combined with Benzoic acid.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Benzoic acid.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Benzoic acid.
Cefaloridine The excretion of Cefaloridine can be decreased when combined with Benzoic acid.
Avibactam The excretion of Avibactam can be decreased when combined with Benzoic acid.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Benzoic acid.
Silibinin The excretion of Silibinin can be decreased when combined with Benzoic acid.
Tenofovir alafenamide The excretion of Tenofovir alafenamide can be decreased when combined with Benzoic acid.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Benzoic acid.
Relebactam The excretion of Relebactam can be decreased when combined with Benzoic acid.
Tenofovir The excretion of Tenofovir can be decreased when combined with Benzoic acid.
Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Benzoic acid.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Benzoic acid.
Polythiazide The excretion of Polythiazide can be decreased when combined with Benzoic acid.
Dexamethasone acetate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Dexamethasone acetate.
Haloperidol The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Haloperidol.
Probenecid The serum concentration of the active metabolites of Benzoic acid can be increased when Benzoic acid is used in combination with Probenecid.
Valproic acid The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Valproic acid.
Hydrocortisone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Hydrocortisone.
Flunisolide The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Flunisolide.
Beclomethasone dipropionate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Beclomethasone dipropionate.
Betamethasone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Betamethasone.
Fluticasone propionate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluticasone propionate.
Fluocinolone acetonide The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluocinolone acetonide.
Triamcinolone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Triamcinolone.
Prednisone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Prednisone.
Fludrocortisone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fludrocortisone.
Prednisolone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Prednisolone.
Methylprednisolone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Methylprednisolone.
Trilostane The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Trilostane.
Budesonide The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Budesonide.
Dexamethasone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Dexamethasone.
Corticotropin The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Corticotropin.
Cortisone acetate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Cortisone acetate.
Paramethasone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Paramethasone.
Ciclesonide The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Ciclesonide.
Aldosterone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Aldosterone.
Fluticasone furoate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluticasone furoate.
Fluprednidene The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluprednidene.
Tixocortol The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Tixocortol.
Fluprednisolone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluprednisolone.
Meprednisone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Meprednisone.
Dexamethasone isonicotinate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Dexamethasone isonicotinate.
Melengestrol The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Melengestrol.
Deflazacort The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Deflazacort.
Cortivazol The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Cortivazol.
Prednylidene The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Prednylidene.
Fluocortin The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluocortin.
Fluperolone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluperolone.
Cloprednol The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Cloprednol.
Fluclorolone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluclorolone.
Fluticasone The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Fluticasone.
Mometasone furoate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Mometasone furoate.
Hydrocortisone acetate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Hydrocortisone acetate.
Hydrocortisone cypionate The therapeutic efficacy of Benzoic acid can be decreased when used in combination with Hydrocortisone cypionate.

Target Protein

Ras-related protein Rab-9A RAB9A
Solute carrier family 15 member 1 SLC15A1
Cocaine esterase cocE
D-amino-acid oxidase DAO
Chlorocatechol 1,2-dioxygenase clcA
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD
Non-heme chloroperoxidase cpo
Oxygen-insensitive NAD(P)H nitroreductase nfsB
Hydroxyquinol 1,2-dioxygenase chqB
Replication protein repA

Referensi & Sumber

Synthesis reference: Ludovicus A. L. Kleintjens, Hubertus M. J. Grooten, "Process for the preparation of benzoic acid." U.S. Patent US4539425, issued March, 1932.

Contoh Produk & Brand

Produk: 36 • International brands: 0
Produk
  • Ammonul
    Injection, solution, concentrate • - • Intravenous • US • Approved
  • Ammonul
    Injection, solution, concentrate • - • Intravenous • US • Approved
  • Ammonul
    Injection, solution, concentrate • - • Intravenous • US • Approved
  • Camphorated Opium Tincture
    Tincture • - • Oral • Canada • Approved
  • Eyelids Wipes
    Cloth • 0.1 g/100g • Topical • US • OTC
  • Glycothymoline
    Liquid • - • Topical • Canada • OTC • Approved
  • HydroGold 9
    Patch • - • Topical • US • OTC
  • Hyophen
    Tablet • - • Oral • US
Menampilkan 8 dari 36 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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