Naringenin

DB03467

small molecule experimental

Deskripsi

Struktur Molekul 2D

Berat 272.2528
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

99 Data
Folic acid Naringenin may decrease the excretion rate of Folic acid which could result in a higher serum level.
Pravastatin Naringenin may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Conjugated estrogens Naringenin may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Gefitinib Naringenin may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Allopurinol Naringenin may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Cerivastatin Naringenin may decrease the excretion rate of Cerivastatin which could result in a higher serum level.
Teniposide Naringenin may decrease the excretion rate of Teniposide which could result in a higher serum level.
Prazosin Naringenin may decrease the excretion rate of Prazosin which could result in a higher serum level.
Raloxifene Naringenin may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Celecoxib Naringenin may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Zidovudine Naringenin may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Ritonavir Naringenin may decrease the excretion rate of Ritonavir which could result in a higher serum level.
Oxaliplatin Naringenin may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Vincristine Naringenin may decrease the excretion rate of Vincristine which could result in a higher serum level.
Fluorouracil Naringenin may decrease the excretion rate of Fluorouracil which could result in a higher serum level.
Methotrexate Naringenin may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Ivermectin Naringenin may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Imatinib Naringenin may decrease the excretion rate of Imatinib which could result in a higher serum level.
Testosterone Naringenin may decrease the excretion rate of Testosterone which could result in a higher serum level.
Clofarabine Naringenin may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Sumatriptan Naringenin may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tamoxifen Naringenin may decrease the excretion rate of Tamoxifen which could result in a higher serum level.
Mycophenolate mofetil Naringenin may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
Daunorubicin Naringenin may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Naringenin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Lamivudine Naringenin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Naringenin may decrease the excretion rate of Riluzole which could result in a higher serum level.
Irinotecan Naringenin may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Etoposide Naringenin may decrease the excretion rate of Etoposide which could result in a higher serum level.
Sulfasalazine Naringenin may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Dactinomycin Naringenin may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Ezetimibe Naringenin may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Doxorubicin Naringenin may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Glyburide Naringenin may decrease the excretion rate of Glyburide which could result in a higher serum level.
Topotecan Naringenin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Tegaserod Naringenin may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Leflunomide Naringenin may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Rosuvastatin Naringenin may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Mitoxantrone Naringenin may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Dasatinib Naringenin may decrease the excretion rate of Dasatinib which could result in a higher serum level.
Alvocidib Naringenin may decrease the excretion rate of Alvocidib which could result in a higher serum level.
Camptothecin Naringenin may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Nilotinib Naringenin may decrease the excretion rate of Nilotinib which could result in a higher serum level.
Rivaroxaban Naringenin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Simeprevir Naringenin may decrease the excretion rate of Simeprevir which could result in a higher serum level.
Pazopanib Naringenin may decrease the excretion rate of Pazopanib which could result in a higher serum level.
Apixaban Naringenin may decrease the excretion rate of Apixaban which could result in a higher serum level.
Teriflunomide Naringenin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Vemurafenib Naringenin may decrease the excretion rate of Vemurafenib which could result in a higher serum level.
Ponatinib Naringenin may decrease the excretion rate of Ponatinib which could result in a higher serum level.
Dabrafenib Naringenin may decrease the excretion rate of Dabrafenib which could result in a higher serum level.
Afatinib Naringenin may decrease the excretion rate of Afatinib which could result in a higher serum level.
Dolutegravir Naringenin may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Riociguat Naringenin may decrease the excretion rate of Riociguat which could result in a higher serum level.
Sofosbuvir Naringenin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Idelalisib Naringenin may decrease the excretion rate of Idelalisib which could result in a higher serum level.
Palbociclib Naringenin may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Lenvatinib Naringenin may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Fimasartan Naringenin may decrease the excretion rate of Fimasartan which could result in a higher serum level.
Ombitasvir Naringenin may decrease the excretion rate of Ombitasvir which could result in a higher serum level.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Naringenin.
Osimertinib Naringenin may decrease the excretion rate of Osimertinib which could result in a higher serum level.
Venetoclax Naringenin may decrease the excretion rate of Venetoclax which could result in a higher serum level.
Velpatasvir Naringenin may decrease the excretion rate of Velpatasvir which could result in a higher serum level.
Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Naringenin.
Revefenacin Naringenin may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Delafloxacin Naringenin may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Duvelisib Naringenin may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Dacomitinib Naringenin may decrease the excretion rate of Dacomitinib which could result in a higher serum level.
Glasdegib Naringenin may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Abemaciclib Naringenin may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Voxilaprevir Naringenin may decrease the excretion rate of Voxilaprevir which could result in a higher serum level.
Brigatinib Naringenin may decrease the excretion rate of Brigatinib which could result in a higher serum level.
Rucaparib Naringenin may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Copanlisib Naringenin may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Lusutrombopag Naringenin may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Enasidenib Naringenin may decrease the excretion rate of Enasidenib which could result in a higher serum level.
Pibrentasvir Naringenin may decrease the excretion rate of Pibrentasvir which could result in a higher serum level.
Glecaprevir Naringenin may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Testosterone cypionate Naringenin may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.
Testosterone enanthate Naringenin may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.
Donepezil Naringenin may decrease the excretion rate of Donepezil which could result in a higher serum level.
Darolutamide Naringenin may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Tazemetostat Naringenin may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Tucatinib Naringenin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Selumetinib Naringenin may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Pralatrexate Naringenin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Ripretinib Naringenin may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Fostemsavir Naringenin may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Pralsetinib Naringenin may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Trilaciclib Naringenin may decrease the excretion rate of Trilaciclib which could result in a higher serum level.
Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Naringenin.
Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Naringenin.
Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Naringenin.
Ozanimod Naringenin may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Berotralstat The serum concentration of Berotralstat can be increased when it is combined with Naringenin.
Binimetinib Naringenin may decrease the excretion rate of Binimetinib which could result in a higher serum level.
Cladribine The excretion of Cladribine can be decreased when combined with Naringenin.
Seladelpar The metabolism of Seladelpar can be decreased when combined with Naringenin.

Target Protein

HTH-type transcriptional regulator TtgR ttgR
Estrogen receptor ESR1
Aldo-keto reductase family 1 member C1 AKR1C1
Cytochrome P450 1B1 CYP1B1
KAT8 regulatory NSL complex subunit 3 KANSL3
Sex hormone-binding globulin SHBG
Aromatase CYP19A1
Estrogen receptor beta ESR2

Referensi & Sumber

Synthesis reference: Heike Wilhelm, Ludger A. Wessojohann, Martin Biendl, "METHOD FOR PRODUCING NARINGENIN DERIVATIVES FROM XANTHOHUMOL." U.S. Patent US20090227806, issued September 10, 2009.

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