Nicotinamide adenine dinucleotide phosphate

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Isocitrate dehydrogenase [NADP] icd

Aldo-keto reductase family 1 member B1 AKR1B1

Glucose-6-phosphate 1-dehydrogenase zwf

Aldo-keto reductase family 1 member C2 AKR1C2

17-beta-hydroxysteroid dehydrogenase type 1 HSD17B1

NAD(P) transhydrogenase, mitochondrial NNT

11-beta-hydroxysteroid dehydrogenase 1 HSD11B1

Sepiapterin reductase SPR

Pteridine reductase 1 PTR1

L-xylulose reductase DCXR

Isocitrate dehydrogenase [NADP] cytoplasmic IDH1

Aldo-keto reductase family 1 member C1 AKR1C1

Nitric oxide synthase 1 NOS1

Glucose-6-phosphate 1-dehydrogenase G6PD

Dihydrofolate reductase DHFR

ADP-L-glycero-D-manno-heptose-6-epimerase hldD

C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1

Aldo-keto reductase family 1 member C3 AKR1C3

Flavin reductase (NADPH) BLVRB

Isocitrate dehydrogenase [NADP] icd

Dihydrofolate reductase

Quinone oxidoreductase CRYZ

3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR

All-trans-retinol dehydrogenase [NAD(+)] ADH1B ADH1B

NADPH--cytochrome P450 reductase POR

Shikimate dehydrogenase (NADP(+)) aroE

NADP-dependent isopropanol dehydrogenase adh

GDP-L-fucose synthase fcl

Aspartate-semialdehyde dehydrogenase asd

2,4-dienoyl-CoA reductase [NADPH] fadH

NADP-dependent malic enzyme ME1

Dihydrofolate reductase folA

NAD(P) transhydrogenase subunit beta pntB

3-oxoacyl-[acyl-carrier-protein] reductase FabG fabG

Dehydrogenase/reductase SDR family member 11 DHRS11

Malate dehydrogenase, cytoplasmic MDH1

Oxidoreductase YdhF ydhF

Putative pteridine reductase 2 ptr2

(3R)-3-hydroxyacyl-CoA dehydrogenase HSD17B8

Aldo-keto reductase family 1 member A1 AKR1A1

Putative ketoacyl reductase actIII

2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial DECR1

Oxidoreductase, short chain dehydrogenase/reductase family

Prostaglandin F synthase

General stress protein 69 yhdN

Ferredoxin--NADP reductase petH

Bifunctional protein MdtA mtdA

Alcohol dehydrogenase, iron-containing

NADPH:adrenodoxin oxidoreductase, mitochondrial FDXR

Ferredoxin--NADP reductase petH

2,5-diketo-D-gluconic acid reductase A dkgA

Protein IolS iolS

NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN

Prostaglandin reductase 1 PTGR1

Sulfite reductase [NADPH] flavoprotein alpha-component cysJ

Aldo-keto reductase family 1 member B10 AKR1B10

NADH-dependent butanol dehydrogenase A

NADP-dependent fatty aldehyde dehydrogenase aldH

Putative dehydrogenase/reductase SDR family member 4-like 1 DHRS4L1

Oxidoreductase, aldo/keto reductase family

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.