Acetylcholine

DB03128

small molecule approved investigational

Deskripsi

A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.

Struktur Molekul 2D

Berat 146.2074
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

170 Data
Esmolol The risk or severity of adverse effects can be increased when Esmolol is combined with Acetylcholine.
Betaxolol The risk or severity of adverse effects can be increased when Betaxolol is combined with Acetylcholine.
Metoprolol The risk or severity of adverse effects can be increased when Metoprolol is combined with Acetylcholine.
Atenolol The risk or severity of adverse effects can be increased when Atenolol is combined with Acetylcholine.
Timolol The risk or severity of adverse effects can be increased when Timolol is combined with Acetylcholine.
Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Acetylcholine.
Propranolol The risk or severity of adverse effects can be increased when Propranolol is combined with Acetylcholine.
Labetalol The risk or severity of adverse effects can be increased when Labetalol is combined with Acetylcholine.
Bisoprolol The risk or severity of adverse effects can be increased when Bisoprolol is combined with Acetylcholine.
Alprenolol The risk or severity of adverse effects can be increased when Alprenolol is combined with Acetylcholine.
Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Acetylcholine.
Carvedilol The risk or severity of adverse effects can be increased when Carvedilol is combined with Acetylcholine.
Propafenone The risk or severity of adverse effects can be increased when Propafenone is combined with Acetylcholine.
Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Acetylcholine.
Nadolol The risk or severity of adverse effects can be increased when Nadolol is combined with Acetylcholine.
Bevantolol The risk or severity of adverse effects can be increased when Bevantolol is combined with Acetylcholine.
Practolol The risk or severity of adverse effects can be increased when Practolol is combined with Acetylcholine.
Penbutolol The risk or severity of adverse effects can be increased when Penbutolol is combined with Acetylcholine.
Oxprenolol The risk or severity of adverse effects can be increased when Oxprenolol is combined with Acetylcholine.
Dexpropranolol The risk or severity of adverse effects can be increased when Dexpropranolol is combined with Acetylcholine.
Celiprolol The risk or severity of adverse effects can be increased when Celiprolol is combined with Acetylcholine.
Nebivolol The risk or severity of adverse effects can be increased when Nebivolol is combined with Acetylcholine.
Bufuralol The risk or severity of adverse effects can be increased when Bufuralol is combined with Acetylcholine.
Bopindolol The risk or severity of adverse effects can be increased when Bopindolol is combined with Acetylcholine.
Bupranolol The risk or severity of adverse effects can be increased when Bupranolol is combined with Acetylcholine.
Indenolol The risk or severity of adverse effects can be increased when Indenolol is combined with Acetylcholine.
Arotinolol The risk or severity of adverse effects can be increased when Arotinolol is combined with Acetylcholine.
Levobetaxolol The risk or severity of adverse effects can be increased when Levobetaxolol is combined with Acetylcholine.
Talinolol The risk or severity of adverse effects can be increased when Talinolol is combined with Acetylcholine.
Anisodamine The risk or severity of adverse effects can be increased when Anisodamine is combined with Acetylcholine.
Bucindolol The risk or severity of adverse effects can be increased when Bucindolol is combined with Acetylcholine.
Esatenolol The risk or severity of adverse effects can be increased when Esatenolol is combined with Acetylcholine.
Cloranolol The risk or severity of adverse effects can be increased when Cloranolol is combined with Acetylcholine.
Mepindolol The risk or severity of adverse effects can be increased when Mepindolol is combined with Acetylcholine.
Epanolol The risk or severity of adverse effects can be increased when Epanolol is combined with Acetylcholine.
Tertatolol The risk or severity of adverse effects can be increased when Tertatolol is combined with Acetylcholine.
Landiolol The risk or severity of adverse effects can be increased when Landiolol is combined with Acetylcholine.
Cimetropium Acetylcholine may decrease the anticholinergic activities of Cimetropium.
Pegvisomant The risk or severity of adverse effects can be increased when Pegvisomant is combined with Acetylcholine.
Mefloquine The risk or severity of adverse effects can be increased when Mefloquine is combined with Acetylcholine.
Tacrine The risk or severity of adverse effects can be increased when Tacrine is combined with Acetylcholine.
Sulpiride The risk or severity of adverse effects can be increased when Sulpiride is combined with Acetylcholine.
Profenamine The risk or severity of adverse effects can be increased when Profenamine is combined with Acetylcholine.
Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Acetylcholine.
Gallamine triethiodide The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Acetylcholine.
Triflupromazine The risk or severity of adverse effects can be increased when Triflupromazine is combined with Acetylcholine.
Cisplatin The risk or severity of adverse effects can be increased when Cisplatin is combined with Acetylcholine.
Cinchocaine The risk or severity of adverse effects can be increased when Cinchocaine is combined with Acetylcholine.
Pyridostigmine The risk or severity of adverse effects can be increased when Pyridostigmine is combined with Acetylcholine.
Nizatidine The risk or severity of adverse effects can be increased when Nizatidine is combined with Acetylcholine.
Galantamine The risk or severity of adverse effects can be increased when Galantamine is combined with Acetylcholine.
Isoflurophate The risk or severity of adverse effects can be increased when Isoflurophate is combined with Acetylcholine.
Diethylcarbamazine The risk or severity of adverse effects can be increased when Diethylcarbamazine is combined with Acetylcholine.
Procaine The risk or severity of adverse effects can be increased when Procaine is combined with Acetylcholine.
Minaprine The risk or severity of adverse effects can be increased when Minaprine is combined with Acetylcholine.
Terbutaline The risk or severity of adverse effects can be increased when Terbutaline is combined with Acetylcholine.
Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Acetylcholine.
Hexafluronium The risk or severity of adverse effects can be increased when Hexafluronium is combined with Acetylcholine.
Demecarium The risk or severity of adverse effects can be increased when Demecarium is combined with Acetylcholine.
Physostigmine The risk or severity of adverse effects can be increased when Physostigmine is combined with Acetylcholine.
Rivastigmine The risk or severity of adverse effects can be increased when Rivastigmine is combined with Acetylcholine.
Edrophonium The risk or severity of adverse effects can be increased when Edrophonium is combined with Acetylcholine.
Memantine The risk or severity of adverse effects can be increased when Memantine is combined with Acetylcholine.
Ambenonium The risk or severity of adverse effects can be increased when Ambenonium is combined with Acetylcholine.
Tubocurarine The risk or severity of adverse effects can be increased when Tubocurarine is combined with Acetylcholine.
Ketamine The risk or severity of adverse effects can be increased when Ketamine is combined with Acetylcholine.
Metoclopramide The risk or severity of adverse effects can be increased when Metoclopramide is combined with Acetylcholine.
Decamethonium The risk or severity of adverse effects can be increased when Decamethonium is combined with Acetylcholine.
Pipecuronium The risk or severity of adverse effects can be increased when Pipecuronium is combined with Acetylcholine.
Ginkgo biloba The risk or severity of adverse effects can be increased when Ginkgo biloba is combined with Acetylcholine.
Neostigmine The risk or severity of adverse effects can be increased when Neostigmine is combined with Acetylcholine.
Bambuterol The risk or severity of adverse effects can be increased when Bambuterol is combined with Acetylcholine.
1,10-Phenanthroline The risk or severity of adverse effects can be increased when 1,10-Phenanthroline is combined with Acetylcholine.
Thiotepa The risk or severity of adverse effects can be increased when Thiotepa is combined with Acetylcholine.
Huperzine A The risk or severity of adverse effects can be increased when Huperzine A is combined with Acetylcholine.
Phenserine The risk or severity of adverse effects can be increased when Phenserine is combined with Acetylcholine.
Regramostim The risk or severity of adverse effects can be increased when Regramostim is combined with Acetylcholine.
Aprotinin The risk or severity of adverse effects can be increased when Aprotinin is combined with Acetylcholine.
Betaine The risk or severity of adverse effects can be increased when Betaine is combined with Acetylcholine.
Capsaicin The risk or severity of adverse effects can be increased when Capsaicin is combined with Acetylcholine.
Coumaphos The risk or severity of adverse effects can be increased when Coumaphos is combined with Acetylcholine.
Dichlorvos The risk or severity of adverse effects can be increased when Dichlorvos is combined with Acetylcholine.
Fenthion The risk or severity of adverse effects can be increased when Fenthion is combined with Acetylcholine.
Metrifonate The risk or severity of adverse effects can be increased when Metrifonate is combined with Acetylcholine.
Acotiamide The risk or severity of adverse effects can be increased when Acotiamide is combined with Acetylcholine.
Methanesulfonyl Fluoride The risk or severity of adverse effects can be increased when Methanesulfonyl Fluoride is combined with Acetylcholine.
Paraoxon The risk or severity of adverse effects can be increased when Paraoxon is combined with Acetylcholine.
Tyrothricin The risk or severity of adverse effects can be increased when Tyrothricin is combined with Acetylcholine.
Ipidacrine The risk or severity of adverse effects can be increased when Ipidacrine is combined with Acetylcholine.
Distigmine The risk or severity of adverse effects can be increased when Distigmine is combined with Acetylcholine.
Tretamine The risk or severity of adverse effects can be increased when Tretamine is combined with Acetylcholine.
Posiphen The risk or severity of adverse effects can be increased when Posiphen is combined with Acetylcholine.
Methylphosphinic Acid The risk or severity of adverse effects can be increased when Methylphosphinic Acid is combined with Acetylcholine.
Patent Blue The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Patent Blue.
Capreomycin The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Capreomycin.
Framycetin The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Framycetin.
Amikacin The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Amikacin.
Tobramycin The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Tobramycin.
Gentamicin The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Gentamicin.
Netilmicin The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Netilmicin.

Target Protein

Muscarinic acetylcholine receptor M1 CHRM1
Muscarinic acetylcholine receptor M2 CHRM2
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M4 CHRM4
Neuronal acetylcholine receptor subunit alpha-7 CHRNA7

Referensi & Sumber

Synthesis reference: Masao Tanihara, Hideaki Yamada, Toshihide Nakashima, Yoshiaki Omura, Koichi Takakura, "Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody." U.S. Patent US5192684, issued December, 1984.

Contoh Produk & Brand

Produk: 5 • International brands: 0
Produk
  • Miochol E
    Kit • 20 mg/2mL • Intraocular • US • Approved
  • Miochol E
    Kit; Solution • 20 mg/2mL • Intraocular • US • Approved
  • Miochol E Acetylcholine Chloride Oph Soln
    Powder, for solution • 10 mg / mL • Ophthalmic • Canada • Approved
  • Miochol-E
    Powder, for solution • 20 mg / vial • Ophthalmic • Canada • Approved
  • Miogan Pws 20mg/vial
    Powder, for solution • 20 mg / vial • Intraocular • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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