Resveratrol

DB02709

small molecule investigational

Deskripsi

Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic phytoalexin. It is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. It exists as cis-(Z) and trans-(E) isomers. The trans- form can undergo isomerisation to the cis- form when heated or exposed to ultraviolet irradiation. In a 2004 issue of Science, Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. It has been claimed that it is readily degraded by exposure to light, heat, and oxygen. However, studies find that Trans-resveratrol undergoes negligible oxidation in normal atmosphere at room temperature.

Struktur Molekul 2D

Berat 228.2433
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

High absorption but very low bioavailability.

Metabolisme

Hepatic. Rapidly metabolized and excreted.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

432 Data
Apixaban The risk or severity of adverse effects can be increased when Resveratrol is combined with Apixaban.
Dasatinib Dasatinib may increase the anticoagulant activities of Resveratrol.
Ursodeoxycholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Cholic Acid.
Glycocholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Taurocholic acid.
Obeticholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of adverse effects can be increased when Resveratrol is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of adverse effects can be increased when Resveratrol is combined with Hyodeoxycholic Acid.
Glucosamine Glucosamine may increase the antiplatelet activities of Resveratrol.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Resveratrol is combined with Ibritumomab tiuxetan.
Obinutuzumab The risk or severity of adverse effects can be increased when Resveratrol is combined with Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the antiplatelet activities of Resveratrol.
Rivaroxaban Resveratrol may increase the anticoagulant activities of Rivaroxaban.
Tipranavir Tipranavir may increase the antiplatelet activities of Resveratrol.
Urokinase Resveratrol may increase the anticoagulant activities of Urokinase.
Vitamin E Vitamin E may increase the antiplatelet activities of Resveratrol.
Ibrutinib The risk or severity of adverse effects can be increased when Ibrutinib is combined with Resveratrol.
Cilostazol Cilostazol may increase the antiplatelet activities of Resveratrol.
Tofacitinib The risk or severity of bleeding can be increased when Resveratrol is combined with Tofacitinib.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Resveratrol.
Warfarin The risk or severity of bleeding can be increased when Resveratrol is combined with Warfarin.
Acenocoumarol The risk or severity of bleeding can be increased when Resveratrol is combined with Acenocoumarol.
(R)-warfarin The risk or severity of bleeding can be increased when Resveratrol is combined with (R)-warfarin.
(S)-Warfarin The risk or severity of bleeding can be increased when Resveratrol is combined with (S)-Warfarin.
Tacrolimus The risk or severity of bleeding can be increased when Resveratrol is combined with Tacrolimus.
Pentosan polysulfate The risk or severity of adverse effects can be increased when Pentosan polysulfate is combined with Resveratrol.
Limaprost Limaprost may increase the antiplatelet activities of Resveratrol.
Omega-3 fatty acids Omega-3 fatty acids may increase the antiplatelet activities of Resveratrol.
Tositumomab The risk or severity of adverse effects can be increased when Resveratrol is combined with Tositumomab.
Pamidronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Pamidronic acid.
Zoledronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Zoledronic acid.
Alendronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Alendronic acid.
Ibandronate The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Ibandronate.
Clodronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Clodronic acid.
Risedronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Risedronic acid.
Etidronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Etidronic acid.
Tiludronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Tiludronic acid.
Incadronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Resveratrol is combined with Incadronic acid.
Lepirudin The risk or severity of bleeding can be increased when Resveratrol is combined with Lepirudin.
Bivalirudin The risk or severity of bleeding can be increased when Resveratrol is combined with Bivalirudin.
Alteplase The risk or severity of bleeding can be increased when Resveratrol is combined with Alteplase.
Reteplase The risk or severity of bleeding can be increased when Resveratrol is combined with Reteplase.
Anistreplase The risk or severity of bleeding can be increased when Resveratrol is combined with Anistreplase.
Tenecteplase The risk or severity of bleeding can be increased when Resveratrol is combined with Tenecteplase.
Abciximab The risk or severity of bleeding can be increased when Resveratrol is combined with Abciximab.
Drotrecogin alfa The risk or severity of bleeding can be increased when Resveratrol is combined with Drotrecogin alfa.
Streptokinase The risk or severity of bleeding can be increased when Resveratrol is combined with Streptokinase.
Dicoumarol The risk or severity of bleeding can be increased when Resveratrol is combined with Dicoumarol.
Argatroban The risk or severity of bleeding can be increased when Resveratrol is combined with Argatroban.
Ardeparin The risk or severity of bleeding can be increased when Resveratrol is combined with Ardeparin.
Phenindione The risk or severity of bleeding can be increased when Resveratrol is combined with Phenindione.
Fondaparinux The risk or severity of bleeding can be increased when Resveratrol is combined with Fondaparinux.
Phenprocoumon The risk or severity of bleeding can be increased when Resveratrol is combined with Phenprocoumon.
Dipyridamole The risk or severity of bleeding can be increased when Resveratrol is combined with Dipyridamole.
Heparin The risk or severity of bleeding can be increased when Resveratrol is combined with Heparin.
Enoxaparin The risk or severity of bleeding can be increased when Resveratrol is combined with Enoxaparin.
Epoprostenol The risk or severity of bleeding can be increased when Resveratrol is combined with Epoprostenol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Resveratrol is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Resveratrol is combined with Coumarin.
Ximelagatran The risk or severity of bleeding can be increased when Resveratrol is combined with Ximelagatran.
Desmoteplase The risk or severity of bleeding can be increased when Resveratrol is combined with Desmoteplase.
Defibrotide The risk or severity of bleeding can be increased when Resveratrol is combined with Defibrotide.
Ancrod The risk or severity of bleeding can be increased when Resveratrol is combined with Ancrod.
Beraprost The risk or severity of bleeding can be increased when Resveratrol is combined with Beraprost.
Prasugrel The risk or severity of bleeding can be increased when Resveratrol is combined with Prasugrel.
Sulodexide The risk or severity of bleeding can be increased when Resveratrol is combined with Sulodexide.
Semuloparin The risk or severity of bleeding can be increased when Resveratrol is combined with Semuloparin.
Idraparinux The risk or severity of bleeding can be increased when Resveratrol is combined with Idraparinux.
Cangrelor The risk or severity of bleeding can be increased when Resveratrol is combined with Cangrelor.
Astaxanthin The risk or severity of bleeding can be increased when Resveratrol is combined with Astaxanthin.
Otamixaban The risk or severity of bleeding can be increased when Resveratrol is combined with Otamixaban.
Amediplase The risk or severity of bleeding can be increased when Resveratrol is combined with Amediplase.
Danaparoid The risk or severity of bleeding can be increased when Resveratrol is combined with Danaparoid.
Dalteparin The risk or severity of bleeding can be increased when Resveratrol is combined with Dalteparin.
Tinzaparin The risk or severity of bleeding can be increased when Resveratrol is combined with Tinzaparin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Resveratrol is combined with Ethyl biscoumacetate.
Nadroparin The risk or severity of bleeding can be increased when Resveratrol is combined with Nadroparin.
Triflusal The risk or severity of bleeding can be increased when Resveratrol is combined with Triflusal.
Ticagrelor The risk or severity of bleeding can be increased when Resveratrol is combined with Ticagrelor.
Ditazole The risk or severity of bleeding can be increased when Resveratrol is combined with Ditazole.
Vorapaxar The risk or severity of bleeding can be increased when Resveratrol is combined with Vorapaxar.
Edoxaban The risk or severity of bleeding can be increased when Resveratrol is combined with Edoxaban.
Sodium citrate The risk or severity of bleeding can be increased when Resveratrol is combined with Sodium citrate.
Dextran The risk or severity of bleeding can be increased when Resveratrol is combined with Dextran.
Bemiparin The risk or severity of bleeding can be increased when Resveratrol is combined with Bemiparin.
Parnaparin The risk or severity of bleeding can be increased when Resveratrol is combined with Parnaparin.
Desirudin The risk or severity of bleeding can be increased when Resveratrol is combined with Desirudin.
Antithrombin Alfa The risk or severity of bleeding can be increased when Resveratrol is combined with Antithrombin Alfa.
Protein C The risk or severity of bleeding can be increased when Resveratrol is combined with Protein C.
Antithrombin III human The risk or severity of bleeding can be increased when Resveratrol is combined with Antithrombin III human.
Letaxaban The risk or severity of bleeding can be increased when Resveratrol is combined with Letaxaban.
Darexaban The risk or severity of bleeding can be increased when Resveratrol is combined with Darexaban.
Betrixaban The risk or severity of bleeding can be increased when Resveratrol is combined with Betrixaban.

Target Protein

NAD-dependent protein deacetylase sirtuin-1 SIRT1
Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2
Casein kinase II subunit alpha CSNK2A1
Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2
Polyunsaturated fatty acid lipoxygenase ALOX15 ALOX15
Polyunsaturated fatty acid 5-lipoxygenase ALOX5
Aryl hydrocarbon receptor AHR
Phosphatidylinositol 4-kinase type 2-beta PI4K2B
Integrin alpha-5 ITGA5
Integrin beta-3 ITGB3
Amyloid-beta precursor protein APP
Alpha-synuclein SNCA
Estrogen receptor ESR1
Melatonin receptor type 1A MTNR1A
Melatonin receptor type 1B MTNR1B
C-type lectin domain family 14 member A CLEC14A
Nuclear receptor subfamily 1 group I member 2 NR1I2
Nuclear receptor subfamily 1 group I member 3 NR1I3
Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1
Carbonyl reductase [NADPH] 1 CBR1
Peroxisome proliferator-activated receptor alpha PPARA
Peroxisome proliferator-activated receptor gamma PPARG
RAC-alpha serine/threonine-protein kinase AKT1
Far upstream element-binding protein 2 KHSRP
Tyrosine--tRNA ligase, cytoplasmic YARS1

Referensi & Sumber

Synthesis reference: Philippe Jeandet, Roger Bessis, Marielle Adrian, Jean-Claude Yvin, Jean-Marie Joubert, "Use of aluminium chloride as a resveratrol synthesis elicitor." U.S. Patent US6080701, issued August, 1991.
Artikel (PubMed)
  • PMID: 16401555
    Farina A, Ferranti C, Marra C: An improved synthesis of resveratrol. Nat Prod Res. 2006 Mar;20(3):247-52.
  • PMID: 7994864
    Renaud S, Ruf JC: The French paradox: vegetables or wine. Circulation. 1994 Dec;90(6):3118-9.
  • PMID: 11804508
    Wang Y, Catana F, Yang Y, Roderick R, van Breemen RB: An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine. J Agric Food Chem. 2002 Jan 30;50(3):431-5.
  • PMID: 13129286
    Lyons MM, Yu C, Toma RB, Cho SY, Reiboldt W, Lee J, van Breemen RB: Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem. 2003 Sep 24;51(20):5867-70.
  • PMID: 15333514
    Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK: High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004 Dec;32(12):1377-82. Epub 2004 Aug 27.
  • PMID: 17959154
    Csaki C, Keshishzadeh N, Fischer K, Shakibaei M: Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem Pharmacol. 2008 Feb 1;75(3):677-87. Epub 2007 Sep 18.
  • PMID: 10551373
    Docherty JJ, Fu MM, Stiffler BS, Limperos RJ, Pokabla CM, DeLucia AL: Resveratrol inhibition of herpes simplex virus replication. Antiviral Res. 1999 Oct;43(3):145-55.
  • PMID: 17054386
    N' soukpoe-Kossi CN, St-Louis C, Beauregard M, Subirade M, Carpentier R, Hotchandani S, Tajmir-Riahi HA: Resveratrol binding to human serum albumin. J Biomol Struct Dyn. 2006 Dec;24(3):277-83.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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