Fusidic acid

DB02703

small molecule approved investigational

Deskripsi

An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. It is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections.

Struktur Molekul 2D

Berat 516.7092
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 5 to 6 hours in adults.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.

Metabolisme

Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with food. Food reduces irritation.

Interaksi Obat

1118 Data
Glycochenodeoxycholic Acid Fusidic acid may decrease the excretion rate of Glycochenodeoxycholic Acid which could result in a higher serum level.
Glimepiride Fusidic acid may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Diethylstilbestrol Fusidic acid may decrease the excretion rate of Diethylstilbestrol which could result in a higher serum level.
Isradipine Fusidic acid may decrease the excretion rate of Isradipine which could result in a higher serum level.
Flucloxacillin Fusidic acid may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Indomethacin Fusidic acid may decrease the excretion rate of Indomethacin which could result in a higher serum level.
Rosiglitazone Fusidic acid may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Atropine Fusidic acid may decrease the excretion rate of Atropine which could result in a higher serum level.
Diclofenac Fusidic acid may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Losartan The metabolism of Losartan can be decreased when combined with Fusidic acid.
Fluorescein Fusidic acid may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Nitrofurantoin Fusidic acid may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Naproxen Fusidic acid may decrease the excretion rate of Naproxen which could result in a higher serum level.
Disulfiram Fusidic acid may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Cefaclor Fusidic acid may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Mifepristone Fusidic acid may decrease the excretion rate of Mifepristone which could result in a higher serum level.
Tinidazole Fusidic acid may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Repaglinide Fusidic acid may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Telmisartan Fusidic acid may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Ezetimibe Fusidic acid may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Dipyridamole Fusidic acid may decrease the excretion rate of Dipyridamole which could result in a higher serum level.
Sulfamethoxazole Fusidic acid may decrease the excretion rate of Sulfamethoxazole which could result in a higher serum level.
Fenofibrate Fusidic acid may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Nitrendipine Fusidic acid may decrease the excretion rate of Nitrendipine which could result in a higher serum level.
Glipizide Fusidic acid may decrease the excretion rate of Glipizide which could result in a higher serum level.
Sulfinpyrazone Fusidic acid may decrease the excretion rate of Sulfinpyrazone which could result in a higher serum level.
Ofloxacin Fusidic acid may decrease the excretion rate of Ofloxacin which could result in a higher serum level.
Taurocholic acid Fusidic acid may decrease the excretion rate of Taurocholic acid which could result in a higher serum level.
Prasterone sulfate Fusidic acid may decrease the excretion rate of Prasterone sulfate which could result in a higher serum level.
Indocyanine green acid form Fusidic acid may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level.
Benzbromarone Fusidic acid may decrease the excretion rate of Benzbromarone which could result in a higher serum level.
Pilsicainide Fusidic acid may decrease the excretion rate of Pilsicainide which could result in a higher serum level.
Dihydroergocristine Fusidic acid may decrease the excretion rate of Dihydroergocristine which could result in a higher serum level.
Glycyrrhizic acid Fusidic acid may decrease the excretion rate of Glycyrrhizic acid which could result in a higher serum level.
Loratadine Fusidic acid may decrease the excretion rate of Loratadine which could result in a higher serum level.
Budesonide Fusidic acid may decrease the excretion rate of Budesonide which could result in a higher serum level.
Felodipine Fusidic acid may decrease the excretion rate of Felodipine which could result in a higher serum level.
Belantamab mafodotin Fusidic acid may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Fusidic acid.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Fusidic acid.
Everolimus The metabolism of Everolimus can be decreased when combined with Fusidic acid.
Flibanserin The metabolism of Flibanserin can be decreased when combined with Fusidic acid.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Fusidic acid.
Ivabradine The metabolism of Ivabradine can be decreased when combined with Fusidic acid.
Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Fusidic acid.
Lurasidone The metabolism of Lurasidone can be decreased when combined with Fusidic acid.
Naloxegol The metabolism of Naloxegol can be decreased when combined with Fusidic acid.
Olaparib The metabolism of Olaparib can be decreased when combined with Fusidic acid.
Ranolazine The metabolism of Ranolazine can be decreased when combined with Fusidic acid.
Sonidegib The metabolism of Sonidegib can be decreased when combined with Fusidic acid.
Avanafil The metabolism of Avanafil can be decreased when combined with Fusidic acid.
Eplerenone The metabolism of Eplerenone can be decreased when combined with Fusidic acid.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Fusidic acid.
Colchicine The metabolism of Colchicine can be decreased when combined with Fusidic acid.
Fentanyl The metabolism of Fentanyl can be decreased when combined with Fusidic acid.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Fusidic acid.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Fusidic acid.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Fusidic acid.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Fusidic acid.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Fusidic acid.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Fusidic acid.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Fusidic acid.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Fusidic acid.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Fusidic acid.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Fusidic acid.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Fusidic acid.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Fusidic acid.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Fusidic acid.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Fusidic acid.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Fusidic acid.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Fusidic acid.
Desogestrel The metabolism of Fusidic acid can be increased when combined with Desogestrel.
Zidovudine The metabolism of Fusidic acid can be increased when combined with Zidovudine.
Lamotrigine The metabolism of Fusidic acid can be increased when combined with Lamotrigine.
Testosterone propionate The metabolism of Fusidic acid can be increased when combined with Testosterone propionate.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Fusidic acid.
Mirabegron The serum concentration of Fusidic acid can be increased when it is combined with Mirabegron.
Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Fusidic acid.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fusidic acid.
Pravastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Pravastatin.
Lovastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Lovastatin.
Cerivastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Cerivastatin.
Simvastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Simvastatin.
Atorvastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Atorvastatin.
Fluvastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Fluvastatin.
Rosuvastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Rosuvastatin.
Mevastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Mevastatin.
Pitavastatin The risk or severity of rhabdomyolysis can be increased when Fusidic acid is combined with Pitavastatin.
Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Fusidic acid.
Progesterone The metabolism of Progesterone can be decreased when combined with Fusidic acid.
Chlorpromazine The metabolism of Fusidic acid can be decreased when combined with Chlorpromazine.
Cimetidine The risk or severity of liver damage can be increased when Cimetidine is combined with Fusidic acid.
Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Fusidic acid.
Letermovir The excretion of Letermovir can be decreased when combined with Fusidic acid.
Fluvoxamine The metabolism of Fusidic acid can be decreased when combined with Fluvoxamine.
Atenolol The metabolism of Atenolol can be decreased when combined with Fusidic acid.
Imatinib The serum concentration of Fusidic acid can be increased when it is combined with Imatinib.
Nicardipine The metabolism of Fusidic acid can be decreased when combined with Nicardipine.
Nifedipine The metabolism of Nifedipine can be decreased when combined with Fusidic acid.
Erlotinib The metabolism of Erlotinib can be decreased when combined with Fusidic acid.

Target Protein

Elongation factor G fusA
Chloramphenicol acetyltransferase cat
Chloramphenicol acetyltransferase 3 cat3

Referensi & Sumber

Synthesis reference: Vanangamudi Subramaniam Sulur, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Haridas Sankar, Selvaraj Balkrishnan, " PROCESS TO MAKE FUSIDIC ACID CREAM." U.S. Patent US20110301138, issued December 08, 2011.

Contoh Produk & Brand

Produk: 14 • International brands: 3
Produk
  • Fucibet
    Cream • - • Topical • Canada • Approved
  • Fucidin
    Ointment • 20 mg/1g • Topical • US • OTC
  • Fucidin
    Ointment • 20 mg/1g • Topical • US • OTC
  • Fucidin
    Ointment • 20 mg/1g • Topical • US • OTC
  • Fucidin Cream 2%
    Cream • 2 % • Topical • Canada • Approved
  • Fucidin Film Coated Tab 250mg
    Tablet • 250 mg • Oral • Canada • Approved
  • Fucidin H
    Cream • - • Topical • Canada • Approved
  • Fucidin Intertulle 2%
    Dressing • 2 % • Topical • Canada • Approved
Menampilkan 8 dari 14 produk.
International Brands
  • Fucidine
  • Fudic
  • Taksta

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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